Integrative Transcriptomic and Metabolomic Analysis Reveals Aberrant Glycosylation as a Hallmark of Lung Adenocarcinoma [0.03%]
整合转录组和代谢组分析揭示异常糖基化为肺腺癌的标志
Sanjukta Dasgupta
Sanjukta Dasgupta
Lung adenocarcinoma (LUAD) remains the most common subtype of lung cancer, characterized by high heterogeneity and poor survival outcomes. Although transcriptomic and metabolomic alterations have been individually studied, integrated multi-...
Metabolomics in Idiopathic Pulmonary Fibrosis: Emerging Lessons for Chronic Lung Diseases and Opportunities for Clinical Translation [0.03%]
特发性肺纤维化代谢组学：慢性肺部疾病的新认识及临床转化机会
Sanjukta Dasgupta
Sanjukta Dasgupta
Idiopathic Pulmonary Fibrosis (IPF) is a progressive and fatal interstitial lung disease (ILD) characterized by abnormal epithelial cell behavior and excessive extracellular matrix deposition. Despite advances in understanding its molecular...
Vural Özdemir
Vural Özdemir
The Causal Relationship of Multiple Sclerosis on Serum Uric Acid Levels: A Mendelian Randomization Study [0.03%]
系统性硬化症与血清尿酸水平的因果关系：孟德尔随机化研究
Hyeok Kang,Seungyoon Nam
Hyeok Kang
Multiple sclerosis (MS) poses a significant challenge in global health, with increasing incidence rates and profound implications that transcend the geographical boundaries. Recent literature has explored the relationship between MS and ser...
Cancer Signaling Networks and the Phosphoregulatory Role of RAF1 Kinase [0.03%]
癌基因信号传导网络以及RAF1激酶的磷酸调节作用
Leona Dcunha,Bhavana Edakkad,Mejo George et al.
Leona Dcunha et al.
Cancer signaling networks play key roles in cancer pathogenesis and drug discovery. The RAS/RAF/MAPK pathway has a crucial role in cell biology and cancer progression, with Raf-1 proto-oncogene, serine/threonine kinase (RAF1) serving as a k...
Melanin Biosynthesis and Omics: Homogentisate Pathway Dysfunction Drives Pyomelanin Production in Mutant Bacillus thuringiensis var. israelensis MB-24 [0.03%]
黑色素生物合成与组学：对易变苏云金芽孢杆菌以色列变种MB-24来说，同雄色素途径功能障碍驱动吡黑素生成
Nikhil Bharadwaj,Jyothi Nenavath,Muthukumaravel Subramanian et al.
Nikhil Bharadwaj et al.
Melanin is a complex biopolymer with antioxidative, UV-protective, and antimicrobial properties. Melanin is also of interest for bioengineering applications in healthcare. Its production has been frequently observed in several bacteria and ...
Phospho-Regulatory Network of the Right Open Reading Frame Kinase 1 (RIOK1), Its Functional Relevance, and Cancer Treatment Prospects [0.03%]
右开放阅读框激酶1(RIOK1)的磷酸化调控网络及其功能和癌症治疗前景
Amal Fahma,Leona Dcunha,Suhail Subair et al.
Amal Fahma et al.
Right open reading frame kinase 1 (RIOK1) is an atypical kinase involved in ribosome biogenesis, cell cycle progression, and chromosome organization. Its overexpression is linked to tumor progression, metastasis, and chemoresistance, while ...
The Art of Critique [0.03%]
评论的艺术
Vural Özdemir
Vural Özdemir
A Bird's-Eye View of the Wings Apart-Like Protein in Cell Biology and Implications for Disease and Therapeutics [0.03%]
细胞生物学中的“翼分离”样蛋白概览及其对疾病和治疗的启示
Pathiyil Sajini Sekhar,Amal Fahma,Suhail Subair et al.
Pathiyil Sajini Sekhar et al.
Wings apart-like protein (WAPL) has emerged as a key player in maintaining genome integrity through its regulation of cohesin dynamics, which govern chromatin architecture and gene expression. WAPL mainly acts as a cohesin release factor an...
Toward Natural Products-Based Drug Development for Erectile Dysfunction: A Molecular Candidate from Plant Tribulus terrestris Identified by an Integrated In Silico Study [0.03%]
基于天然产物的男性性功能障碍药物研发：整合计算机辅助药物设计方法从植物中提取的有效分子候选者研究
Riya Vishwakarma,Abel John Koshy,Haritha Kalath et al.
Riya Vishwakarma et al.
Conventional pharmacological interventions for erectile dysfunction (ED) primarily rely on the phosphodiesterase-5 (PDE5) inhibitors such as sildenafil, tadalafil, vardenafil, and avanafil that have side effects despite their therapeutic ef...