Development and Characterization of Novel Chitosan-Coated Curcumin Nanophytosomes for Treating Drug-Resistant Malaria [0.03%]
新型壳聚糖包裹的纳米层析体药物用于治疗抗药性疟疾的发展与特征分析
Bhargav Eranti,Padmanabha Reddy Yiragamreddy,Koteshwara Kunnatur Balasundara
Bhargav Eranti
This study aimed at enhancing the efficacy of curcumin (CR) by formulating and coating it with chitosan. In silico molecular docking studies revealed that CR exhibited almost similar and low binding energies when compared to artemisinin, in...
Optimization of Lurasidone HCl-Loaded PLGA Nanoparticles for Intramuscular Delivery: Enhanced Bioavailability, Reduced Dosing Frequency, Pharmacokinetics, and Therapeutic Outcomes [0.03%]
用于肌肉注射的卢拉西酮盐酸盐加载PLGA纳米颗粒的优化：提高生物利用度，减少给药频率，药代动力学及治疗结果
Nikita Macwan,Hemil S Patel,Rakesh K Sharma et al.
Nikita Macwan et al.
This study aimed to develop a nanoparticle drug delivery system using poly (lactic-co-glycolic acid) (PLGA) for enhancing the therapeutic efficacy of lurasidone hydrochloride (LH) in treatment of schizophrenia through intramuscular injectio...
Development and Validation of Reverse-Phase High-Performance Liquid Chromatography Method for Simultaneous Estimation of Doxorubicin and Clotrimazole [0.03%]
反相高效液相色谱法同时检测多柔比星和克霉唑的开发与验证
Priyanka Sharma,Bhupinder Kapoor,Md Sadique Hussain et al.
Priyanka Sharma et al.
A reverse-phase high-performance liquid chromatographic (RP-HPLC) method was developed to analyze the simultaneous estimation of doxorubicin and clotrimazole. The method was achieved by Nucleodur C18 column with dimension 250 × 4.6 mm (5 ...
Implementation of Quality by Design Approaches for Development and Validation of Reverse-Phase High-Performance Liquid Chromatography Assay Method for Determination of Glycyrrhizin in Nanoformulation [0.03%]
质量-by-设计方法在反相高效液相色谱法测定纳米制剂中甘草酸的开发和验证中的应用
Jitu Halder,Ivy Saha,Tushar Kanti Rajwar et al.
Jitu Halder et al.
Glycyrrhizin (GL) is the principal constituent of Glycyrrhiza glabra, having antiallergic, anticancer, anti-inflammatory, and antimicrobial action. The reverse-phase high-performance liquid chromatography (RP-HPLC) analytical method was use...
Liver-Targeting Composite Nanocarrier Delivery System Based on Chitosan Nanoparticles and Phospholipid Complexes [0.03%]
基于壳聚糖纳米粒和脂质复合物的肝靶向复合纳米载体递送系统
Fanming Kong,Jingmeng Sun,Yue Hu et al.
Fanming Kong et al.
Liver fibrosis is mainly caused by excessive accumulation of extracellular matrix and structural changes in the liver, ultimately leading to cirrhosis if left untreated. Reducing hyaluronan synthesis by inhibiting hyaluronic acid deposition...
α-Tocopherol Polyethylene Glycol 1000 Succinate-Based Cationic Liposome for the Intracellular Delivery of Doxorubicin in MDA-MB-231 Triple-Negative Breast Cancer Cell Line [0.03%]
α-生育酚聚乙二醇1000琥珀酸酯基阳离子脂质体在MDA-MB-231三阴性乳腺癌细胞系中递送多柔比星的体内细胞传递研究
Pallavi Sandal,Preeti Patel,Dilpreet Singh et al.
Pallavi Sandal et al.
Present research work reports the development of doxorubicin (DOX) loaded α-tocopherol polyethylene glycol 1000 succinate (TPGS)-coated cationic liposomes. The developed formulation was evaluated for its anticancer potential and intracellu...
A Short Appraisal of Biomimetic Hydrogels to Improve Penetration of Poorly Permeable Drugs [0.03%]
用于提高难渗透药物渗透的仿生水凝胶的研究进展简述
Dilpreet Singh,Sahil Arora,Vimal Arora
Dilpreet Singh
Effective drug delivery to target sites is critical for achieving desired therapeutic outcomes. However, the poor permeability of certain drugs poses significant challenges in achieving adequate drug concentrations at the desired locations....
Letter to the Editor: Repurposing Tafenoquine as a Potential Inhibitor Against Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease via a Fluorescence Polarization Assay [0.03%]
写给编辑室：使用荧光偏振测定法将tafenoquine重定位为潜在的严重急性呼吸系统综合症冠状病毒2主要蛋白酶抑制剂
Rui Zhang,Haohao Yan,Gangan Yan et al.
Rui Zhang et al.
Formulation and Characterization of Nanoparticulate Drug Carrier System for Lacidipine [0.03%]
拉西地平纳米药物载体系统的设计与评价
Ashveta Anant Dessai,Mrunali Navin Kantak,Cleona Elizabeth Mary DCruz et al.
Ashveta Anant Dessai et al.
Lacidipine, a calcium channel antagonist, is primarily used to treat hypertension. It is classified as a Biopharmaceutics Classification System Class II drug and exhibits an oral bioavailability of 10% due to its extensive hepatic first-pas...
Quality by Design Approach for Optimization of Microbial and pH-Triggered Colon-Targeted Tablet Formulation Using Carboxymethyl Tamarind Gum [0.03%]
一种基于质量优化的微生物设计方法，用于pH值触发结肠定位片剂制剂的研究（使用羧甲基塔拉胶）
Jaymin Patel,Kaushika Patel,Shreeraj Shah
Jaymin Patel
ABSTRACT The purpose of this study was to apply the quality by design (QbD) approach in the development of a microbial and pH-triggered colon-targeted budesonide tablet. A retrospective research strategy was used to select various polysacch...