An Independent Evaluation of a Novel Peptide Mimetic, Brilacidin (PMX30063), for Ocular Anti-infective [0.03%]
布拉西丁(PMX30063)治疗眼部感染的独立评估研究
Regis P Kowalski,Eric G Romanowski,Kathleen A Yates et al.
Regis P Kowalski et al.
Objective: Brilacidin (BRI), a novel defensin mimetic, was evaluated as an ocular anti-infective. Methods: In vitro: Potency based on M...
Preformulation Studies of a Liposomal Formulation Containing Sirolimus for the Treatment of Dry Eye Disease [0.03%]
西罗莫司脂质体治疗干眼病的药学研究
Mónica Anayántzin Linares-Alba,Magda Berenice Gómez-Guajardo,Joice Furtado Fonzar et al.
Mónica Anayántzin Linares-Alba et al.
Purpose: The aim of this study was to develop and characterize a liposomal product containing sirolimus to be administered subconjunctivally for the treatment of nonresponsive keratoconjunctivitis sicca (KCS) or dry eye. ...
In Vitro and In Vivo Evaluation of Cidofovir as a Topical Ophthalmic Antiviral for Ocular Canine Herpesvirus-1 Infections in Dogs [0.03%]
用于治疗犬疱疹病毒-1型感染的西多福韦眼用凝胶的体外和体内评估研究
Eric C Ledbetter,Chloe B Spertus,Matthew R Pennington et al.
Eric C Ledbetter et al.
Purpose: The effects of cidofovir were investigated against canine herpesvirus-1 (CHV-1) in vitro and in dogs with experimentally induced recurrent ocular CHV-1 infection, a host-adapted pathogen animal model of ocular he...
Effect of Brimonidine on the B Cells, T Cells, and Cytokines of the Ocular Surface and Aqueous Humor in Rat Eyes [0.03%]
溴莫尼定对大鼠眼球表面B细胞、T细胞及房水细胞因子的影响
Hye-Young Shin,Hyun-Seung Lee,Young Chun Lee et al.
Hye-Young Shin et al.
Purpose: One serious ocular side effect associated with the long-term use of topical brimonidine tartrate is anterior uveitis. This study investigated the changes in the levels of several inflammatory cytokines, B cells, ...
TSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren's Syndrome Pathogenesis [0.03%]
TSP-1缺乏改变眼部微生物群：对Sjögren综合征发病机制的意义
Marielle Terzulli,Laura Contreras-Ruiz,Abirami Kugadas et al.
Marielle Terzulli et al.
Purpose: The potential role of commensals as triggering factors that promote inflammation in dry eye disease has not been explored. The objective of this study was to evaluate whether ocular microbiota changes with the on...
Joanne E Murphy-Ullrich,J Crawford Downs
Joanne E Murphy-Ullrich
Glaucoma is characterized by abnormal remodeling of the extracellular matrix (ECM) in the trabecular meshwork and in the connective tissue beams of the lamina cribrosa (LC) at the optic nerve head (ONH), which is associated with axonal dama...
Jennifer N Sims,Jack Lawler
Jennifer N Sims
Ocular angiogenesis is one of the underlying causes of blindness and vision impairment and may occur in a spectrum of disorders, including diabetic retinopathy, neovascular age-related macular degeneration, retinal artery or vein occlusion,...