Rémy Bosviel,Julie Durif,Jiaoli Guo et al.
Rémy Bosviel et al.
In silico prediction of drug targets in phytopathogenic Pseudomonas syringae pv. phaseolicola: charting a course for agrigenomics translation research [0.03%]
豆科植物病原菌Pseudomonas syringae pv. phaseolicola的药物靶点的计算机预测：为农业基因组学转化研究绘制蓝图
Pramod Katara,Atul Grover,Vinay Sharma
Pramod Katara
Pseudomonas syringae pv. phaseolicola is a major plant pathogen causing halo blight disease and has world-wide importance. The emerging post-genomics field of agrigenomics, together with the availability of whole genome sequences of a numbe...
A catalogue of glioblastoma and brain MicroRNAs identified by deep sequencing [0.03%]
利用深度测序技术鉴定胶质母细胞瘤及脑组织的MicroRNA目录
Dasong Hua,Fan Mo,Dong Ding et al.
Dasong Hua et al.
Glioblastoma is the most common and aggressive primary brain tumor. MicroRNAs (miRNAs) are a set of noncoding RNA of about 20∼22 nt in length and they play regulatory roles such as regulating the expression of proteins. Altered miRNA expre...
Identifying grade/stage-related active modules in human co-regulatory networks: a case study for breast cancer [0.03%]
人类共调控网络中与分级/分期相关的活性模块的鉴定——乳腺癌病例研究
Chenchen Feng,Lina Chen,Wan Li et al.
Chenchen Feng et al.
The histological grade/stage of tumor is widely acknowledged as an important clinical prognostic factor for cancer progression. Recent experimental studies have explored the following two topics at the molecular level: (1) whether or not ge...
Analysis of in vivo function of predicted isoenzymes:a metabolomic approach [0.03%]
预测异构酶的体内功能分析：一种代谢组学方法
Suma Choorapoikayil,Jan Schoepe,Sebastian Buchinger et al.
Suma Choorapoikayil et al.
Isoenzymes occur in all organisms. Often, they are regulated with respect to environmental perturbations to assure metabolic flexibility. In bioinformatics-driven functional genome annotations, the presence of isoenzymes is frequently predi...
Gender-dependent associations of metabolite profiles and body fat distribution in a healthy population with central obesity: towards metabolomics diagnostics [0.03%]
性别依赖性代谢组谱型与中心性肥胖健康人群体脂分布的相关性：基于代谢组学的诊断方法研究
Ewa Szymańska,Jildau Bouwman,Katrin Strassburg et al.
Ewa Szymańska et al.
Obesity is a risk factor for cardiovascular diseases and type 2 diabetes especially when the fat is accumulated to central depots. Novel biomarkers are crucial to develop diagnostics for obesity and related metabolic disorders. We evaluated...
Pharmacogenetics of osteoporosis: towards novel theranostics for personalized medicine? [0.03%]
骨质疏松症的药物基因组学：迈向新型个体化医疗的诊疗一体方法？
Karen Rojo Venegas,Margarita Aguilera Gómez,Marisa Cañada Garre et al.
Karen Rojo Venegas et al.
Osteoporosis is a complex multifactorial bone disorder with a strong genetic basis. It is the most common, severe, progressive skeletal illness that has been increasing, particularly in developed countries. Osteoporosis will no doubt consti...
Nele Friedrich,Kathrin Budde,Tillmann Wolf et al.
Nele Friedrich et al.
Bariatric surgery leads to a loss of excess weight and to a remission of diabetes in a majority of patients. In an attempt to explain these underlying mechanisms, a broad range of metabolic alterations have been suggested. We aimed to inves...
Pharmacogenetic polymorphisms contributing to toxicity induced by methotrexate in the southern Spanish population with rheumatoid arthritis [0.03%]
南方西班牙类风湿关节炎患者甲氨蝶呤诱发毒性的药物基因多态性研究
José Cristian Plaza-Plaza,Margarita Aguilera,Marisa Cañadas-Garre et al.
José Cristian Plaza-Plaza et al.
Abstract Rheumatoid arthritis (RA) is a common illness of global significance for public health. Methotrexate (MTX) is the most broadly used disease-modifying antirheumatic drug for the treatment of RA, but it displays marked person-to-pers...
Analysis of possible mechanisms accounting for raf-1 kinase inhibitor protein downregulation in hepatocellular carcinoma [0.03%]
肝癌中RAF-1激酶抑制蛋白下调的可能机制分析研究
Paola Poma,Manuela Labbozzetta,Nicoletta Vivona et al.
Paola Poma et al.
Abstract Raf-1 kinase inhibitor protein (RKIP) is a tumor and metastasis suppressor that promotes drug-induced apoptosis in cancer cells. It is frequently downregulated, both at the mRNA and protein level, in hepatocellular carcinoma (HCC),...