High-Throughput DNA-Encoded Libraries Affinity Selection Platform for Binder Identification with Solid Support Protein Immobilization [0.03%]
用于结合物识别的高通量DNA编码库亲和选择平台（固相蛋白固定化）
Ramón Rama-Garda,Eduardo Domínguez,María Isabel Loza et al.
Ramón Rama-Garda et al.
DNA-encoded libraries (DELs) have demonstrated to be one of the most powerful technologies within the ligand identification toolbox, widely used either in academia or biotech and pharma companies. DEL methodology utilizes affinity selection...
Feature Engineering-Assisted Drug Repurposing on Disease-Drug Transcriptome Profiles in Gastric Cancer [0.03%]
基于基因表达谱的特征工程辅助胃癌老药新用研究
Kevser Kübra Kırboğa,Mithun Rudrapal
Kevser Kübra Kırboğa
Gastric cancer is one of the most common and deadly types of cancer in the world. To develop new biomarkers and drugs to diagnose and treat this cancer, it is necessary to identify the differences between the transcriptome profiles of gastr...
Antidiabetic Evaluation of Kigelia pinnata Root Bark Extract in Streptozotocin-Induced Type-2 Diabetes Model of Rats [0.03%]
Kigelia pinnata根皮提取物的抗糖尿病评价及在链脲佐菌素诱导的II型糖尿病大鼠模型中的作用研究
Ravindra Kumar,Neeraj Kumar,Satyendra Kumar Rajput et al.
Ravindra Kumar et al.
Diabetes mellitus (DM) is the most common endocrine disorder characterized by increased blood glucose levels resulting from defective insulin secretion, resistance to insulin action, or both. DM is often associated with severe complications...
High-Throughput Methods for the Discovery of Small Molecule Modulators of Pancreatic Beta-Cell Function and Regeneration [0.03%]
高效筛选小分子调节胰岛β细胞功能与再生的药物发现方法学研究
Sean M McCarty,Martin C Clasby,Jonathan Z Sexton
Sean M McCarty
The progression of type II diabetes (T2D) is characterized by a complex and highly variable loss of beta-cell mass, resulting in impaired insulin secretion. Many T2D drug discovery efforts aimed at discovering molecules that can protect or ...
A Perspective on Various Facets of Nanoemulsions and its Commercial Utilities [0.03%]
纳米乳液的各种特性及其商业用途的视角
Isha Mishra,Raghav Mishra,Ashutosh Dubey et al.
Isha Mishra et al.
Nanotechnology is a captivating contemporary technology owing to its extensive range of potential applications. This study emphasizes nanomaterials, substances with a size
Exosomes: Key Players for Treatment of Cancer and Their Future Perspectives [0.03%]
外泌体：癌症治疗的关键参与者及其未来展望
Reena Gupta,Jitendra Gupta,Suchismita Roy
Reena Gupta
A Review on Molecular Docking As an Interpretative Tool for Molecular Targets in Disease Management [0.03%]
分子对接作为疾病管理中分子靶标解释工具的回顾
Divya Sahu,Lokendra Singh Rathor,Shradha Devi Dwivedi et al.
Divya Sahu et al.
One of the most often utilized methods for drug discovery is molecular docking. With docking, one may discover new therapeutically relevant molecules by targeting the molecule and predicting the target-ligand interactions as well as differe...
Potential of Nanocarrier-Associated Approaches for Better Therapeutic Intervention in the Management of Glioblastoma [0.03%]
纳米载药相关方法在胶质母细胞瘤治疗中应用的潜力
Vikram,Shobhit Kumar,Javed Ali et al.
Vikram et al.
Glioblastoma, commonly known as glioblastoma multiforme (GBM), is one of the deadliest and most invasive types of brain cancer. Two factors account for the majority of the treatment limitations for GBM. First, the presence of the blood-brai...
Nanoliposomes Embedded Nanocochleates for Codelivery of Artemether and Lumefantrine: An In Vitro and In Vivo Study [0.03%]
用于共输送蒿甲醚和隆脱因的纳米脂质体嵌入的纳米蜗牛体的体内体外研究
Dyandevi Mathure,Prashant Sonawane,Hemantkumar Ranpise et al.
Dyandevi Mathure et al.
Antimalarial drugs are being encapsulated in nanotechnology-based carriers because there are not enough new treatment options and people are becoming more resistant to the ones that are already available. This approach uses two or more bioc...
Quality by Design Assisted Development of Luliconazole Transethosomes in Gel for the Management of Candida albicans Infection [0.03%]
基于质量设计的 luliconazole 转移乙醇体凝胶在管理白色念珠菌感染中的应用开发
Gurmeet Singh,Raj Kumar Narang
Gurmeet Singh
The objective of this study was to develop and evaluate a novel vesicular formulation of luliconazole (LUL) for the management of Candida albicans infection through a topical route. LUL-loaded transethosomes (LUL-TE) were prepared by the fi...