Armando Tripodi
Armando Tripodi
The complex coagulation defect secondary to chronic liver disease is considered responsible for the bleeding problems that often are associated with the disease. Accordingly, clinicians order laboratory tests to assess the risk of bleeding ...
M Senzolo,E Cholongitas,U Thalheimer et al.
M Senzolo et al.
Liver cirrhosis is characterized by impairment of primary and secondary hemostasis but it is not clear how this impairment is related to the bleeding problems seen in cirrhosis. This delicate hemostatic balance can be perturbed by numerous ...
Superimposed coagulopathic conditions in cirrhosis: infection and endogenous heparinoids, renal failure, and endothelial dysfunction [0.03%]
肝硬化叠加的凝血病理状况：感染和内源性肝素样物质、肾衰竭和血管内皮功能障碍
Jasper H Smalberg,Frank W G Leebeek
Jasper H Smalberg
In this article, the authors discuss three pathophysiologic mechanisms that influence the coagulation system in patients who have liver disease. First, bacterial infections may play an important role in the cause of variceal bleeding in pat...
Domenico Ferro,Andrea Celestini,Francesco Violi
Domenico Ferro
The incidence of hyperfibrinolysis in patients with cirrhosis is still debated. The reasons for this uncertainty probably lie in the lack of appropriate laboratory tests for its evaluation. There is a relative consensus, however, that hyper...
Greg G C Hugenholtz,Robert J Porte,Ton Lisman
Greg G C Hugenholtz
Patients who have liver disease commonly present with alterations in platelet number and function. Recent data have questioned the contribution of these changes to bleeding complications in these patients. Modern tests of platelet function ...
Dougald M Monroe,Maureane Hoffman
Dougald M Monroe
The coagulation "cascade" model accurately represents the mechanisms of the prothrombin time and activated partial thromboplastin time tests. However, these tests and the "cascade" model do not accurately reflect the risk of hemorrhage or t...
Coagulation and hemostasis in liver disease: controversies and advances. Preface [0.03%]
肝病的凝血与止血：争议和进展。序言
Stephen H Caldwell,Arun J Sanyal
Stephen H Caldwell
Don C Rockey
Don C Rockey
Chronic injury results in a wound healing response that eventually leads to fibrosis. The response is generalized, with features common among multiple organ systems. In the liver, various different types of injury lead to fibrogenesis, impl...
Roben G Gieling,Alastair D Burt,Derek A Mann
Roben G Gieling
The concept that liver fibrosis is a dynamic process with potential for regression as well as progression has emerged in parallel with clinical evidence for remodeling of fibrotic extracellular matrix in patients who can be effectively trea...
Massimo Pinzani,Francesco Vizzutti
Massimo Pinzani
In recent years, practicing hepatologists have directed their attention to the most relevant outcome of most chronic liver diseases (CLD), ie, the progressive substitution of the functioning hepatic parenchyma with fibrotic tissue. Signific...