GRX2-Mediated Deglutathionylation of SIRT3 Alleviates Intestinal Ischemia/Reperfusion-Induced Mitochondrial Oxidative Damage [0.03%]
GRX2介导的SIRT3脱谷氨酰胺化减轻肠道缺血/再灌注诱导的线粒体氧化损伤
Liangyuan Yin,Zhecheng Wang,Xuzi Zhao et al.
Liangyuan Yin et al.
Aims: Mitochondrial oxidative damage is one of the factors that contributes to the pathological process of intestinal ischemia/reperfusion (II/R) injury. Glutaredoxin (GRX2), which serves as a crucial protein in maintaini...
Dual Regulation of ACSL3 by TRIM33-Mediated Ubiquitination and NBR1-Dependent Autophagy: A Therapeutic Target for Cerebral Ischemia-Reperfusion Injury [0.03%]
由TRIM33介导的泛素化和NBR1依赖性自噬双重调控ACSL3：治疗脑缺血再灌注损伤的新靶点
Yueqing Yang,Ming Zhao,Yibo Feng et al.
Yueqing Yang et al.
Background: Cerebral ischemia-reperfusion injury (CIRI) is a key contributor to stroke-related neurological damage, but the functional interplay between autophagy and ferroptosis-two critical pathological processes-remain...
Selenium-Binding Protein 1 Deficiency Inhibits the Antitumor Immunity of Dendritic Cells [0.03%]
硒结合蛋白1缺乏抑制树突状细胞的抗肿瘤免疫作用
Shuang Han,Yi Li,Jie Meng et al.
Shuang Han et al.
Aims: Selenium-binding protein 1 (SELENBP1) correlates positively with the prognosis of patients with colitis and colon cancer. SELENBP1-deficient dendritic cells (DCs) promote regulatory T cell differentiation and exert ...
Targeted Restoration of Mitophagy Reinvigorates Aged Hematopoietic Stem Cells [0.03%]
线粒体自噬通路的激活可改善造血干细胞功能衰退现象
Jin Liu,Aiwei Wu,Jieyu Ling et al.
Jin Liu et al.
Aims: Aging-related functional decline in hematopoietic stem cells (HSCs) is closely associated with mitochondrial dysfunction and impaired mitophagy. This study aimed to investigate whether targeted restoration of mitoph...
Mannose Ameliorates Radiation-Induced Intestinal Injury in Mice via Preventing Mitochondrial Dysfunction [0.03%]
岩藻糖通过防止线粒体功能障碍来改善小鼠放射诱导的肠道损伤
Yanqing Liu,Renjun Peng,Yiying Zhang et al.
Yanqing Liu et al.
Aims: Radiation-induced intestinal injury (RIII) severely compromises the quality of life in patients undergoing abdominal/pelvic radiotherapy and may necessitate treatment discontinuation. To date, there is no approved a...
BACH2 Exacerbates Bronchopulmonary Dysplasia by Promoting NCOA4-Dependent Ferritinophagy via Transcriptional Activation of JUN [0.03%]
BACH2通过转录激活JUN促进NCOA4依赖性铁蛋白自噬从而加重支气管肺发育不良
Menghua Zhao,Yizhong Wu,Bufei Wu et al.
Menghua Zhao et al.
Aims: This study investigated whether BACH2 affects bronchopulmonary dysplasia (BPD) through ferritinophagy and elucidated its molecular mechanisms. Resul...
A Unified Model of Cardiovascular Injury: How PANoptosis Connects Atherosclerotic Inflammation to Myocardial Death [0.03%]
心血管损伤的统一模型：PANoptosis如何将动脉粥样硬化性炎症与心肌细胞死亡联系起来
Xin Zhang,Mengdan Liu,Yunyun Yang et al.
Xin Zhang et al.
Significance: Cardiovascular disease is traditionally viewed through fragmented lenses-atherosclerosis, ischemia-reperfusion injury, and heart failure as distinct entities. Emerging evidence positions PANoptosis, an integ...
Reactive Oxygen and Reactive Nitrogen Species in Herpesvirus Infections: Mechanisms, Clinical Implications, and Therapeutic Opportunities [0.03%]
疱疹病毒感染中的活性氧和活性氮：机制、临床意义及治疗机会
Rodrigo Reyes-Ramírez,Areli J Navarro,Gerardo E Ortiz et al.
Rodrigo Reyes-Ramírez et al.
Significance: Herpesvirus infections are highly prevalent in the human population, causing a broad spectrum of diseases ranging from mild to severe that affect numerous tissues, although most infections remain asymptomati...
A Glucocorticoid-KLF9-CHCHD10 Axis Governs Mitochondrial Resilience in Radiation-Induced Lung Injury [0.03%]
糖皮质激素-KLF9-CHCHD10轴调控放射性肺损伤中的线粒体韧性
Peixin Tan,Kunpeng Wu,Mengsi Liu et al.
Peixin Tan et al.
Background: Radiation-induced lung injury (RILI) is a major dose-limiting complication of thoracic radiotherapy. Although mitochondrial damage has been implicated in RILI, the endogenous transcriptional programs that rest...
Unlocking Sulforaphane's Potential in Friedreich Ataxia: Further Evidence from Preclinical Investigations Using Induced Pluripotent Stem Cell-Derived Sensory Neurons [0.03%]
诱导多能干细胞来源的感觉神经元的临床前研究进一步证实了萝卜硫素治疗弗里德reich共济失调的潜力
Wenyao Yang,Bruce Thompson,Sara Miellet et al.
Wenyao Yang et al.
Aims: Friedreich ataxia (FRDA) is a neurodegenerative disorder typically caused by autosomal recessive inheritance of expanded guanine-adenine-adenine (GAA) repeats (>56) in both alleles of the frataxin (FXN) gene, leadin...