Integrated In Vivo and In Silico Approaches for Targeting JAK2/STAT3/SOCS3: Repurposing Boeravinone B and Resveratrol as Chemopreventive Agents in Colon Cancer [0.03%]
集体内和计算方法针对JAK2 / STAT3 / SOCS3的靶向：将Boeravinone B和白藜芦醇重新定位为结直肠癌化学预防剂
Shabnoor Iqbal,Usman Khan
Shabnoor Iqbal
Colon cancer ranks among the most prevalent malignancies worldwide and contributes substantially to cancer-related mortality. This study employed an integrated approach to evaluate the chemopreventive effects of Boeravinone B (BB) and Resve...
Molecular Mechanisms and Optimization Strategies for the Impact of Antihypertensive, Lipid-Lowering, and Antidiabetic Drugs on Gut Microbiota [0.03%]
抗高血压、降血脂和抗糖尿病药物影响肠道微生物的分子机制及优化策略
Ningning Xie,Yahan Zhang
Ningning Xie
Patients often suffer from hypertension, hyperlipidemia, and diabetes, requiring long-term polypharmacy. These drugs may alter gut microbiota composition, leading to adverse effects, but the underlying mechanisms are unclear. We selected 23...
Identification of Broad-Spectrum Inhibitors Targeting Multiple Amyloidogenic Proteins Using Functional Group-Based Virtual Screening [0.03%]
基于功能团的虚拟筛选鉴定广谱抗淀粉样蛋白生成多靶点抑制剂
Jiajun Huang,Chaohong Da,Shengrui Zhai et al.
Jiajun Huang et al.
Amyloidosis comprises a spectrum of protein misfolding disorders characterized by the aggregation of diverse amyloidogenic proteins into cytotoxic fibrillar structures. Due to the conserved β-sheet-rich architecture of fibrils across vario...
Formulation, Characterization, and Biological Assessment of Embelin-Loaded Glycerosomes [0.03%]
恩比林载甘油体的制备、表征及生物评价
Monika Dhaka,Md Habban Akhter,Maha Alsunbul
Monika Dhaka
Despite embelin's (EB) promising biological activities including the hepatoprotective effect, its clinical use is constrained by inadequate solubility and low oral bioavailability, which restrict its therapeutic effectiveness. The current s...
Comprehensive Physicochemical Characterization and Release Kinetics of an Astaxanthin Nanoplex: Integrated In Silico and In Vitro Evaluation [0.03%]
虾青素纳米复合物的全面理化特征和释放动力学：集成计算与体外综合评价
Manish Arora,Chetna Hemrajani,Anshul Jamwal et al.
Manish Arora et al.
Astaxanthin (AST) is a potent xanthophyll carotenoid that is well known for its extraordinary therapeutic and antioxidant properties. However, its weak water solubility and low bioavailability limit its application in pharmaceuticals. The p...
Indolizine Compound Selection for HPV Anticancer Active Prediction Using CNN Classifier with ADME Descriptors [0.03%]
基于CNN分类器的ADME描述符选择用于HPV抗肿瘤活性预测的吲哚嗪类化合物筛选
Sangeeta Mahaur,Sukirti Upadhyay
Sangeeta Mahaur
Despite the significant progress made in developing different in silico methodology for structure activity research over the past few decades. The ability to predict correlation structure activity (CSA) from absorption distribution metaboli...
Ellagic Acid-Loaded Microsponges Impregnated Chitosan-Guar Gum Hydrogel for Wound Therapy: Investigation on Rheology, Antioxidant, and Antimicrobial Activities [0.03%]
负载elf酸的微海绵包埋壳聚糖- guar胶水凝胶的伤口治疗：流变学，抗氧化和抗菌活性的研究
Manjeet Dahiya,Anroop B Nair,Varsha Kadian et al.
Manjeet Dahiya et al.
The therapeutic efficacy of ellagic acid could be improved by developing suitable carrier system. The present research was to develop ellagic acid-loaded microsponges impregnated with chitosan-guar gum hydrogel and evaluate its potential as...
Yuhan Qu,Fuming Liu
Yuhan Qu
This study demonstrates through an integrated computational and experimental approach that classical calcium channel blockers (CCBs) from four distinct structural classes possess previously unrecognized Mu-opioid receptor (MOR) activation c...
Network Pharmacology Combined with Experimental Validation to Investigate the Mechanism of Huxinkang Tablets in Treating Atherosclerosis by Modulating Macrophages [0.03%]
基于网络药理学结合实验验证的护心康片调控巨噬细胞治疗动脉粥样硬化的机制研究
Zhengke Yu,Guobing Zhou,Kaili Wang et al.
Zhengke Yu et al.
Huxinkang tablets (HXKT) is the formula prescription of Traditional Chinese Medicine for treating atherosclerosis (AS), but its underlying mechanisms remain unclear. Network pharmacology and experimental verification were integrated to expl...
Computational Prediction and In Vitro Validation of Potential Molecular Targets Associated with Adverse Reactions of Antimicrobial Drugs in Neonates [0.03%]
抗菌药物不良反应的潜在作用靶点计算预测及体外验证研究
Xiaojuan He,Rui Jing,Na Wu et al.
Xiaojuan He et al.
Neonates are particularly susceptible to a range of adverse reactions when administered antimicrobial drugs, including allergic reactions, gastrointestinal discomfort, and hepatic or renal dysfunction. These adverse reactions can have signi...