Innovative Nanomaterials in Precision Oncology: Carbon Quantum Dots Driving Cancer Immunotherapy [0.03%]
精准肿瘤学中用于癌症免疫治疗的新型纳米材料：碳量子点
Hazha Omar Othman,Kovan Dilawer Issa,Diyar Salahuddin Ali et al.
Hazha Omar Othman et al.
Precision oncology aims to deliver individually tailored interventions in clinical management of cancers, which remain a global health challenge. Cancer immunotherapy is a field of precision oncology that can benefit from nanotechnology and...
Alterations in Gut Microbiota-Brain Axis in Major Depressive Disorder as Identified by Machine Learning [0.03%]
机器学习识别抑郁症患者肠道微生物群失调及其脑区功能异常
Atacan Deniz Oncu,Arzucan Ozgur,Kutlu O Ulgen
Atacan Deniz Oncu
Major depressive disorder (MDD) is a complex mental health condition whose causes may extend beyond purely biological explanations and are increasingly understood within wider ecological and social frameworks. Emerging research on the human...
Targeting Cyclin-Dependent Kinase 12 (CDK12) for Cancer Therapy: Structure-Based Discovery of Two Novel CDK12 Inhibitors In Silico Using Integrated Bioinformatics [0.03%]
基于结构的计算发现两种新型CDK12抑制剂用于癌症治疗：结合生物信息学综合方法针对细胞周期蛋白依赖性激酶12(CDK12)
Zehra,Lina I Alnajjar,Nawaf Alshammari et al.
Zehra et al.
Cyclin-dependent kinase 12 (CDK12) is thought to play an important role in cancer biology pathogenesis and development. Novel, selective, safe, and effective CDK12 inhibitors are actively sought after in drug discovery and clinical developm...
TFF3 Gene as a Molecular Target Potentially Shared by Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension: Drug Repurposing Prospect with Aminoglutethimide [0.03%]
特发性肺纤维化和肺动脉高压共有的分子靶点TFF3基因：用氨甲蝶呤老药新用的前景研究
Sanjukta Dasgupta
Sanjukta Dasgupta
Idiopathic pulmonary fibrosis (IPF) and pulmonary hypertension (PH) are two chronic conditions that can coexist occasionally, resulting in high morbidity and mortality. Despite their clinical association, the underlying genetic mechanisms a...
Prostate Cancer and Tea: CYP17A1 Inhibition by Phytochemicals from Tea Plant Camellia sinensis L. and Implications for Anti-androgenic Effect [0.03%]
茶与前列腺癌：茶植物Camellia sinensis L.中的植物化学成分对CYP17A1的抑制作用及其抗雄性素效果的意义
Aparna G Shenoy,Vishal Ravi,Riya Vishwakarma et al.
Aparna G Shenoy et al.
Camellia sinensis L., commonly known as the tea plant, produces derivatives such as green tea, which are among the most extensively consumed beverages worldwide. Green tea is rich in polyphenolic compounds, such as epigallocatechin-3-gallat...
A Systems Bioinformatics Analysis Indicates that Disruption of the lncRNA SFTA1P Network is Consistent with Impairing Surfactant Homeostasis and Respiratory Function Observed in Lung Adenocarcinoma [0.03%]
系统生物信息学分析表明，破坏lncRNA SFTA1P网络与肺腺癌中观察到的干扰表面活性剂稳态和呼吸功能一致
Firoz Ahmed,Yasir Mohamed Riza
Firoz Ahmed
Lung adenocarcinoma (LUAD) is one of the leading global health challenges wherein novel therapeutic targets are much needed. In this systems bioinformatics study, we report that disruption of the long noncoding RNA (lncRNA) SFTA1P-centered ...
Explaining Type 2 Diabetes with Transcriptomic Signatures of Pancreatic β-Cell Dysfunction and Death Induced by Human Islet Amyloid Polypeptide [0.03%]
利用人类胰岛淀粉样多肽诱导的胰岛β细胞功能障碍和死亡的转录特征解释2型糖尿病
Pratiksha H Roham,Saurabh Singh Yadav,Brindha Senthilnathan et al.
Pratiksha H Roham et al.
Amyloid deposits formed by misfolding and aggregation of human islet amyloid polypeptide (hIAPP) are one of the key pathophysiological features of type 2 diabetes mellitus (T2DM) and have been associated with the loss of function and viabil...
Dairy Cattle Reproduction, Production, and Disease Resistance in the Omics Era: Genome-Wide Selection Signatures Identify Candidate Genes in Sahiwal Cattle [0.03%]
组学时代奶牛繁殖、生产和抗病性研究：全基因组选择印记鉴定Sahiwal奶牛候选基因
Pradeep Chaudhary,Ankit Magotra,Rani Alex et al.
Pradeep Chaudhary et al.
Climate emergency and ecological sustainability call for new ways of thinking livestock health, including the dairy cattle. This study unpacks the genetic diversity and selection sweeps of Sahiwal cattle in relation to adaptability, product...
Drug Design in the Age of Network Medicine and Systems Biology: Transcriptomics Identifies Potential Drug Targets Shared by Sarcoidosis and Pulmonary Hypertension [0.03%]
网络医学和系统生物学时代的药物设计：转录组学确定了肺高血压与肉芽肿性疾病潜在的共有的药物作用靶点
Sanjukta Dasgupta
Sanjukta Dasgupta
Network medicine considers the interconnectedness of human diseases and their underlying molecular substrates. In this context, sarcoidosis and pulmonary hypertension (PH) have long been thought of as distinct diseases, but there is growing...
Rethinking River Buffalo Domestication Through the Lens of Population Genetics Tools: Mehsana Buffalo Is a Unique Population [0.03%]
通过群体遗传学工具重新思考河流水牛 domestication：Mehsana 水牛是一个独特的种群
Rangasai Chandra Goli,Kiyevi G Chishi,Karan Mahar et al.
Rangasai Chandra Goli et al.
Riverine buffalo domestication likely occurred around 6300 years ago in Northwestern India. Murrah and Surti are important buffalo breeds that originated in this region and the gene flow from these buffaloes to Mehsana buffalo has long been...