Pharmacodynamic and Physicochemical Evaluation of Intranasal Zolmitriptan-Loaded Nanostructured Lipid Carriers: for Enhanced Antimigraine Potential [0.03%]
佐米曲普坦纳米结构脂质载体鼻用制剂的药效学和理化评价：增强的抗偏头痛潜力
Hrushikesh S Dhande,Jayshree B Taksande,Nishant B Awandekar et al.
Hrushikesh S Dhande et al.
Migraine is a debilitating neuromuscular disorder marked by severe, one-sided headaches. Triptans, such as Zolmitriptan (ZMP), act as serotonin receptor agonists and are commonly used in migraine treatment. However, ZMP, classified under Bi...
Development and Fabrication of Emodin-Loaded Patches Using Geraniol as a Penetration Enhancer for Transdermal Delivery [0.03%]
使用香叶醇作为透皮吸收促进剂的巴豆素药贴的开发与研制
Suhas Shivaji Siddheshwar,Sandhya Jadhav,Someshwar Dattatraya Mankar et al.
Suhas Shivaji Siddheshwar et al.
Diabetes management necessitates innovative approaches to enhance treatment efficacy and patient adherence. The study aimed to develop a transdermal patch loaded with emodin, hypothesized to provide a noninvasive treatment option that circu...
Development of Luteolin-Loaded Calcium Alginate and Gum Tragacanth Blend Microbeads for Oral Delivery: In Vitro Characterization, Antioxidant, Antimicrobial, and Anticancer Activity Against Colon Cancer Cell Line (HT-29) [0.03%]
口服递送黄酮醇类化合物芹菜素的壳聚糖/明胶微球的开发及其体外特性、抗氧化活性和抗结肠癌活性的研究
Ameeduzzafar Zafar,Omar Awad Alsaidan,Md Ali Mujtaba et al.
Ameeduzzafar Zafar et al.
The utilization of herbal bioactive compounds for health maintenance is now increasing the interest of consumers because it has therapeutic benefits. Luteolin (LLN) is a natural bioactive compound and is found in various plant sources. It h...
Deep Learning Accelerates the Development of Antimicrobial Peptides Comprising 15 Amino Acids [0.03%]
深度学习加速了由15个氨基酸组成的抗菌肽的开发进程
Yuchen Hu,Junchao Zhou,Yuhang Gao et al.
Yuchen Hu et al.
The emergence of multidrug-resistant bacteria has led to an urgent need for novel antimicrobial agents. Antimicrobial peptides (AMPs) exhibit broad-spectrum and highly effective antibacterial activity and are less prone to resistance, makin...
Pharmacological Evaluation of Aescin for Neuroprotection in Intracerebroventricular Streptozotocin Model of Alzheimer's Disease in Experimental Rats [0.03%]
番木鳖素在实验大鼠脑室内链佐星阿尔茨海默病模型中神经营养药理学评价
Shaveta Bhardwaj,Anu Jindal,Shamsher Singh et al.
Shaveta Bhardwaj et al.
Alzheimer's disease (AD) is a neurological disorder that results in the loss of memory and cognitive functions linked to redox disbalance, neuroinflammation, neurotransmitters changes, and the accumulation of amyloid-beta (1-42) plaques in ...
Next-Gen Cancer Treatment: Nanotechnology-Driven siRNA Delivery Solutions [0.03%]
下一代癌症治疗：纳米技术驱动的siRNA传递方案
Harshita,Vancha Harish,Sakshi Lad Upendra et al.
Harshita et al.
RNA interference through small interfering RNA (siRNA) has shown great promise as a potential cancer treatment strategy in recent years. However, the delivery of siRNA to target cancer cells efficiently remains a significant challenge. This...
Mini Review on the Lyophilization: A Basic Requirement for Formulation Development and Stability Modifier [0.03%]
冷冻干燥微型综述：配方开发及稳定化因素的基本要求
Sachin Joshi,Priya Jindal,Shreastha Gautam et al.
Sachin Joshi et al.
Freeze-drying is popular for producing pharmaceutical formulations with structurally complicated active components and drug delivery system carriers. It is the process of eliminating water from ice crystals through the sublimation mechanism...
Investigating the Role of Buzhong Yiqi Decoction on Neurogenic Bladder with Network Pharmacology, Molecular Docking, and In Vitro Assays [0.03%]
补中益气汤治疗神经源性膀胱的作用机制的网络药理学，分子对接及体外研究探究
Yixin Bao,Chun Sun
Yixin Bao
Buzhong Yiqi decoction (BZYQD) is a traditional Chinese medicine prescription for treating neurogenic bladder (NB). However, the underlying pharmacological mechanism remains unclear. This study aims to clarify the related molecular mechanis...