Whole Exome Sequencing Helps Diagnose Familial Anophthalmia in Zimbabwe: A Call from the Field to Fund Clinical Genomics for Planetary Health [0.03%]
全外显子组测序有助于诊断津巴布韦的家族性无眼症：来自第一线的声音，呼吁为临床基因组学和 planetary health 研究提供资金支持
Nosipho Mabizela,Nyarai D Soko,Louisa R C Mudawarima et al.
Nosipho Mabizela et al.
Anophthalmia is the most severe ocular malformation inherited in an autosomal, X-linked, recessive, or dominant form. We report here the use of whole exome sequencing (WES) to help the clinical diagnosis of familial anophthalmia in Harare, ...
Let's Not Neglect Drug Discovery to Combat COVID-19: In Silico Study of the Anti-Cancer Compounds Flexible Heteroarotinoids as Candidate Inhibitors Against SARS-CoV-2 Proteins [0.03%]
别忽视药物研发来对抗COVID-19：关于抗癌症化合物Flexible Heteroarotinoids作为SARS-CoV-2蛋白质候选抑制剂的计算机模拟研究
Sujan Timsina,Masrur Akhter,Donghua H Zhou
Sujan Timsina
The COVID-19 pandemic phase caused by the SARS-CoV-2 has ended, but the emergence of new variants continues to threaten public health. The public health toolbox for COVID-19 is in need of not only vaccines but also drug discovery against th...
Identification of Overlapping Genetic Signatures Between Obstructive Sleep Apnea and Lung Cancer: Moving Beyond "One Drug, One Disease" Paradigm of Pharmaceutical Innovation [0.03%]
阻塞性睡眠呼吸暂停和肺癌之间重叠的遗传特征鉴定：“一个药物，一种疾病”的制药创新理念之外的目光
Sanjukta Dasgupta
Sanjukta Dasgupta
Traditional paradigms of pharmaceutical innovation have long relied on the "one drug, one disease" premise. However, a network mindset in unpacking disease mechanisms can be fruitful to move toward a "one drug, polydisease" paradigm of drug...
Harnessing Human Holobiome and Meta-Multi-Omics Analyses for Medical Applications [0.03%]
利用人类人体生物圈和元多组学分析进行医学应用
Muhammed Erkan Karabekmez
Muhammed Erkan Karabekmez
Next-generation sequencing technology has revolutionized all fields of living systems, and its applications almost reinvented some research areas including metagenomics. The microbiotas in our body, including those of the oral, nasal, ocula...
Theranostic Target NSUN2, a C(5)-Methyltransferase, Phospho-Regulatory Network Uncovered with Systematic Assembly of 805 Datasets [0.03%]
治疗性靶点NSUN2（一种C(5)甲基转移酶）及其磷酸调控网络通过系统整合805个数据集揭示出来
Fathimathul Lubaba,Mejo George,Mukhtar Ahmed et al.
Fathimathul Lubaba et al.
The RNA cytosine C(5)-methyltransferase NSUN2 is involved in RNA modification and regulates gene expression and genomic stability. Beyond multiple sequence/copy number variations, NSUN2 displays altered phosphoprotein expression in various ...
Orchestrating Intracellular Calcium Signaling Cascades by Phosphosite-Centric Regulatory Network: A Comprehensive Analysis on Kinases CAMKK1 and CAMKK2 [0.03%]
磷蛋白为中心的调控网络协调细胞内钙信号级联：对CAMKK1和CAMKK2激酶的综合分析
Althaf Mahin,Athira Perunelly Gopalakrishnan,Mukhtar Ahmed et al.
Althaf Mahin et al.
Intracellular calcium signaling is a cornerstone in cell biology and a key molecular target for human health and disease. Calcium/calmodulin dependent protein kinase kinases, CAMKK1 and CAMKK2 are serine/threonine kinases that contribute to...
Genome-Scale Metabolic Modeling of Human Pancreas with Focus on Type 2 Diabetes [0.03%]
人类胰腺的基因组规模代谢建模在2型糖尿病方面的研究焦点
Mustafa Sertbas,Kutlu O Ulgen
Mustafa Sertbas
Type 2 diabetes (T2D) is characterized by relative insulin deficiency due to pancreatic beta cell dysfunction and insulin resistance in different tissues. Not only beta cells but also other islet cells (alpha, delta, and pancreatic polypept...
Seven Hub Genes Associated with Huntington's Disease and Diagnostic and Therapeutic Potentials Identified by Computational Biology [0.03%]
计算生物学发现的七个与亨廷顿病相关的中心基因及诊断和治疗潜能
Afzal Hussain,Taj Mohammad,Shumayila Khan et al.
Afzal Hussain et al.
Huntington's disease (HD) is characterized by progressive motor dysfunction and cognitive decline. Early diagnosis and new therapeutic targets are essential for effective interventions. We performed integrative analyses of mRNA profiles fro...
Effect of Genetic Ancestry on Phenotypes and Genotypes in Papillary Thyroid Cancer [0.03%]
乳头状甲状腺癌的表型和基因型中基因祖先的影响
Shun-Yu Chi,Yi-Chiung Hsu,Shih-Ping Cheng
Shun-Yu Chi
Thyroid cancer (THCA) is a prevalent health burden, and unpacking its biological and social determinants is a public health priority. Previous studies have reported inconsistent findings regarding the effects of race and ethnicity on the in...
Innovations in Core-Shell Nanoparticles: Advancing Drug Delivery Solutions and Precision Medicine [0.03%]
核壳纳米粒子的创新：推进药物传输解决方案和精准医学发展
Suren A Ramadhan,Diyar S Ali
Suren A Ramadhan
Drug delivery innovation is an important pillar of systems pharmacology wherein nanotechnology offers significant prospects. This expert review examines and unpacks how core-shell nanoparticles (NPs) could revolutionize drug delivery system...