Genetics of Chronic Shoulder Pain/Disability in South African Breast Cancer Survivors: Polygenic Contributions by Opioid and Pain Signaling Pathways [0.03%]
南非乳腺癌幸存者的慢性肩部疼痛/残疾的遗传学：阿片类药物和疼痛信号传导途径的多基因贡献
Firzana Firfirey,Delva Shamley,Alison V September
Firzana Firfirey
Chronic shoulder pain/disability is a significant cause of morbidity among breast cancer survivors, which can persist for several years postsurgery, thus markedly impacting their quality of life. The condition is a multifactorial and polyge...
Summary-data-based Mendelian Randomization Analysis Identifies Nominal Evidence for Association of N6-Methyladenosine Genetic Variation with Alzheimer's Disease [0.03%]
基于汇总数据的孟德尔随机化分析发现N6-甲基腺苷遗传变异与阿尔茨海默病存在名义上的关联证据
Md Rezanur Rahman,Yuanhao Yang,Jacob Gratten et al.
Md Rezanur Rahman et al.
N6-methyladenosine (m6A) is an abundant post-transcriptional RNA modification that critically regulates brain function. Dysregulation of m6A signaling has been implicated in several neurological diseases, including Alzheimer's disease (AD)....
Artificial Intelligence and Its Political and Critical Normative Implications [0.03%]
人工智能及其政治和批判性规范含义
Marco Boschele
Marco Boschele
Artificial intelligence (AI) marks an era in systems science when digital technologies are transforming big data-driven knowledge production and their applications toward public policy and governance including health care innovation, be the...
Integrative Multi-Omics and Artificial Intelligence: A New Paradigm for Systems Biology [0.03%]
整合多组学与人工智能：系统生物学的新范式
Shashi Kant,Deepika,Saheli Roy
Shashi Kant
The increasing accessibility of high-throughput omics technologies has represented a paradigm change in systems biology, facilitating the systematic exploration of biological complexity at genomic, transcriptomic, proteomic, and metabolomic...
Mastery of MAST3 Nonkinase Domain Phosphosites in Regulating Cytoskeletal Organization [0.03%]
MAST3非激酶区磷酸化位点在细胞骨架调控中的作用机制研究
Fathimathul Lubaba,Aswin Mohan,Althaf Mahin et al.
Fathimathul Lubaba et al.
Microtubule-associated serine/threonine-protein kinase 3 (MAST3) is a member of the MAST kinase family implicated in neuronal and immune pathways and is predicted to associate with cytoskeletal regulation. However, insights into its functio...
Vural Özdemir
Vural Özdemir
ImmFinder: A Multiomics-Based Neural Network Approach for Predicting the Immune Genes in Livestock [0.03%]
ImmFinder：一种基于多组学的神经网络方法预测家畜免疫基因
Menaka Thambiraja,Pavinap Priyaa Karthikeyan,Mezya Sezen et al.
Menaka Thambiraja et al.
The classification of immune and nonimmune genes in cattle is crucial for understanding immune mechanisms and their link to disease resistance. Traditional methods rely on manual curation and conventional bioinformatics tools, which are oft...
Pan-Cancer Analyses of Shared and Distinct Gene Expression in 17 Cancers: Rethinking Cancer Classification and Moving Beyond "One Drug, One Disease" Paradigm of Pharmaceutical Innovation [0.03%]
基于17种癌症的共享和特异性基因表达谱分析：重新思考肿瘤分类并超越“一个药物，一种疾病”的新药研发理念
Esra Gov,Aytac Gul
Esra Gov
Cancer is a disease with heterogenous molecular signatures that ought to be unpacked to achieve the overarching aim of precision oncology. A pan-cancer omics approach provides a systems science framework to explore shared and distinct mecha...