Decoding Cholesterol Metabolic Regulation by Naotai Formula in Stroke Management: An Integrated Network Pharmacology and Mendelian Randomization Approach [0.03%]
基于网络药理学和孟德尔随机化方法的通腑调脂颗粒解密脑血管病胆固醇代谢调控机制研究
Haiwei Jiang,Chang Gao,Dan Wang et al.
Haiwei Jiang et al.
Naotai formula (NTF) is clinically used for stroke treatment, yet its molecular mechanisms involving vascular and metabolic regulation remain unclear. This study combines network pharmacology (NP) and Mendelian randomization to explore NTF'...
Building a State-of-the-Art Automation Platform to Support High-Throughput 96-Well Caco-2 Permeability Assay [0.03%]
建立自动化平台支持高通量96孔Caco-2渗透试验
Xianmei Cai,Gregory Barker,Shivani Patel et al.
Xianmei Cai et al.
Automation plays a crucial role in enhancing efficiency and increasing capacity for in vitro absorption, distribution, metabolism, and excretion profiling in early drug discovery. Building an automation platform requires a careful balance o...
Revolutionizing Rheumatoid Arthritis Management: Glucocorticoid-Loaded, Folic Acid-Conjugated Piper nigrum-Based Zinc-Oxide Nanoparticles [0.03%]
Revolutionary Treatment for Rheumatoid Arthritis: Glucocorticoid-Loaded, Folic Acid-Conjugated Black Pepper-Based Zinc Oxide Nanoparticles
Shradha Devi Dwivedi,Deependra Singh,Manju Rawat Singh
Shradha Devi Dwivedi
Rheumatoid arthritis (RA) is a chronic inflammatory disease whose exact etiology is yet unidentified. Dexamethasone sodium phosphate (DSP) is an established anti-inflammatory agent, but its application is limited due to its dose-dependent t...
Corrigendum to: "Identification of Potential Molecular Targets of Doxorubicin for Application in Skin Cancer: A Network Pharmacology and Molecular Docking Perspective" [0.03%]
“基于网络药理学和分子对接视角的多柔比星在皮肤癌潜在作用靶点研究”的勘误通知
Published Erratum
Assay and drug development technologies. 2025 Oct;23(7):382. DOI:10.1177/1540658X251380551 2025
Validation of an Reverse phase high performance liquid chromatography Method for In Vitro Quantification and Degradation Analysis of Naphthol AS-E Phosphate in Bulk Drugs and Nanoparticles [0.03%]
原料药和纳米颗粒中AS-E萘酚磷酸的体外量化及降解分析用反相高效液相色谱法的验证
Kangkan Sarma,Md Habban Akther,Maha Alsunbul et al.
Kangkan Sarma et al.
This study presents the first validated High-performance liquid chromatography (HPLC) technique for quantifying naphthol AS-E phosphate (NASEP) in bulk drugs and nanoparticle formulation. A C18 HPLC cartridge (250 × 4.6 mm, 5 µm particle ...
Ultrafast Detection of Environmental Pollutants and Pharmaceutical Residues Using a CuFe Nanozyme-Enhanced Sensing Platform [0.03%]
一种基于纳米酶增强型传感器平台的超快检测环境污染物及药物残留的方法
Dilpreet Singh
Dilpreet Singh
The aim of this study was to develop a novel CuFe nanozyme-enhanced sensing platform for the ultrafast detection of trace analytes, specifically targeting environmental pollutants and heavy metals. The objectives of the research included ev...
Precision Targeting in Gastric Cancer: AI-Driven Discovery of MET, ADORA2A, CDK5R1, and ADORA1 [0.03%]
人工智能驱动的胃癌精准治疗靶点发现：MET、ADORA2A、CDK5R1和ADORA1基因的功能研究
Tiantian Tuo,Mengchan Wang
Tiantian Tuo
In this study, we integrated computational and experimental approaches to identify novel therapeutic targets and candidate compounds for gastric cancer (GC). Through in silico analyses, including target prediction, pathway enrichment, and m...
Nanoengineering of Exosomal Surfaces for Precision Targeting and Payload Delivery at the Molecular Level [0.03%]
纳米工程化外泌体表面用于分子水平的精准靶向及负载递送
Dilpreet Singh,Satvir Singh,Nitin Tandon
Dilpreet Singh
Exosomes, nano-sized extracellular vesicles secreted by almost all cell types, have emerged as biologically compatible vehicles for targeted drug delivery, gene therapy, and molecular diagnostics. Their innate ability to traverse biological...
Advances in Capsaicin-Based Nanocarriers: Bridging Mechanistic Insights with Therapeutic Potential and Clinical Outcomes [0.03%]
基于辣椒素的纳米载体进展：从机制洞察到治疗潜力和临床结局
Kiran Patil,Meghanath B Shete,Tulshidas Patil et al.
Kiran Patil et al.
Capsaicin (CAP), a bioactive compound from chili peppers, possesses a wide range of therapeutic properties, including antiobesity, anticancer, anti-inflammatory, analgesic, and cardioprotective effects. However, its clinical application has...
Neuroprotective Potential of Saroglitazar Against Cerebral Ischemia/Reperfusion Injury in Sprague Dawley Rats: Targeting HMGB-1/NF-κB Pathway [0.03%]
靶向HMGB-1/NF-κB信号通路，沙罗glitazar对Wistar大鼠脑缺血再灌注损伤的神经保护作用研究
Prachi Mistry,Sanjiv Prajapati,Paridhi Vadher et al.
Prachi Mistry et al.
Stroke is an intricate oxidative and inflammatory response resulting from cerebral ischemia followed by reperfusion injury. The complex pathophysiology of stroke poses challenges for treatment. Peroxisome proliferated-activated receptor (PP...