Kindlin-2/Otub1/Slc7a11 Axis Improved Cardiac Ischemia Reperfusion Injury by Inhibiting Cardiomyocyte Ferroptosis [0.03%]
Kindlin-2/Otub1/Slc7a11轴通过抑制心肌细胞铁死亡改善心脏缺血再灌注损伤
Yuechao Dong,Fan Wu,Kuiwu Liu et al.
Yuechao Dong et al.
Aims: The study aimed to determine if the Kindlin-2/Otub1/Slc7a11 cascade could improve cardiac ischemia reperfusion injury by inhibiting ferroptosis. Results: The cardiac tissues of ischemia - reperfusion (I/R) mice, ischemic cardiomyopath...
Circular RNA-Directed Therapeutic Strategy for Cold-Induced Diabetic Macrovascular Disease [0.03%]
圆RNA指导的冷诱导糖尿病巨血管病治疗策略
Nan Jia,Kangling Xie,Cui Li et al.
Nan Jia et al.
Aims: This study aims to elucidate the molecular mechanisms underlying the alleviation of cold-climate-induced diabetic macrovascular disease (DM-MVD) by targeting hsa_circ_0010154 with gold nanoparticles (AuNPs)-mediated antisense oligonuc...
Epstein-Barr Virus Hijacks Redox Signaling via Glutathione Peroxidase 4 to Sustain Latency and Drive Gastric Cancer Progression [0.03%]
EB病毒通过劫持谷胱甘肽过氧化物酶4的抗氧化信号来维持潜伏并促进胃癌进展
Duo Shi,Yanhong Zhao,Xia Zhao et al.
Duo Shi et al.
Aims: Epstein-Barr virus (EBV)-associated gastric cancer (GC) accounts for about 9% of GC patients, but its pathogenesis remains unclear. Glutathione peroxidase 4 (GPX4) is an important antioxidant enzyme that is highly expressed in various...
Redox Regulation of Microvascular Physiology and Pathophysiology: Insights into Therapeutic Strategies and Limitations [0.03%]
微血管生理和病理生理的氧化还原调节：治疗策略的见解和局限性
David A Bulger,Zhan Zhang,Ruinan Hu et al.
David A Bulger et al.
Significance: Oxidative mechanisms contribute to both vascular function and pathogenesis of many diseases, but their role in the microvasculature remains poorly understood. Recent Advances: The role of reactive oxygen and reactive nitrogen ...
Endothelial Gasdermin D Induces Mitochondrial Damage and Activates the STING Pathway in Lipopolysaccharide-Accelerated Atherosclerosis [0.03%]
内皮细胞Gasdermin D诱导线粒体损伤并激活脂多糖加速的动脉粥样硬化中的STING通路
Xiaoyue Song,Junqiang Xue,Enyong Su et al.
Xiaoyue Song et al.
Aims: Chronic inflammation is a widely acknowledged contributor to the development of atherosclerosis. Gasdermin D (GSDMD) serves as a key executor of pyroptosis in inflammatory diseases. This study aims to determine the role of endothelial...
Empagliflozin Attenuates Diabetic Cardiomyopathy via Inhibiting Cardiomyocyte Ferroptosis Through the USP7/NRF2 Signaling Pathway [0.03%]
恩格列净通过USP7/NRF2信号通路抑制心肌细胞铁死亡来改善糖尿病心肌病
Min Cui,Junwei Zhang,Ziwei Wang et al.
Min Cui et al.
Aims: Diabetic cardiomyopathy (DbCM) typically manifests as diastolic dysfunction, and treating heart failure with preserved ejection fraction (HFpEF) is challenging. Empagliflozin (Empa), a sodium-glucose cotransporter 2 inhibitor, reduces...
CircGNAQ Promotes Intracranial Aneurysm Formation by Facilitating Vascular Smooth Muscle Cell Phenotypic Switching and Apoptosis [0.03%]
环状rna Circgnaq 通过促进血管平滑肌细胞表型转换及凋亡参与颅内动脉瘤形成
Han Zhou,Chao Wang,Wentao Wang et al.
Han Zhou et al.
Aims: Intracranial aneurysm (IA) is a critical cerebrovascular disorder strongly linked to phenotypic switching and apoptosis of vascular smooth muscle cells (VSMCs). This study aimed to investigate the role of circGNAQ in IA development an...
Nimodipine Blocks Histone-Induced Calcium Overload to Protect Neurons after Traumatic Brain Injury [0.03%]
尼莫地平通过阻断组蛋白诱发的钙超载保护创伤性脑损伤后神经元功能
Wei Cao,Yunfeng Xu
Wei Cao
Aims: To investigate if nimodipine alleviates traumatic brain injury (TBI)-induced neuronal apoptosis and neurological deficits by inhibiting extracellular histone-mediated Ca2+ influx, mitochondrial damage, and Caspase pathway activation. ...
Cystathionine γ-Lyase Protects Against Choline-Deficient High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Through the Cysteine-Glutathione Axis in Mice [0.03%]
胱硫醚-γ-裂解酶通过半胱氨酸-谷氨酰胺轴保护小鼠免受胆碱缺乏高脂饮食诱导的代谢功能障碍相关脂肪性肝病的影响
Min Ji Kim,You Ri Park,Gibong Jang et al.
Min Ji Kim et al.
Aim: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major cause of chronic liver disease, yet its pathogenesis remains incompletely understood. Oxidative stress is thought to play a key role in MASLD progression. This...
High Incidence of Lethal Ventricular Arrhythmia-Sudden Cardiac Death in Early Myocardial Ischemia: Critical Roles of Cross-Regulation Between Stresses and Calcium Imbalance [0.03%]
早期心肌缺血致命性室性心律失常及心脏猝死的高发生率：应力与钙稳态失调交互作用的关键作用
Xiaojuan Zhang,Mengxuan Zhang,Ye Zhang et al.
Xiaojuan Zhang et al.
Aims: Early myocardial ischemia (MI) predisposes to lethal ventricular arrhythmias (LVA) and subsequent sudden cardiac death (SCD). This study aims to elucidate the roles of cross-regulation between oxidative stress, endoplasmic reticulum (...