Identification of Selective Small Molecule Modulators of mRNA Processing Using a Multiplexed QuantiGene High-Throughput Screening Platform [0.03%]
基于多重QuantiGene高通量筛选平台的特异性小分子剪接调控化合物的识别与验证
Sarah Sirin,Nirodhini S Siriwardana,Michael Wood et al.
Sarah Sirin et al.
High-throughput screening (HTS) approaches incorporating multiplexed, cell-based assays are increasingly common for identifying novel modulators of complex biological processes. To enable the discovery of small molecule modulators of mRNA p...
Reversed-Phase High-Performance Liquid Chromatography Assisted Simultaneous Estimation and Validation as per ICHQ2(R2) Guidelines: Application of Method in Quantification of Paclitaxel and Berberine in Liposomes-Based Delivery System [0.03%]
ICHQ2(R2)指导下的同时估算和验证辅助反相高效液相色谱法在基于脂质体递送系统中紫杉醇和小檗碱定量中的方法应用
Debanjan Mukherjee,Raj Kamal,Akshay Kumar Lunawat et al.
Debanjan Mukherjee et al.
Berberine (BER) is an antioxidant, anti-inflammatory, and antitumor agent, while paclitaxel (PTX) is a widely used synthetic chemotherapeutic agent for breast cancer. Several reports have suggested the use of a PTX and BER combination for t...
Hermann A M Mucke
Hermann A M Mucke
From the steady stream of drug repurposing patent applications published under the Patent Cooperation Treaty (PCT), we have selected fifteen documents that first became available during the first quarter of 2025. As in each installment, som...
Exploring the Therapeutic Potential of Paclitaxel, Naringenin, and Quercetin: Structural Insights, Mechanisms of Action, and Drug Development Perspectives [0.03%]
紫杉醇、柚皮素和芦丁的治疗潜力探索：结构见解、作用机制及药物研发前景分析
Komal,Lovekesh Singh
Komal
This review examines the drug-like, cancer-suppressing, and food-based properties of paclitaxel, naringenin, and quercetin while emphasizing their therapeutic pathways and molecular functions. The chemotherapeutic agent paclitaxel stabilize...
Hermann A M Mucke
Hermann A M Mucke
Here, we briefly discuss 17 PCT patent applications related to drug repurposing that were published during the final quarter of 2024. As always, we have chosen the documents based on significance only, which gave us a wide range of applican...
Development and Evaluation of Prednisolone Acetate-Loaded Nanostructured Lipid Carriers Integrated into pH-Triggered In Situ Gels for Ocular Drug Delivery [0.03%]
开发和评估用于眼部药物递送的pH触发型原位凝胶化的醋酸氢化可的松纳米结构脂质载体体系
Sheetal Devi,Vipin Saini,Navneet Mehan et al.
Sheetal Devi et al.
This study aimed to enhance the therapeutic efficacy of prednisolone by developing a nanostructured lipid carrier (NLC) system for topical ocular administration and addressing the limitations of current topical therapy. Drug-loaded NLCs (pr...
Neuroprotective Potential of Saroglitazar Against Cerebral Ischemia/Reperfusion Injury in Sprague-Dawley Rats: Targeting HMGB-1/NF-κB Pathway [0.03%]
靶向HMGB-1/NF-κB信号通路，沙索立扎他对抗Sprague-Dawley大鼠脑缺血再灌注损伤的神经保护作用研究
Prachi Mistry,Sanjiv Prajapati,Paridhi Vadher et al.
Prachi Mistry et al.
Stroke is an intricate oxidative and inflammatory response resulting from cerebral ischemia followed by reperfusion injury. Complex pathophysiology of stroke poses challenges for treatment. Peroxisome proliferator-activated receptor (PPAR) ...
Identification of Potential Molecular Targets of Doxorubicin for Application in Skin Cancer: A Network Pharmacology and Molecular Docking Perspective [0.03%]
从网络药理学和分子对接角度鉴定多柔比星治疗皮肤癌的潜在分子靶点
Sonali Karhana,Sanjula Baboota,Mohd Ashif Khan et al.
Sonali Karhana et al.
The primary objective was to find the pharmacological targets of doxorubicin and their mechanisms of action, with a dual focus on their therapeutic relevance in skin cancer treatment and their potential involvement in resistance to doxorubi...
Targeted Drug Delivery with Nanosponges and Nanocrystals: Innovations, Formulation Strategies, and Applications [0.03%]
靶向药物递送中的纳米海绵和纳米晶：创新、制剂策略及应用
Preeti Aneja,Rajender Guleria,Dev Prakash Dahiya
Preeti Aneja
The neoteric advancement in nanotechnology accompanied the development of targeted drug delivery system. The utmost muddle facing the investigators is targeted drug delivery to specific sites. The unfolding of a new nanoparticle carrier cal...
Modulation of Anti-Inflammatory Activity via Diclofenac Sodium-Based Nanostructured-Lipid Carriers: Physical Characterization and In Vivo Assessment [0.03%]
依托芬那钠纳米脂质载体的抗炎作用调节：物理特征和体内评估
Alok Pratap Singh,Dinesh Puri,Iti Chauhan et al.
Alok Pratap Singh et al.
Diclofenac sodium (DS) is categorized under the nonsteroidal anti-inflammatory class of drugs that also belongs to biopharmaceutical classification system (BCS) class II. It has limited dissolution parameters which also resist the total bio...