Integrated Computational Omics Approach to Identify Novel Natural Product Inhibitors Targeting KIF11 in Endometrial Carcinoma [0.03%]
整合组学计算方法鉴定宫体癌中针对KIF11的新天然产物抑制剂
Shazma Sarwat,Koel Mukherjee
Shazma Sarwat
Endometrial carcinoma (EC) presents a growing global health challenge, characterized by significant molecular heterogeneity and the overexpression of the mitotic motor protein Kinesin Family Member 11 (KIF11). To address the critical need f...
Metagenomics in Obstructive Lung Diseases: Insights into Microbial Dysbiosis, Host-Microbe Interactions, and the Gut-Lung Axis [0.03%]
宏基因组学在阻塞性肺疾病中的应用：探讨微生物群失调、宿主-微生物相互作用和肠-肺轴的作用
Sanjukta Dasgupta
Sanjukta Dasgupta
Obstructive lung diseases (OLDs), including asthma and chronic obstructive pulmonary disease (COPD), arise from complex interactions among microbial ecosystems, host immunity, metabolic regulation, and environmental exposures. Metagenomic a...
Genomic Sequencing from Sanger to Next-Generation Sequencing: Historical Context, Comparative Advances, and Prospects for Next-Generation Phenomics [0.03%]
从桑格到下一代测序：历史背景、比较优势和下一代表型组学的前景
Akash Ranga,Anvita Gupta Malhotra,Jitendra Singh et al.
Akash Ranga et al.
DNA sequencing has revolutionized biological and biomedical research, offering profound insights into genome organization, function, and variability. From the pioneering Sanger capillary electrophoresis method to the advent of next-generati...
K Shuvo Bakar
K Shuvo Bakar
Systems Biology of Metabolic Dysregulation in Ankylosing Spondylitis Using scRNA-Seq Data [0.03%]
利用单细胞 RNA 测序数据进行代谢失调的系统生物学研究以揭示强直性脊柱炎的发病机制
Merve Yarıcı,Muhammed Erkan Karabekmez
Merve Yarıcı
Ankylosing spondylitis (AS) is a prevalent autoimmune disorder that primarily affects the spinal joints, leading to chronic pain. Defining immune cell programs that contribute to AS is essential for the discovery of translational targets. B...
Casting the Caspase Activity and Apoptosis Inhibitor 1 Phosphoregulation Through Global Phosphoproteomes [0.03%]
通过全球磷酸蛋白质组进行的针对半胱氨酸型天冬氨酸蛋白酶活性及凋亡抑制物-1磷酸调节的筛选
Pathiyil Sajini Sekhar,Amal Fahma,Athira Perunally Gopalakrishnan et al.
Pathiyil Sajini Sekhar et al.
Caspase Activity and Apoptosis Inhibitor 1 (CAAP1) is a regulatory protein known to suppress apoptosis and support cell survival with implications in cancer progression, cell migration, and angiogenesis, yet its regulation at the post-trans...
Integrative Transcriptomic Profiling Identifies TLR9 as a Key Biomarker of Diabetic Peripheral Neuropathy [0.03%]
整合转录组分析鉴定TLR9为糖尿病外周神经病变的关键生物标志物
Alekhya Bandi,Krishna Varshitha Maradihalli,Samyuktha Sunkara et al.
Alekhya Bandi et al.
Diabetic peripheral neuropathy (DPN) is a prevalent complication of type 2 diabetes that is typically diagnosed after irreversible nerve damage, largely due to the lack of molecular biomarkers that distinguish neuropathy-specific changes fr...
Neuromedin U Signaling Map: Toward Neuropeptide Focused Therapeutic Targets in Cancer and Human Diseases [0.03%]
神经调素U信号通路图：癌症和人类疾病中以神经肽为靶点的治疗方向
Leona Dcunha,Bhavana Edakkad,Isha Fathima et al.
Leona Dcunha et al.
Neuropeptides play pivotal roles in intercellular communication in the nervous system and peripheral tissues. However, the molecular events underlying their signaling lack a unified representation in the scientific literature. A case in poi...
Deciphering the Phospho-Signaling Network Associated with the Linker Region of Multidrug Resistance Protein 1 [0.03%]
解析多药耐药蛋白1连接区相关磷酸化信号网络
Revathy Nandakumar,Althaf Mahin,Athira Perunelly Gopalakrishnan et al.
Revathy Nandakumar et al.
The ATP-binding cassette subfamily C member 1 (ABCC1) is a key efflux pump that contributes to multidrug resistance in cancer by exporting chemotherapeutic agents and xenobiotics. Although ABCC1 is clinically important, the phosphorylation-...
A Comprehensive Analysis of Transcription Factor-microRNA Network in Six Different Major Cancers: Uncovering the Regulatory Backstages of Cancer [0.03%]
六种主要癌症中转录因子-microRNA网络的综合分析：揭示癌症调控背后的机制
Krishnapriya Ramakrishnan,Vishal Ravi,Rajesh Raju et al.
Krishnapriya Ramakrishnan et al.
Regulatory backstage of cancer involves complex multifactorial mechanisms. Among these, the posttranscriptional modulation between microRNA (miRNAs) and mRNAs is implicated as major regulatory mechanisms in different cancers. The tissue- an...