Cholestatic Liver Disease Across the Life Span: A Primer for Clinicians [0.03%]
贯穿生命周期的胆汁郁积性肝病：临床医师指南
Aliya Gulamhusein,Gideon Hirschfield
Aliya Gulamhusein
Recurrence of Primary Biliary Cholangitis and Primary Sclerosing Cholangitis after Liver Transplantation: Current Evidence and Clinical Implications [0.03%]
肝移植后原发性胆汁性胆管炎和原发性硬化性胆管炎的复发：现有证据及临床意义
Yu Jun Wong,Guan Sen Kew,Aldo J Montano-Loza
Yu Jun Wong
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are progressive cholestatic autoimmune liver diseases, characterized by the destruction of intrahepatic and/or extrahepatic bile ducts, leading to cirrhosis and live...
Asim Abdulhamid,Gregory J Gores,Julie K Heimbach et al.
Asim Abdulhamid et al.
This clinical review details the current approach for the detection and management of perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis. It summarizes the contemporary understanding of epidemiology, risk factors, ...
Kareem Khalaf,Natalia Causada Calo
Kareem Khalaf
Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) is a steroid-responsive biliary manifestation of IgG4-related disease, commonly associated with type I autoimmune pancreatitis and can mimic primary SC or cholangiocarcinoma. Diagno...
"Overlap" Syndromes in Autoimmune Liver Disease: Definitions, Clinical Challenges and Future Directions [0.03%]
自身免疫性肝病中的重叠综合征：定义、临床挑战及未来方向
Roie Tzadok,Inbal Houri
Roie Tzadok
Autoimmune liver diseases, including autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis, are rare chronic conditions characterized by immune-mediated hepatobiliary injury. While traditionally viewed as dis...
Nasir Hussain,Palak J Trivedi
Nasir Hussain
Sclerosing cholangitis encompasses a spectrum of disorders, characterised by multi-level biliary stricturing. The prefix 'primary' refers to the commonest form, PSC. Although rare, incidence and prevalence are rising, which when coupled wit...
Primary Biliary Cholangitis [0.03%]
原发性胆汁性胆管炎
Francesca Bolis,Marco Carbone
Francesca Bolis
Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease characterized by persistent cholestasis and progressive fibrosis. Diagnosis relies on cholestatic biochemistry with AMA or PBC-specific antinuclear antibodi...
Shital Gandhi,Brianna Barsanti-Innes,Gisele Jolicoeur et al.
Shital Gandhi et al.
Intrahepatic cholestasis of pregnancy is the most common liver disorder induced by pregnancy. It is characterized by pruritus, with onset typically at the end of the second trimester. Etiology is likely related to effects of estrogen and pr...
Eliza Flanagan,Natassia Pinpin Tan
Eliza Flanagan
This article focuses on common genetic cholestatic liver syndromes, looking at genotype-phenotype correlations in conditions such as progressive familial intrahepatic cholestasis (PFIC), bile acid synthesis disorders and cholangiopathies. I...
Biliary Atresia: A Focus on the Patient Journey from Diagnosis to Transplant [0.03%]
胆道闭锁：从诊断到移植的患者旅程聚焦
Katie R Conover,Alyssa R Goldberg,Krupa R Mysore et al.
Katie R Conover et al.
Biliary atresia is a complex cholangiopathy of infancy characterized by extrahepatic biliary obstruction and progressive intrahepatic fibroinflammatory injury. It remains the leading indication for liver transplant in children without any d...