Joint Analysis of QTL Data Provided Insights into the Connection of Transcriptome and Proteome and the Impact of Omics Platforms [0.03%]
同时分析QTL数据可深入了解转录组与蛋白质组的关联及生物信息平台的影响
Majid Nikpay
Majid Nikpay
This study investigated the connection between the transcriptome and proteome by integrating eQTL (Expression Quantitative Trait Locus) and pQTL (Protein Quantitative Trait Locus) datasets generated using different technologies. eQTL data w...
Evaluation of Protein Preparation Methods for Quantitative Analysis of Pig Muscle Proteome [0.03%]
猪肌肉蛋白质组定量分析的蛋白制备方法评价
Didier Viala,Robin Maillet,Arnaud Delavaud et al.
Didier Viala et al.
High-throughput shotgun proteomics is often hindered by the incompatibility of detergents with mass spectrometry (MS), making sample preparation a critical bottleneck for accuracy and robustness. This challenge is amplified in muscle proteo...
Entropy-Guided Sample-Specific Feature Selection for Robust Incomplete Multi-Omics Learning in Gut Microbiome Disease Prediction and Biomarker Discovery [0.03%]
基于熵的样本特异性特征选择在肠道微生物组疾病预测和生物标志物发现中的稳健性Incomplete多组学学习中基于熵的样本特异性特征选择
Min Li,Kaixin Cheng,Mingzhu Lou et al.
Min Li et al.
The rapid advancement of multi-omics integration facilitates deep insights into complex diseases. However, incomplete modalities, heterogeneity, and high dimensionality hinder robust analysis. To address these limitations, we propose entrop...
Multi-Omics Evidence from Genetics Reveals an Association between the Hypoglycemic Drug Target DPP4 and Primary Ovarian Failure [0.03%]
遗传学多组学证据揭示降糖药靶点DPP4与原发性卵巢功能不全的相关性
Junyi Duan,Siqi Zhou,Shuyi Xu et al.
Junyi Duan et al.
Primary ovarian failure (POF) is linked to diabetes-related metabolic dysregulation, including inflammation, oxidative stress, and mitochondrial dysfunction. Summary-data-based Mendelian Randomization and colocalization analysis were employ...
Global Phosphoproteome Analysis Identifies CLK4 Co-Regulatory Pathways Driving Tumor-Specific Dysregulation [0.03%]
全球磷酸蛋白质分析鉴定出CLK4共调节通路驱动肿瘤特异性失调
Apoorva Pai,Leona Dcunha,Athira Perunelly Gopalakrishnan et al.
Apoorva Pai et al.
Dual-specificity protein kinase CLK4 plays a pivotal role in regulating alternative mRNA splicing, DNA repair, and various cellular processes through precise phosphorylation. In this study, we analyzed 3825 global human cellular phosphoprot...
Integrative Analysis of Hub Genes and miRNAs Reveals Inflammatory and Structural Signatures in Fibromyalgia and Their Modulation Following Manual Therapy [0.03%]
整合基因和微小核糖核酸的中心节点分析揭示了纤维肌痛的炎症及结构特征及其在手法治疗后的调节作用
Michele de Moura Gonçalves,Ariana Mendes Freire,Adriana Mary Mestriner Felipe de Melo et al.
Michele de Moura Gonçalves et al.
Fibromyalgia is a chronic pain syndrome characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive dysfunction, with substantial impact on quality of life and functional capacity. Despite its high prevalenc...
Human Extracellular Vesicles, Metabolites, and Metabolomics: A Comprehensive Review [0.03%]
人类 extracellular vesicle，代谢物和代谢组学的全面综述
Mohammed A Al-Zubaidi
Mohammed A Al-Zubaidi
Metabolomics is a powerful systems-level approach and has the potential to serve as an important part for understanding the biochemical pathways and metabolic phenotypes in physiological and pathological states. Extracellular vesicles (EVs)...
Integrative Biological Analysis of Histamine Depletion on Neuroinflammation, Dopamine D2 Receptor, and Glutamate in Experimental Tic Disorder [0.03%]
组胺耗竭对抽动障碍小鼠纹状体神经炎症、多巴胺D2受体和谷氨酸的影响及综合生物学分析
Jing Zhang,Qianying Liu,Shuyao Chen et al.
Jing Zhang et al.
Tic disorder (TD) is a common neurodevelopmental disorder in children. Acute histamine deficiency may be involved in the pathogenesis of TDs. In this study, we demonstrate that histamine depletion exacerbates tic-like behaviors in a rat mod...
Multiomics Integration Reveals Distinct miRNA-Mediated Regulatory Networks at the Transcript and Protein Levels in Idiopathic Pulmonary Fibrosis [0.03%]
多组学整合揭示特发性肺纤维化转录和蛋白质水平的miRNA介导的不同调控网络
Min Kyung Kim,Seung Hyun Kim,Sung Woo Park et al.
Min Kyung Kim et al.
MicroRNAs (miRNAs) are key post-transcriptional regulators implicated in multilevel molecular dysregulation in idiopathic pulmonary fibrosis (IPF). However, their function is largely inferred from miRNA-mRNA associations, leaving protein-le...
Synergistic Geroprotectors Mapping through Systems Machine Learning and Graph Neural Networks [0.03%]
基于系统机器学习和图神经网络的协同抗衰老药物筛选与机制研究
Yuvraj Sharma,Asmita Das
Yuvraj Sharma
Geroscience offers a transformative paradigm by targeting shared aging hallmarks to enable simultaneous modulation of multiple age-related disorders (ARDs). Yet, current geroprotective interventions often lack mechanistic breadth, as target...