Integrative Genomic and Immune Profiling to Identify and Characterize High-Risk Subgroups in Acute Myeloid Leukemia: Development of a 20-Gene Predictive Signature and Its Clinical Implications [0.03%]
整合基因组和免疫谱分析识别急性髓系白血病高危亚型并建立预后模型及临床意义
Kubra Karagoz,M Guy Roukens,Lizzy Comijn et al.
Kubra Karagoz et al.
Acute myeloid leukemia (AML) is a heterogeneous malignancy with diverse genetic mutations and oncogenic pathways influencing treatment response. Despite therapeutic advances, relapse and resistance remain persistent issues. This study integ...
How Do Hepatocyte MicroRNAs Play a Role in Hepatitis C Virus Replication and Pathogenesis? Emerging Hypotheses and Strategies for MicroRNA Therapeutics and Drug Development [0.03%]
肝细胞微小核糖核酸在丙型肝炎病毒复制及发病机制中的作用：新兴假设与微小核糖核酸疗法和药物研发策略
Sreeranjini Babu,Krishnapriya Ramakrishnan,Deepak Krishnan et al.
Sreeranjini Babu et al.
Hepatitis C virus (HCV) is a major global health burden affecting millions worldwide. A deeper understanding of and theories on the mechanisms of HCV replication and pathogenesis would bode well for diagnostics and therapeutics innovation. ...
Mast Cells Drive Ferroptosis in Gastric Tumors as Key Players in the Tumor Immune Microenvironment [0.03%]
胃肿瘤中的肥大细胞通过调节肿瘤免疫微环境驱动铁死亡发生
Fatma Sert,Ozlem Ulucan
Fatma Sert
Ferroptosis, an iron-dependent form of oxidative cell death, plays a critical role in cancer progression and immune regulation. However, the functional connections of ferroptosis with specific immune cell types remain poorly defined, limiti...
Letter: Integrating Omics for Future-Ready Plant Science: Reflections from the National Symposium on Recent Trends in Omics in Plant Biology, Held in Kozhikode, India [0.03%]
组学在植物生物学中的最新趋势全国研讨会会议来信：面向未来作物育种的组学集成（于印度科泽科德举行）
Sona Charles,Anees Kaprakkaden,Prasath Duraisamy et al.
Sona Charles et al.
Clinical and Genetic Predictors of Sickle Cell Nephropathy: A Global Systematic Review [0.03%]
镰状细胞肾病的临床和遗传预测因素：全球系统评价
Kambe Banda,Arthemon Nguweneza,Khuthala Mnika et al.
Kambe Banda et al.
Sickle cell disease (SCD) affects nearly 300,000 newborns annually worldwide, with 80% born in Africa. Sickle cell nephropathy (SCN) affects 5-18% of patients with SCD and contributes significantly to morbidity and mortality. Identifying SC...
A Gel-Free Genome Annotation Provides Insights into the Proteome of the Oomycete Phytophthora meadii, a Disease-Causing Pathogen in Economically Important Crops [0.03%]
一种无凝胶的基因组注释方法揭示了大豆疫霉病菌蛋白质组的见解
Bhagya Nekrakalaya,Chinmaya Narayana Kotimoole,Mohammad Arefian et al.
Bhagya Nekrakalaya et al.
Phytophthora meadii is a polyphagous oomycete causing fatal diseases in economically important cash crops such as rubber, arecanut, cardamom, and other crops and plants of economic significance. Although information on the proteogenomic and...
The Genome Sequence of the Rugose Spiraling Whitefly (Aleurodicus rugioperculatus Martin): Insights on Biology of an Invasive Agricultural Insect Pest and Implications for Pest Control [0.03%]
粗纹白带弄蝶基因组序列及其对入侵性农业害虫生物学研究及防治的启示
Rajesh Muliyar Krishna,Sujithra Maruthakasi,Josephrajkumar Arulappan et al.
Rajesh Muliyar Krishna et al.
The Rugose Spiraling Whitefly (RSW) (Aleurodicus rugioperculatus Martin), a pest native to Central America, infests coconut palms and has been introduced to other regions of the world including North America (e.g., Florida) and Southeast As...
Collagen Type 1 Alpha 1 Chain as a Potential Therapeutic Target Shared Among Subtypes of Head and Neck Squamous Cell Carcinoma: Quantum Chemical Modeling of Bleomycin for Anticancer Drug Repurposing [0.03%]
胶原蛋白1型 alpha 1链作为头颈部鳞状细胞癌各亚型的潜在治疗靶点：量子化学建模及bleomycin的抗癌药物再定位研究
Ashok Kumar,Jency Roshni,Mahema Sivakumar et al.
Ashok Kumar et al.
Head and neck squamous cell carcinoma (HNSCC) displays significant molecular heterogeneity, which hinders effective and safe treatments and clinical outcomes. This predicament also points to the need for an individually tailored personalize...
Unraveling the Microbiome-Asthma Axis: Metagenomic Insights from Airway and Gut Microbial Communities [0.03%]
解开微生物组-哮喘轴：来自呼吸道和肠道微生物群的元基因组学见解
Sanjukta Dasgupta
Sanjukta Dasgupta
Asthma is a heterogeneous respiratory disease with complex pathogenesis involving immune dysregulation, environmental triggers, and increasingly recognized to have contributions from the human microbiome. Emerging evidence from longitudinal...
Behavioral and Metabolomics Analyses of Drosophila melanogaster with Chronobiotic Melatonin Treatment: Effects on Locomotor Activity, Circadian Integrity, and Metabolic Pathways [0.03%]
基于生物节律的褪黑素治疗对果蝇运动活动、昼夜节律和代谢途径的影响：行为学及代谢组学分析
Apoorva Bhatnagar,Srishti Banerjee,Sandip Das et al.
Apoorva Bhatnagar et al.
Circadian rhythm and the sleep/wake cycle can influence metabolic regulation, eating habits, hormone release, and common chronic health conditions such as obesity, depression, diabetes, and sleep disorders. Drosophila melanogaster, the frui...