piR-LGBM: A Sparse Autoencoder-Enhanced Gradient Boosting Framework to Uncover Disease-Associated piRNAs [0.03%]
piR-LGBM：一种稀疏自动编码器增强的梯度提升框架，用于揭示与疾病相关的piRNA
Aiswarya Mohan,Deepthi K
Aiswarya Mohan
Piwi-interacting RNAs (piRNAs) are a distinctive category of single-stranded, noncoding RNAs that are crucial for regulating gene expression. Recent studies have shown that piRNAs have a major role in regulating germ and stem cell developme...
Digital Resources for Traversing the Landscape of Human Aging: Databases, Key Computational Strategies, and Artificial Intelligence [0.03%]
数字化资源在人类衰老领域的研究进展：数据库、关键计算策略和人工智能技术
Aaysha Gupta,Sonam Chawla
Aaysha Gupta
By 2050, nearly 20% of the global population will exceed 60 years old, experiencing compromised physiological and functional abilities, neurological disorders, and sarcopenia. Geroscience has evolved immensely through OMICS approaches and h...
Integrative Proteomics Reveals Distinct Lipid Metabolic and Gut Microbiota-Associated Antidepressant Mechanisms of Two Herbal Medicines in a Chronic Stress Model [0.03%]
整合蛋白质组学揭示两种草药在慢性应激模型中独特的脂质代谢及肠道微生物相关抗抑郁作用机制
Jingxuan Tan,Linjie Li,Xixuan Li et al.
Jingxuan Tan et al.
Depression is a prevalent and disabling mental disorder associated with increased suicide risk and impaired quality of life. Herbal medicines such as Hypericum perforatum L. (St. John's Wort [SJW]) and Chaihu Shugan San (CSGS) have been wid...
Integrative Biology Approaches Uncover Plasticizers' Pro-Carcinogenic Role in Prostate Cancer via Molecular Docking and Network Toxicology [0.03%]
整合生物学方法通过分子对接和网络毒理学揭示增塑剂在前列腺癌中的促致癌作用
Jing Huang,Yumei Huang,Ying Huang et al.
Jing Huang et al.
Diethyl phthalate (DEP), dimethyl phthalate (DMP), and dioctyl phthalate (DOP) are common plasticizers. This study aimed to evaluate the potential roles of these plasticizers in the development of prostate cancer (PCa) via integrative biolo...
Network Pharmacological Analysis of Lentinan in Regulating Intervertebral Disc Degeneration: Combined with Machine Learning-Based Screening and Molecular Dynamics Validation [0.03%]
基于机器学习筛选及分子动力学验证的香菇多糖调节椎间盘退变的网络药理学研究
Hanhua Cai,Yihuang Chen,Huan Liu et al.
Hanhua Cai et al.
Lentinan (LNT) is a polysaccharide with antioxidant and anti-inflammatory properties; however, its link to intervertebral disc degeneration (IVDD) remains unclear. Here, we integrated network pharmacology, machine learning, molecular dockin...
Integrated Bioinformatics and Structural Assessment Suggest Doxycycline as a Potential Candidate Targeting MMP7 in Lung Cancer and SSc-Associated ILD [0.03%]
整合生物信息学和结构评估表明二甲胺四环素可能是肺癌和系统性硬化症相关间质性肺病中MMP7的潜在靶标候选药物
Sanjukta Dasgupta,Moupiya Ghosh,Sukhendu Sadhukhan et al.
Sanjukta Dasgupta et al.
Lung cancer (LC), particularly lung adenocarcinoma, is a leading cause of cancer-related mortality, while systemic sclerosis-associated interstitial lung disease (SSc-ILD) is a chronic fibrotic autoimmune disorder. Growing evidence suggests...
Uncovering Causal Links Between Autoimmune Diseases and Muscular Dystrophy: A Bidirectional Mendelian Randomization Study [0.03%]
自身免疫疾病和肌肉萎缩症间的因果关系探究：双向孟德尔随机化研究
Aytac Gul,Tugba Calisir,Hamdi Oguzman
Aytac Gul
Muscular dystrophies (MDs) are inherited neuromuscular disorders characterized by progressive muscle degeneration. Although their genetic causes are well known, the contribution of autoimmune diseases to MD risk remains unclear. To address ...
The Phosphoproteomic Landscape of CD2AP: A Comprehensive Review of Kinase Networks and Disease Implications [0.03%]
CD2AP磷酸化景观：激酶网络和疾病影响的全面回顾
Akhila Sheela,Suhail Subair,Athira Perunelly Gopalakrishnan et al.
Akhila Sheela et al.
CD2-associated protein (CD2AP) is a multifunctional adaptor linking membrane receptors to the actin cytoskeleton, ensuring slit diaphragm integrity, regulating synaptic proteostasis, and facilitating cytoskeletal remodeling. Dysregulation o...
Metabolomics at the Crossroads of Forensic Toxicology and Precision Diagnostics: Analytical Innovations and Translational Opportunities [0.03%]
代谢组学在法医毒理学和精准诊断交叉路口：分析创新与转化机遇
Palak Sharma,Anas Shamsi,Syed Tasqeeruddin et al.
Palak Sharma et al.
Metabolomics is the comprehensive analysis of small-molecule metabolites in living systems and is increasingly being applied in forensic science and health diagnostics. This review broadly integrates the foundational principles of metabolom...
Integrated Multiomics Analysis Suggests Statin-Associated Perturbation of DNA Repair Signaling in Colorectal Cancer Cells [0.03%]
整合多组学分析提示他汀药物通过干扰结直肠癌细胞DNA修复信号通路发挥作用
Francisco Alejandro Lagunas-Rangel
Francisco Alejandro Lagunas-Rangel
Statins are widely prescribed lipid-lowering agents that also exert pleiotropic anticancer effects, such as induction of apoptosis and ferroptosis, modulation of autophagy, and remodeling of the tumor microenvironment. Consistent with these...