Reproducible and Multi-Study Transcriptomic Integration with disint, Disease Integration and Clustering Toolkit, and Application to Drug Repositioning [0.03%]
利用disint（疾病整合和聚类工具包）进行可重复的多研究转录组整合及其在药物再定位中的应用
Yi Cong,Naoki Osada,Toshinori Endo
Yi Cong
Integrating Big Data, such as large-scale transcriptomic datasets across diseases, continues to be a major challenge. This is in part due to inconsistent preprocessing and the lack of a standardized, reproducible analytical framework. Exist...
Phosphorylation-Dependent Regulation and Interactions of the Neutral Amino Acid Transporter SLC6A15: Implications for Major Depression and Neuropsychiatric Disorders [0.03%]
天冬氨酸转运蛋白SLC6A15的磷酸化调控及其相互作用在重大抑郁障碍和神经精神疾病中的意义
Jaytha Thomas,Fathimathul Lubaba,Suhail Subair et al.
Jaytha Thomas et al.
SLC6A15, (sodium-dependent neutral amino acid transporter B(0)AT2), plays a crucial role in amino acid homeostasis and neuronal signaling, and it has been genetically and transcriptionally associated with major depressive disorder (MDD). Ho...
Transcriptomic Correlation Identifies Cell Model Representatives for MYCN-Amplified Pediatric Neuroblastoma, Downstream Impact of Model Choice on Functional Interpretation, and Potential Drug Repositioning Candidates [0.03%]
转录组关联分析鉴定MYCN扩增阳性儿童神经母细胞瘤体外细胞模型代表性、模型选择对功能解释的影响及潜在药物再定位候选药物筛查
Simran Venkatraman,Pisut Pongchaikul,Brinda Balasubramanian et al.
Simran Venkatraman et al.
Neuroblastoma (NB) is the most common extracranial solid malignancy of children, and MYCN amplification defines a high-risk subtype with poor outcomes. Although widely used in preclinical drug discovery, NB cell lines are often selected bas...
How Can We Improve Subtyping of Colon Adenocarcinoma for Precision Oncology? Multi-Omics Consensus Clustering Reveals Immunologically Active and Therapeutically Distinct Molecular Groups [0.03%]
如何改进结肠腺癌的亚型分类以实现精准肿瘤学？多组学共识聚类揭示了具有不同免疫活性和治疗反应特征的分子亚群
Güllü Elif Özdemir,Kazim Yalcin Arga
Güllü Elif Özdemir
Colon adenocarcinoma (COAD) is a heterogeneous malignancy whose molecular complexity limits effective therapy. Existing transcriptome-based classifications capture only part of this diversity. To refine COAD stratification, we integrated ge...
Systems Biology of Mesial Temporal Lobe Epilepsy and Role of Iron-Related Gene Expression in Its Pathophysiology [0.03%]
内侧颞叶癫痫的系统生物学及其铁相关基因表达的作用
Divya Mundackal Sivaraman,Aisha Shaju,Geethu S Nair et al.
Divya Mundackal Sivaraman et al.
Mesial temporal lobe epilepsy (MTLE) is the most common form of drug-resistant epilepsy in adults, yet its molecular pathogenesis remains elusive. While iron dysregulation has been implicated in MTLE, transcriptome-level regulation of iron-...
Can We Develop Glioma Subtype-Specific Precision Medicines? An Integrative Machine Learning Pipeline for Biomarker Discovery and Drug Repurposing for Glioblastoma and Low-Grade Glioma [0.03%]
我们可以针对胶质瘤亚型开发精确药物吗？一种整合机器学习管线，用于发现和重新定位胶质母细胞瘤及低级别胶质瘤的生物标志物
Semra Melis Soyer,Elif Bengu Kizilay,Pemra Ozbek et al.
Semra Melis Soyer et al.
Glioma remains a major clinical challenge due to its molecular heterogeneity and limited therapeutic options. While numerous biomarker and drug discovery efforts exist, most are restricted by small sample sizes, subtype-agnostic analyses, o...
Immune-Suppressed, Not Immune-Cold: HMOX1-CD14-Immunoproteasome Axis and Structure-Guided Combination Pharmacotherapies in Isocitrate Dehydrogenase-Mutant Glioblastoma [0.03%]
免疫抑制，而非免疫荒漠：HMOX1-CD14-免疫蛋白酶体轴及结构导向联合药物治疗在异柠檬酸脱氢酶突变型胶质母细胞瘤中的作用
Sezin Gürkan Şali,Şeyma Çolakoğlu Özkaya,Betül Budak et al.
Sezin Gürkan Şali et al.
Glioblastoma (GBM) remains one of the most aggressive human malignancies, and its biological diversity is largely shaped by the isocitrate dehydrogenase (IDH) mutation status. Although apoptosis, autophagy, and ferroptosis have each been im...
Phosphoregulation for Therapeutic Interventions in Cancer? Phosphoregulatory Map of Checkpoint Kinase 1 (CHK1) Uncovers Unexplored Regulatory Layers [0.03%]
checkpoint kinase 1（chk1）磷酸化调控网络的绘制揭示了未知的作用位点和潜在的抗肿瘤治疗新策略
Mejo George,Leona Dcunha,Levin John et al.
Mejo George et al.
Checkpoint kinase 1 (CHEK1/CHK1) is a serine/threonine kinase that is pivotal in maintaining genomic stability by regulating DNA replication, mitotic progression, and DNA damage response (DDR). Phosphorylation at distinct regulatory sites o...
Transcriptome-Based Machine Learning Models to Predict Antimicrobial Resistance in Pseudomonas aeruginosa [0.03%]
基于转录组的机器学习模型预测铜绿假单胞菌抗微生物药物耐药性
Ceyda Kula,Irem Erguven,Berkay Ozcelik et al.
Ceyda Kula et al.
Antimicrobial resistance (AMR) is a growing threat in planetary health and demands innovative systems biology strategies for rapid and accurate detection of AMR and attendant resistance phenotypes. Chief among the AMR cases is Pseudomonas a...
What Drives Aggressiveness of Smoker Lung Adenocarcinoma? Potential Role of Nicotine-Responsive Neuropeptides Neurotensin and Calcitonin-Related Polypeptide Alpha [0.03%]
吸烟者肺腺癌侵袭性较强的原因是什么？神经紧张素和降钙素相关多肽α的潜在作用
Sanjukta Dasgupta
Sanjukta Dasgupta
Lung adenocarcinoma (LUAD) is the most prevalent subtype of nonsmall cell lung cancer. Cigarette smoking, the primary etiological factor, introduces mutagenic and epigenetic changes that promote tumorigenesis, with nicotine acting as a key ...