Glycerosomes: Versatile Carriers for Multi-Route Drug Delivery Systems [0.03%]
甘油体：多功能载体，适用于多途径药物递送系统
Kunal Banode,Omkar Patharkar,Vaishnavi Jadhav et al.
Kunal Banode et al.
Glycerosomes signify a groundbreaking advancement in drug delivery technology. Comprising glycerol, phospholipids, and water, glycerosomes offer superior drug stability, penetration, entrapment efficiency, fluidity, and viscosity compared w...
Development and Characterization of Oral Efavirenz-Loaded Nanostructured Lipid Carriers and Their Optimization with Box-Behnken Design Approach for the Neurological Disorder [0.03%]
Box-Behnken设计方法优化的口服 efavirenz 载药脂质纳米载体的开发及表征用于神经紊乱疾病
Ali Sartaj,Bushra Nabi,Ashif Iqubal et al.
Ali Sartaj et al.
To enhance brain delivery of efavirenz (EFV), optimized nanostructured lipid carriers (NLCs) were developed using a melt-emulsification technique and probe sonication. Box-Behnken design was chosen to systematically analyze the effects of v...
Enhanced Anticancer Efficiency of Curcumin Co-Loaded Lawsone Solid Lipid Nanoparticles Against MCF-7 Breast Cancer Cell Lines: Optimization by Statistical JMP Software-Based Experimental Approach [0.03%]
基于统计JMP软件的实验方法优化共载姜黄素和律草素固体脂质纳米粒对MCF-7乳腺癌细胞系的抗癌效率增强作用
Shivarani Penugonda,Pranusha Beesappagari,Maddileti Repollu et al.
Shivarani Penugonda et al.
The present study highlighted enhancing the therapeutic effectiveness of curcumin (CUR) co-loaded lawsone (LS) through a solid lipid nanoparticles (SLNs)-based delivery system. The cetyl palmitate (CP), polyethylene glycol 400 (PEG), and pr...
Implementation of the Box-Behnken Design in the Development and Optimization of Methotrexate-Loaded Microsponges for Colon Cancer [0.03%]
博克-本肯设计在甲氨蝶呤载药微海绵的制备及优化用于结肠癌中的应用实施研究
Mahendra Prajapati,Ranjit K Harwansh,Mohammad Akhlaquer Rahman et al.
Mahendra Prajapati et al.
Methotrexate (MTX) is an effective anticancer agent with limited water solubility, resulting in lower absorption in the gastrointestinal tract when administered orally. The present aim of the study is to construct sustained-release formulat...
Protective Effects of Schizochytrium Microalgal Fatty Acids on Alcoholic Liver Disease: A Network Pharmacology and In Vivo Study [0.03%]
海洋微藻施氏丰年虫油脂肪酸防治酒精性肝病的网络药理学及动物实验研究
Cailin Luo,Li Tian,Yangmin Wen et al.
Cailin Luo et al.
This study aimed to elucidate the hepatoprotective mechanisms of microalgal fatty acids (MFA) from Schizochytrium against alcoholic liver disease (ALD) through network pharmacology and in vivo analysis. Network pharmacology and molecular do...
Gabriel Atampugbire,Eureka Emefa Ahadjie Adomako,Osbourne Quaye
Gabriel Atampugbire
Viral diseases remain a significant challenge for global health with rising fatalities each year. In vitro assays are crucial techniques that have been utilized by researchers in the quest to develop antiviral therapies. These assays mimic ...
In Silico Screening of Phytochemicals as Potential Inhibitors of the JAK/STATs Pathway in Psoriasis [0.03%]
基于计算的植物化学成分筛选作为银屑病中JAK/STAT通路潜在抑制剂的研究
Lokendra Singh Rathor,Divya Sahu,Manju Singh et al.
Lokendra Singh Rathor et al.
The skin is a dynamic tissue that consists of different layers such as stratum corneum, the site for keratinocyte development and maturation for the natural changeover of skin. In psoriasis, this natural development of keratinocytes gets di...
Optimization of Docetaxel-Zedoary Turmeric Oil Magnetic Solid Lipid Nanoparticle Preparation by Central Composite Design-Response Surface Methodology [0.03%]
响应面法优化多西他赛-温郁金挥发油磁性固脂纳米粒的制备条件研究
Yujiao Hou,Yuesheng Zhao,Jun Liu et al.
Yujiao Hou et al.
To optimize the formulation of docetaxel-zedoary oil magnetic solid lipid nanoparticles (DTX-ZTO-MSLN) using central composite design-response surface methodology. First, the formulation and preparation process of DTX-ZTO-MSLN were optimize...
Future Prospects and Regulatory Pathways for Invasome Technologies in Transdermal Drug Delivery [0.03%]
用于经皮药物递送的侵入体技术的未来前景及监管途径
Dinesh Kumar,Debayan Sil,Balak Das Kurmi et al.
Dinesh Kumar et al.
Skin is one of the largest organs in the human body. It acts as an outer protective cover and comprises the epidermis, dermis, and hypodermis. Liposomes are formed by phospholipids and have a vesicular character that improves the encapsulat...
Golden Therapeutic Approach to Combat Viral Diseases Using Gold Nanomaterials [0.03%]
利用金纳米材料治疗病毒性疾病的新方法研究进展
Jasmine,Neelam Singh,Dheeraj Nagpal et al.
Jasmine et al.
Gold nanoparticles (AuNPs), due to their unique properties and surface modification abilities, have become a promising carrier for a range of biomedical applications. AuNPs have intrinsic antiviral characteristics because of their capacity ...