ENTPD2 Transcript-Protein Divergence in Colorectal Cancer and Its Association with miR-708-5p: An Integrative Analysis [0.03%]
肠癌中ENTPD2的转录本-蛋白分歧及其与miR-708-5p关联的整合分析
Leyla Ataç Doğan
Leyla Ataç Doğan
Ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2), an enzyme involved in extracellular nucleotide metabolism and purinergic signaling, has been linked to tumor-immune interactions, although its role in colorectal cancer (CRC) remain...
Integrated Bioinformatics and Molecular Docking Analysis Reveals Potential Mechanisms of Coptidis Rhizoma in Intervertebral Disc Degeneration [0.03%]
基于分子对接的预测研究揭示了黄连防治椎间盘退变疾病的潜在机制
Chang-Ming Xiao,Kai-Quan Zhang,Yang Lei et al.
Chang-Ming Xiao et al.
Intervertebral disc degeneration (IVDD) is a major contributor to chronic low back pain and involves extracellular matrix degradation, inflammation, oxidative stress, and immune cell infiltration. This study integrated transcriptomic analys...
Site-Specific Phosphoproteomics Uncovers Potential Regulatory Networks of NEK4 in DNA Damage Response and Cancer Progression [0.03%]
定位组磷酸蛋白质组学揭示NEK4在DNA损伤反应和癌症进展中的潜在调控网络
Spoorthi Sathish Kashipatna,Apoorva Pai,Leona Dcunha et al.
Spoorthi Sathish Kashipatna et al.
NIMA-related kinase 4 (NEK4) is a serine/threonine kinase implicated in microtubule stabilization, cilia function, and DNA damage response (DDR), with emerging roles in cancer progression through context-dependent effects on proliferation, ...
Network-Based Multiomics Integration Reveals Immunometabolic Convergence Between COVID-19 and Pulmonary Arterial Hypertension [0.03%]
基于网络的多组学整合揭示了COVID-19与肺动脉高压之间的免疫代谢趋同性
Defne Cig Kabakcioglu,Ceyda Kasavi
Defne Cig Kabakcioglu
Coronavirus disease 2019 and pulmonary arterial hypertension (PAH) are clinically distinct disorders that converge on severe pulmonary vascular dysfunction, endothelial injury, and cardiopulmonary failure. However, the shared systems-level ...
Procaterol Enhances Cisplatin-Induced Cytotoxicity via Apoptosis, Oxidative Stress, and Cell Cycle Arrest in Breast and Cervical Cancer Cells [0.03%]
普拉卡洛尔通过促进凋亡、氧化应激和细胞周期阻滞来增强顺铂对乳腺癌和宫颈癌细胞的细胞毒作用
Neha Sajwani,Giridhara Prema Suchitha,T S Keshava Prasad et al.
Neha Sajwani et al.
Breast and cervical cancers remain significant causes of cancer-related deaths in women, necessitating the development of effective treatments. This study investigated the repositioning potential of procaterol as a chemosensitizer to increa...
Nikita Choudhary,Akhila Balakrishna Rai,Thottethodi Subrahmanya Keshava Prasad et al.
Nikita Choudhary et al.
Malaria caused by Plasmodium falciparum remains a health burden worldwide due to drug resistance and limited treatment options. Calcium-dependent protein kinase 1 (CDPK1) plays a central role in parasite development and invasion, but the do...
Investigating Immune Microenvironment of Inflammatory Bowel Disease and the Mitochondrial Metabolism-Related Molecular Mechanisms: Combining a Multiomics Approach and Experimental Validation [0.03%]
探究炎症性肠病免疫微环境及线粒体代谢相关分子机制：多组学结合实验验证
Hao Li,Xichuan Wu,Qingping Wu et al.
Hao Li et al.
Inflammatory bowel disease (IBD) is a chronic and recurrent gastrointestinal disease, the pathogenesis of which has not been fully elucidated. Increasing evidence suggests that the disorder of mitochondrial metabolism is closely related to ...
Genome-Wide Association Study Identifies Human Genetic Variants Associated with Systemic Chronic Inflammation [0.03%]
全基因组关联研究鉴定出与慢性全身性炎症相关的遗传变异
Jiayi Xue,Wenxin Sun,Peipei Liu et al.
Jiayi Xue et al.
Chronic low-grade inflammation has been identified as the etiology of disease across the life span; however, the underlying genetic mechanism are poorly understood, and no genetic association study is performed. Here, we quantified chronic ...
Exploring the ROS-Related Therapeutic Mechanism of Bushen Huoxue Decoction in Postmenopausal Osteoporosis through Transcriptomics and Network Pharmacology [0.03%]
基于转录组学和网络药理学的补肾活血方治疗绝经后骨质疏松症的ROS相关机制探讨
Li Yin,Xin Chen,Jianli Xu
Li Yin
Introduction: Postmenopausal osteoporosis (PMOP) involves bone loss and fracture risk, driven by estrogen deficiency, oxidative stress, immune dysregulation, and endocrine alterations. Bushen Huoxue Decoction is used for ...
Multiomics Analysis Identifies Candidate Molecular, Microbiota, and Metabolite Features Associated with Acute Myocardial Infarction Combined with Chronic Renal Failure [0.03%]
多组学分析确定与急性心肌梗死合并慢性肾功能衰竭相关的候选分子、微生物群和代谢物特征
Huijing Li,Huiqiong Li,Rongjing Wu et al.
Huijing Li et al.
Chronic renal failure (CRF) is a major risk factor for acute myocardial infarction (AMI) progression and poor outcomes, but the molecular, microbial, and metabolic features of AMI combined with CRF remain unclear. In this study, four Gene E...