Deep Learning Accelerates the Development of Antimicrobial Peptides Comprising 15 Amino Acids [0.03%]
深度学习加速了由15个氨基酸组成的抗菌肽的开发进程
Yuchen Hu,Junchao Zhou,Yuhang Gao et al.
Yuchen Hu et al.
The emergence of multidrug-resistant bacteria has led to an urgent need for novel antimicrobial agents. Antimicrobial peptides (AMPs) exhibit broad-spectrum and highly effective antibacterial activity and are less prone to resistance, makin...
Pharmacological Evaluation of Aescin for Neuroprotection in Intracerebroventricular Streptozotocin Model of Alzheimer's Disease in Experimental Rats [0.03%]
番木鳖素在实验大鼠脑室内链佐星阿尔茨海默病模型中神经营养药理学评价
Shaveta Bhardwaj,Anu Jindal,Shamsher Singh et al.
Shaveta Bhardwaj et al.
Alzheimer's disease (AD) is a neurological disorder that results in the loss of memory and cognitive functions linked to redox disbalance, neuroinflammation, neurotransmitters changes, and the accumulation of amyloid-beta (1-42) plaques in ...
Next-Gen Cancer Treatment: Nanotechnology-Driven siRNA Delivery Solutions [0.03%]
下一代癌症治疗：纳米技术驱动的siRNA传递方案
Harshita,Vancha Harish,Sakshi Lad Upendra et al.
Harshita et al.
RNA interference through small interfering RNA (siRNA) has shown great promise as a potential cancer treatment strategy in recent years. However, the delivery of siRNA to target cancer cells efficiently remains a significant challenge. This...
Mini Review on the Lyophilization: A Basic Requirement for Formulation Development and Stability Modifier [0.03%]
冷冻干燥微型综述：配方开发及稳定化因素的基本要求
Sachin Joshi,Priya Jindal,Shreastha Gautam et al.
Sachin Joshi et al.
Freeze-drying is popular for producing pharmaceutical formulations with structurally complicated active components and drug delivery system carriers. It is the process of eliminating water from ice crystals through the sublimation mechanism...
Investigating the Role of Buzhong Yiqi Decoction on Neurogenic Bladder with Network Pharmacology, Molecular Docking, and In Vitro Assays [0.03%]
补中益气汤治疗神经源性膀胱的作用机制的网络药理学，分子对接及体外研究探究
Yixin Bao,Chun Sun
Yixin Bao
Buzhong Yiqi decoction (BZYQD) is a traditional Chinese medicine prescription for treating neurogenic bladder (NB). However, the underlying pharmacological mechanism remains unclear. This study aims to clarify the related molecular mechanis...
Glycerosomes: Versatile Carriers for Multi-Route Drug Delivery Systems [0.03%]
甘油体：多功能载体，适用于多途径药物递送系统
Kunal Banode,Omkar Patharkar,Vaishnavi Jadhav et al.
Kunal Banode et al.
Glycerosomes signify a groundbreaking advancement in drug delivery technology. Comprising glycerol, phospholipids, and water, glycerosomes offer superior drug stability, penetration, entrapment efficiency, fluidity, and viscosity compared w...
Development and Characterization of Oral Efavirenz-Loaded Nanostructured Lipid Carriers and Their Optimization with Box-Behnken Design Approach for the Neurological Disorder [0.03%]
Box-Behnken设计方法优化的口服 efavirenz 载药脂质纳米载体的开发及表征用于神经紊乱疾病
Ali Sartaj,Bushra Nabi,Ashif Iqubal et al.
Ali Sartaj et al.
To enhance brain delivery of efavirenz (EFV), optimized nanostructured lipid carriers (NLCs) were developed using a melt-emulsification technique and probe sonication. Box-Behnken design was chosen to systematically analyze the effects of v...
Enhanced Anticancer Efficiency of Curcumin Co-Loaded Lawsone Solid Lipid Nanoparticles Against MCF-7 Breast Cancer Cell Lines: Optimization by Statistical JMP Software-Based Experimental Approach [0.03%]
基于统计JMP软件的实验方法优化共载姜黄素和律草素固体脂质纳米粒对MCF-7乳腺癌细胞系的抗癌效率增强作用
Shivarani Penugonda,Pranusha Beesappagari,Maddileti Repollu et al.
Shivarani Penugonda et al.
The present study highlighted enhancing the therapeutic effectiveness of curcumin (CUR) co-loaded lawsone (LS) through a solid lipid nanoparticles (SLNs)-based delivery system. The cetyl palmitate (CP), polyethylene glycol 400 (PEG), and pr...
Implementation of the Box-Behnken Design in the Development and Optimization of Methotrexate-Loaded Microsponges for Colon Cancer [0.03%]
博克-本肯设计在甲氨蝶呤载药微海绵的制备及优化用于结肠癌中的应用实施研究
Mahendra Prajapati,Ranjit K Harwansh,Mohammad Akhlaquer Rahman et al.
Mahendra Prajapati et al.
Methotrexate (MTX) is an effective anticancer agent with limited water solubility, resulting in lower absorption in the gastrointestinal tract when administered orally. The present aim of the study is to construct sustained-release formulat...