Posterior Segment Drug Delivery Devices: Current and Novel Therapies in Development [0.03%]
后段眼用给药装置：目前及在研的新型疗法
Pooja Bansal,Satpal Garg,Yograj Sharma et al.
Pooja Bansal et al.
Ocular drug delivery by conventional routes of administration does not maintain therapeutic drug concentrations in the target tissues for a long duration because of various anatomical and physiological barriers. Treatment of diseases of the...
Comparative Study Between Lidocaine Gel 2% and 5% for Ophthalmic Procedures [0.03%]
2%与5%利多卡因凝胶用于眼科手术的比较研究
Hélio Francisco Shiroma,Kleber Eidi Shimono,Michel Eid Farah et al.
Hélio Francisco Shiroma et al.
Purpose: To compare same-day pain control and safety of 2 different anesthetic gels utilizing 5% and 2% lidocaine gel. Main outcome is to determine whether 5% lidocaine gel is more effective in decreasing pain during conj...
Frequent Dosing of Topical Cyclosporine A for Severe Ocular Surface Disease [0.03%]
频繁使用环孢素A滴眼液治疗严重的眼表疾病
Anisa I Gire,Sezen Karakus,Shanna M Ingrodi et al.
Anisa I Gire et al.
Purpose: To study the systemic safety and patient tolerability of frequent dosing of cyclosporine A (CsA) 0.05% eyedrops in the treatment of ocular surface disease. This is a retrospective case series. Patients with signi...
5-Fluorouracil-Induced Apoptosis Changes in Cultured Corneal Epithelial Cells [0.03%]
5-氟尿嘧啶诱导角膜上皮细胞凋亡的实验研究
Kwou-Yeung Wu,Yu-Hung Lai,Yu-Chiao Yang et al.
Kwou-Yeung Wu et al.
Purpose: Repeated subconjunctival injections with 5-fluorouracil (5-FU) after trabeculectomy are used in glaucoma patients for the inhibition of overproliferation in wound site. Thus, a certain amount of the drug may pene...
Pharmacokinetics of Melphalan After Intravitreal Injection in a Rabbit Model [0.03%]
经玻璃体给药后美法仑的药代动力学（兔模型）
Emiliano Buitrago,Ursula Winter,Gustavo Williams et al.
Emiliano Buitrago et al.
Purpose: Although widely used for vitreous seed control in retinoblastoma patients, currently there are no data on melphalan pharmacokinetics after intravitreal injections. Therefore, in this study, we characterized the o...
Oral Administration of Forskolin, Homotaurine, Carnosine, and Folic Acid in Patients with Primary Open Angle Glaucoma: Changes in Intraocular Pressure, Pattern Electroretinogram Amplitude, and Foveal Sensitivity [0.03%]
葛根素、同牛磺酸、卡尼丁和叶酸治疗原发性开角型青光眼患者的临床观察：房水流出量及模式 electroretinogram 和黄斑部阈值变化的改变
Maria Giulia Mutolo,Giuseppe Albanese,Dario Rusciano et al.
Maria Giulia Mutolo et al.
Purpose: To evaluate the effects of a food supplement containing forskolin, homotaurine, carnosine, folic acid, vitamins B1, B2, B6, and magnesium in patients with primary open angle glaucoma (POAG) already in treatment a...
Efficacy of Antibody Delivery to the Retina and Optic Nerve by Topical Administration [0.03%]
通过局部给药将抗体输送到视网膜和optic nerve的效果
Stacy Hu,Steven Koevary
Stacy Hu
Purpose: The purpose of this study was to determine whether nonspecific and ICAM-1-specific IgG1 antibodies can accumulate in the rat retina following topical application, and to develop a model system to show that antibo...
Comparison of the Anti-Inflammatory Effects of Artificial Tears in a Rat Model of Corneal Scraping [0.03%]
比较人工泪液的抗炎效果的小鼠角膜擦伤模型中的比较研究
Philippe Daull,Laurence Feraille,Pierre-Paul Elena et al.
Philippe Daull et al.
Purpose: Artificial tears (ATs) are used routinely to alleviate the symptoms of mild to moderate dry eye. Preservative-free cationic emulsions (eg, Cationorm(®)) are an innovative approach for the management of signs and...