Casting the Caspase Activity and Apoptosis Inhibitor 1 Phosphoregulation Through Global Phosphoproteomes [0.03%]
通过全球磷酸蛋白质组进行的针对半胱氨酸型天冬氨酸蛋白酶活性及凋亡抑制物-1磷酸调节的筛选
Pathiyil Sajini Sekhar,Amal Fahma,Athira Perunally Gopalakrishnan et al.
Pathiyil Sajini Sekhar et al.
Caspase Activity and Apoptosis Inhibitor 1 (CAAP1) is a regulatory protein known to suppress apoptosis and support cell survival with implications in cancer progression, cell migration, and angiogenesis, yet its regulation at the post-trans...
Integrative Transcriptomic Profiling Identifies TLR9 as a Key Biomarker of Diabetic Peripheral Neuropathy [0.03%]
整合转录组分析鉴定TLR9为糖尿病外周神经病变的关键生物标志物
Alekhya Bandi,Krishna Varshitha Maradihalli,Samyuktha Sunkara et al.
Alekhya Bandi et al.
Diabetic peripheral neuropathy (DPN) is a prevalent complication of type 2 diabetes that is typically diagnosed after irreversible nerve damage, largely due to the lack of molecular biomarkers that distinguish neuropathy-specific changes fr...
Neuromedin U Signaling Map: Toward Neuropeptide Focused Therapeutic Targets in Cancer and Human Diseases [0.03%]
神经调素U信号通路图：癌症和人类疾病中以神经肽为靶点的治疗方向
Leona Dcunha,Bhavana Edakkad,Isha Fathima et al.
Leona Dcunha et al.
Neuropeptides play pivotal roles in intercellular communication in the nervous system and peripheral tissues. However, the molecular events underlying their signaling lack a unified representation in the scientific literature. A case in poi...
Deciphering the Phospho-Signaling Network Associated with the Linker Region of Multidrug Resistance Protein 1 [0.03%]
解析多药耐药蛋白1连接区相关磷酸化信号网络
Revathy Nandakumar,Althaf Mahin,Athira Perunelly Gopalakrishnan et al.
Revathy Nandakumar et al.
The ATP-binding cassette subfamily C member 1 (ABCC1) is a key efflux pump that contributes to multidrug resistance in cancer by exporting chemotherapeutic agents and xenobiotics. Although ABCC1 is clinically important, the phosphorylation-...
A Comprehensive Analysis of Transcription Factor-microRNA Network in Six Different Major Cancers: Uncovering the Regulatory Backstages of Cancer [0.03%]
六种主要癌症中转录因子-microRNA网络的综合分析：揭示癌症调控背后的机制
Krishnapriya Ramakrishnan,Vishal Ravi,Rajesh Raju et al.
Krishnapriya Ramakrishnan et al.
Regulatory backstage of cancer involves complex multifactorial mechanisms. Among these, the posttranscriptional modulation between microRNA (miRNAs) and mRNAs is implicated as major regulatory mechanisms in different cancers. The tissue- an...
Reproducible and Multi-Study Transcriptomic Integration with disint, Disease Integration and Clustering Toolkit, and Application to Drug Repositioning [0.03%]
利用disint（疾病整合和聚类工具包）进行可重复的多研究转录组整合及其在药物再定位中的应用
Yi Cong,Naoki Osada,Toshinori Endo
Yi Cong
Integrating Big Data, such as large-scale transcriptomic datasets across diseases, continues to be a major challenge. This is in part due to inconsistent preprocessing and the lack of a standardized, reproducible analytical framework. Exist...
Phosphorylation-Dependent Regulation and Interactions of the Neutral Amino Acid Transporter SLC6A15: Implications for Major Depression and Neuropsychiatric Disorders [0.03%]
天冬氨酸转运蛋白SLC6A15的磷酸化调控及其相互作用在重大抑郁障碍和神经精神疾病中的意义
Jaytha Thomas,Fathimathul Lubaba,Suhail Subair et al.
Jaytha Thomas et al.
SLC6A15, (sodium-dependent neutral amino acid transporter B(0)AT2), plays a crucial role in amino acid homeostasis and neuronal signaling, and it has been genetically and transcriptionally associated with major depressive disorder (MDD). Ho...
Transcriptomic Correlation Identifies Cell Model Representatives for MYCN-Amplified Pediatric Neuroblastoma, Downstream Impact of Model Choice on Functional Interpretation, and Potential Drug Repositioning Candidates [0.03%]
转录组关联分析鉴定MYCN扩增阳性儿童神经母细胞瘤体外细胞模型代表性、模型选择对功能解释的影响及潜在药物再定位候选药物筛查
Simran Venkatraman,Pisut Pongchaikul,Brinda Balasubramanian et al.
Simran Venkatraman et al.
Neuroblastoma (NB) is the most common extracranial solid malignancy of children, and MYCN amplification defines a high-risk subtype with poor outcomes. Although widely used in preclinical drug discovery, NB cell lines are often selected bas...
How Can We Improve Subtyping of Colon Adenocarcinoma for Precision Oncology? Multi-Omics Consensus Clustering Reveals Immunologically Active and Therapeutically Distinct Molecular Groups [0.03%]
如何改进结肠腺癌的亚型分类以实现精准肿瘤学？多组学共识聚类揭示了具有不同免疫活性和治疗反应特征的分子亚群
Güllü Elif Özdemir,Kazim Yalcin Arga
Güllü Elif Özdemir
Colon adenocarcinoma (COAD) is a heterogeneous malignancy whose molecular complexity limits effective therapy. Existing transcriptome-based classifications capture only part of this diversity. To refine COAD stratification, we integrated ge...
Systems Biology of Mesial Temporal Lobe Epilepsy and Role of Iron-Related Gene Expression in Its Pathophysiology [0.03%]
内侧颞叶癫痫的系统生物学及其铁相关基因表达的作用
Divya Mundackal Sivaraman,Aisha Shaju,Geethu S Nair et al.
Divya Mundackal Sivaraman et al.
Mesial temporal lobe epilepsy (MTLE) is the most common form of drug-resistant epilepsy in adults, yet its molecular pathogenesis remains elusive. While iron dysregulation has been implicated in MTLE, transcriptome-level regulation of iron-...