Validation of an Reverse phase high performance liquid chromatography Method for In Vitro Quantification and Degradation Analysis of Naphthol AS-E Phosphate in Bulk Drugs and Nanoparticles [0.03%]
原料药和纳米颗粒中AS-E萘酚磷酸的体外量化及降解分析用反相高效液相色谱法的验证
Kangkan Sarma,Md Habban Akther,Maha Alsunbul et al.
Kangkan Sarma et al.
This study presents the first validated High-performance liquid chromatography (HPLC) technique for quantifying naphthol AS-E phosphate (NASEP) in bulk drugs and nanoparticle formulation. A C18 HPLC cartridge (250 × 4.6 mm, 5 µm particle ...
Ultrafast Detection of Environmental Pollutants and Pharmaceutical Residues Using a CuFe Nanozyme-Enhanced Sensing Platform [0.03%]
一种基于纳米酶增强型传感器平台的超快检测环境污染物及药物残留的方法
Dilpreet Singh
Dilpreet Singh
The aim of this study was to develop a novel CuFe nanozyme-enhanced sensing platform for the ultrafast detection of trace analytes, specifically targeting environmental pollutants and heavy metals. The objectives of the research included ev...
Precision Targeting in Gastric Cancer: AI-Driven Discovery of MET, ADORA2A, CDK5R1, and ADORA1 [0.03%]
人工智能驱动的胃癌精准治疗靶点发现：MET、ADORA2A、CDK5R1和ADORA1基因的功能研究
Tiantian Tuo,Mengchan Wang
Tiantian Tuo
In this study, we integrated computational and experimental approaches to identify novel therapeutic targets and candidate compounds for gastric cancer (GC). Through in silico analyses, including target prediction, pathway enrichment, and m...
Nanoengineering of Exosomal Surfaces for Precision Targeting and Payload Delivery at the Molecular Level [0.03%]
纳米工程化外泌体表面用于分子水平的精准靶向及负载递送
Dilpreet Singh,Satvir Singh,Nitin Tandon
Dilpreet Singh
Exosomes, nano-sized extracellular vesicles secreted by almost all cell types, have emerged as biologically compatible vehicles for targeted drug delivery, gene therapy, and molecular diagnostics. Their innate ability to traverse biological...
Advances in Capsaicin-Based Nanocarriers: Bridging Mechanistic Insights with Therapeutic Potential and Clinical Outcomes [0.03%]
基于辣椒素的纳米载体进展：从机制洞察到治疗潜力和临床结局
Kiran Patil,Meghanath B Shete,Tulshidas Patil et al.
Kiran Patil et al.
Capsaicin (CAP), a bioactive compound from chili peppers, possesses a wide range of therapeutic properties, including antiobesity, anticancer, anti-inflammatory, analgesic, and cardioprotective effects. However, its clinical application has...
Neuroprotective Potential of Saroglitazar Against Cerebral Ischemia/Reperfusion Injury in Sprague Dawley Rats: Targeting HMGB-1/NF-κB Pathway [0.03%]
靶向HMGB-1/NF-κB信号通路，沙罗glitazar对Wistar大鼠脑缺血再灌注损伤的神经保护作用研究
Prachi Mistry,Sanjiv Prajapati,Paridhi Vadher et al.
Prachi Mistry et al.
Stroke is an intricate oxidative and inflammatory response resulting from cerebral ischemia followed by reperfusion injury. The complex pathophysiology of stroke poses challenges for treatment. Peroxisome proliferated-activated receptor (PP...
Identification of Selective Small Molecule Modulators of mRNA Processing Using a Multiplexed QuantiGene High-Throughput Screening Platform [0.03%]
基于多重QuantiGene高通量筛选平台的特异性小分子剪接调控化合物的识别与验证
Sarah Sirin,Nirodhini S Siriwardana,Michael Wood et al.
Sarah Sirin et al.
High-throughput screening (HTS) approaches incorporating multiplexed, cell-based assays are increasingly common for identifying novel modulators of complex biological processes. To enable the discovery of small molecule modulators of mRNA p...
Reversed-Phase High-Performance Liquid Chromatography Assisted Simultaneous Estimation and Validation as per ICHQ2(R2) Guidelines: Application of Method in Quantification of Paclitaxel and Berberine in Liposomes-Based Delivery System [0.03%]
ICHQ2(R2)指导下的同时估算和验证辅助反相高效液相色谱法在基于脂质体递送系统中紫杉醇和小檗碱定量中的方法应用
Debanjan Mukherjee,Raj Kamal,Akshay Kumar Lunawat et al.
Debanjan Mukherjee et al.
Berberine (BER) is an antioxidant, anti-inflammatory, and antitumor agent, while paclitaxel (PTX) is a widely used synthetic chemotherapeutic agent for breast cancer. Several reports have suggested the use of a PTX and BER combination for t...
Hermann A M Mucke
Hermann A M Mucke
From the steady stream of drug repurposing patent applications published under the Patent Cooperation Treaty (PCT), we have selected fifteen documents that first became available during the first quarter of 2025. As in each installment, som...
Exploring the Therapeutic Potential of Paclitaxel, Naringenin, and Quercetin: Structural Insights, Mechanisms of Action, and Drug Development Perspectives [0.03%]
紫杉醇、柚皮素和芦丁的治疗潜力探索：结构见解、作用机制及药物研发前景分析
Komal,Lovekesh Singh
Komal
This review examines the drug-like, cancer-suppressing, and food-based properties of paclitaxel, naringenin, and quercetin while emphasizing their therapeutic pathways and molecular functions. The chemotherapeutic agent paclitaxel stabilize...