Terpenes Encapsulated Polycaprolactone Nanoparticles for Topical Delivery of Hydrocortisone: In Vitro Study and In Vivo Appraisal [0.03%]
β-环糊精包合的聚己内酯载阿魏酸松属素纳osomes体外研究及兔眼角膜超微结构观察
Khaled Shalaby,Mohammed Elmowafy,Mohammed H Elkomy et al.
Khaled Shalaby et al.
This work aimed to develop and assess terpene encapsulated polycaprolactone (PCL) nanoparticles for topical delivery of hydrocortisone (HC). Formulations were designed to investigate the effect of terpene/PCL ratio and concentration of surf...
Spatiotemporal Nanocarriers for Circadian-Aligned Drug Delivery: Advances, Challenges, and Future Directions [0.03%]
时空纳米载体实现昼夜节律同步的药物递送：进展、挑战与未来方向
Dilpreet Singh,Akshay Thakur
Dilpreet Singh
Circadian rhythms orchestrate a wide array of physiological processes that critically influence drug absorption, distribution, metabolism, and excretion. Misalignment between drug administration and biological timing can compromise therapeu...
Tongnao Decoction Exerts a Treatment Effect on Ischemic Stroke by IL-6/PI3K/Akt/GSK-3β Pathway: Based on the Network Pharmacology and Molecular Docking [0.03%]
通窍活血汤通过IL-6/PI3K/AKT/GSK-3β信号途径对急性缺血性脑卒中的网络药理学及分子对接研究
Jiale Gan,Yujun Cong,Lulu Li et al.
Jiale Gan et al.
Ischemic stroke (IS) is an important disease leading to high disability and mortality, and the current clinical treatment is limited. Tongnao Decoction (TND) is a traditional Chinese herbal formula for treating IS, but its pharmacological m...
Targeting Quorum Sensing LsrR Protein in E. coli: A Computational Approach to Screen the Plant Bioactive Compounds as Inhibitors of Biofilm Formation in Urinary Tract Infections [0.03%]
针对大肠杆菌群体感应LsrR蛋白的靶标：筛选植物活性成分抑制尿路感染生物被膜形成的一个计算方法
Sitrarasu Vijaya Prabhu,Shreya Suman,Alagu Chellapandi et al.
Sitrarasu Vijaya Prabhu et al.
Antimicrobial resistance (AMR) in Escherichia coli, driven by biofilm formation and quorum sensing (QS), presents a significant challenge in combating infections, particularly urinary tract infections. This study explored the potential of p...
Formulation and Optimization of Chitosan-Based Flurbiprofen Nanoparticles for Ocular Delivery: A Design of Experiments Approach [0.03%]
基于壳聚糖的氟比洛芬纳米颗粒的配方和优化：一种实验设计方法用于眼部给药
Emine Dilek Özyılmaz
Emine Dilek Özyılmaz
This study aimed to design and develop flurbiprofen-loaded chitosan nanoparticles for ophthalmic drug delivery, with the objectives of enhancing formulation stability, sustaining drug release, and improving patient comfort. This study intro...
A Nasal Hydrogel Combining Metformin and Curcumin for Potential Nose-to-Brain Therapy in Neurodegenerative Disorders [0.03%]
一种结合二甲双胍和姜黄素的鼻用凝胶剂，用于神经退行性疾病的鼻脑递送治疗
Emine Dilek Özyılmaz
Emine Dilek Özyılmaz
Neurodegenerative disorders such as Alzheimer's and Parkinson's disease remain a significant therapeutic challenge due to the restrictive nature of the blood-brain barrier (BBB) and the limited efficacy of current pharmacological treatments...
Neprilysin Inhibitor and Angiotensin Receptor Blocker Attenuate Ischemic Brain Injury: Unveiling the Kinin-Mediated Pathway [0.03%]
neutral inhibitor和angiotensin受体阻滞剂通过缓激肽介导的通路减轻缺血性脑损伤
Geetika Mehta,Monika Sachdeva,Abul Kalam Najmi
Geetika Mehta
Kinin peptides play a key role in regulating blood vessel tone, renal function, and protection against ischemia-reperfusion injury. Neprilysin is one of the primary enzymes responsible for degrading several vasoactive peptides including bra...
Formulation Design, Optimization, and In Vitro Evaluation of Palbociclib-Loaded Polymeric Nanoparticles [0.03%]
帕博西尼载药聚合物纳米粒的处方设计、优化及体外评价研究
Nurjamal Hoque,Ananta Choudhury
Nurjamal Hoque
Palbociclib (PLB), an advanced breast cancer drug, shows limited success in clinical scenarios due to toxicity and resistant antitumor activities. The article aimed at preparing folic acid-modified chitosan-based polymeric nanoparticles (PN...
Jacob L Bouchard,Pedro de Andrade Horn,Yu Nishio et al.
Jacob L Bouchard et al.
The inward-rectifier potassium channel (Kir) 2.x family is an important family of ion channels in the context of human health. These potassium channels are involved in processes such as cardiac action potential, formation of skeletal muscle...
Kevin W-H Lo
Kevin W-H Lo