Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library [0.03%]
一种筛选NIH化合物库高通量的方法识别出的cdc25b双特异性磷酸酶抑制剂
Paul A Johnston,Caleb A Foster,Marni Brisson Tierno et al.
Paul A Johnston et al.
The University of Pittsburgh Molecular Library Screening Center (Pittsburgh, PA) conducted a screen with the National Institutes of Health compound library for inhibitors of in vitro cell division cycle 25 protein (Cdc25) B activity during ...
A fluorescence-based high-throughput screening assay for the identification of T-type calcium channel blockers [0.03%]
一种用于鉴定T型钙离子通道阻滞剂的高通量荧光筛选法
Francesco Belardetti,Elizabeth Tringham,Cyrus Eduljee et al.
Francesco Belardetti et al.
T-type voltage-gated Ca(2+) channels have been implicated in contributing to a broad variety of human disorders, including pain, epilepsy, sleep disturbances, cardiac arrhythmias, and certain types of cancer. However, potent and selective T...
A mechanistically relevant cytotoxicity assay based on the detection of cellular GFP [0.03%]
一种基于细胞GFP检测的具有机制意义的细胞毒性试验
Michael Halter,Jamie L Almeida,Alessandro Tona et al.
Michael Halter et al.
Cell-based assays for measuring ribosome inhibition by proteins such as the plant toxin ricin are important for characterizing decontamination strategies and developing detection technologies for field use. We report here an assay for ricin...
Cytotoxicity assays are essential in the field of research as they enable the examination of cellular responses to stimuli and shed light on complex mechanisms involved in multiple diseases and drug development. This review covers a range o...