Polypeptide Nanomicrospheres Delivering Dexmedetomidine Mitigate Intestinal Ischemia/Reperfusion Injury by Regulating Autophagy and Inflammation [0.03%]
载有右美托咪定的多肽纳微球通过调节自噬和炎症减轻肠缺血再灌注损伤
Zhen Liu,Qian Hu,Qiuhong Chen et al.
Zhen Liu et al.
Aims: This study aims to evaluate the protective effects of dexmedetomidine-loaded polypeptide nanomicrospheres (PNM@Dex) in a mouse model of intestinal ischemia/reperfusion (I/R) injury and investigate the underlying molecular mechanisms, ...
Retinoic Acid Receptor-related Orphan Receptor α Drives Glucose Reprogramming and Mitochondrial Rescue Mitigate Subarachnoid Hemorrhage-Induced Early Brain Injury [0.03%]
视黄酸受体相关孤儿受体α驱动葡萄糖代谢重编程及线粒体功能恢复减轻动脉瘤性蛛网膜下腔出血后早期脑损伤
Jie Li,Jiaqi Wang,Sijing Guo et al.
Jie Li et al.
Aims: Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular event characterized by early brain injury (EBI) within 72 h that is driven by oxidative stress, mitochondrial dysfunction, and metabolic collapse. The retinoic acid recept...
D-Allulose Regulates Obesity via Endoplasmic Reticulum Stress-Mediated Glucagon-Like Peptide-1 Receptor Pathway [0.03%]
D-阿洛糖通过内质网应激介导的胰高血糖素样肽-1受体通路调节肥胖症
Geum-Hwa Lee,Hwa-Young Lee,Young Jae Lim et al.
Geum-Hwa Lee et al.
Aims: Obesity remains a major global health issue, with the increasing focus on the incretin hormone glucagon-like peptide-1 (GLP-1) and its receptor (GLP-1R) for therapeutic strategies. D-allulose is predicted to modulate GLP-1R via mechan...
THRA Orchestrates Myocardial Protection Against Hypothyroidism-Induced Ferroptosis via the GATA4-GPX4 Transcriptional Cascade [0.03%]
甲状腺功能减退诱发的心肌细胞铁死亡的转录调控机制研究
Zhang Runfang,Xianen Fa
Zhang Runfang
Aims: Hypothyroidism frequently causes myocardial injury, but the role of thyroid hormone receptor alpha (THRA) remains unclear. This study investigated the function and mechanism of THRA in hypothyroidism-associated cardiac damage. Methods...
Dose-Dependent Ferroptosis Induction in Osteosarcoma via NRF2/GPX4 Axis Modulation by Plasma-Activated Liquid Therapy [0.03%]
等剂量依赖性血浆活化液体疗法通过调节NRF2 / GPX4轴诱导成骨肉瘤铁死亡
Longze Xiao,Mian Zhang,Peng He et al.
Longze Xiao et al.
Aims: Plasma-activated liquid (PAL), an indirect application form of cold-atmospheric plasma (CAP)-an ionized gas generating reactive oxygen and nitrogen species, has been proposed as an innovative therapeutic approach for various cancer ty...
Ferroptosis in Tubular Epithelial Cells Across Distinct Renal Regions Is a Primary Causal Factor for Lupus Nephritis [0.03%]
狼疮性肾炎的病因是不同肾脏区域的管状上皮细胞铁死亡所致
Wumeng Jin,Hualing Chen,Shuanglin Zhang et al.
Wumeng Jin et al.
Aims: Ferroptosis has been implicated in the pathogenesis of lupus nephritis (LN), yet its precise role and mechanisms remain unclear. This study aimed to clarify the role of ferroptosis in LN progression and its underlying mechanisms. Meth...
PGK1 Persulfidation Promotes the Proliferation and Metastasis of Breast Cancer [0.03%]
蛋白质PGK1的硫醇基化促进乳腺癌细胞增殖和转移
Chenghua Luo,Mengmeng Zhao,Yalu Wang et al.
Chenghua Luo et al.
Aims: Endogenous hydrogen sulfide (H2S) is involved in the occurrence and development of breast cancer, while its underlying mechanism is not yet clear. Here, we aimed to focus on the molecular mechanism of endogenous H2S promoting the prol...
m6A-Dependent Upregulation of PFKFB3 Drives Macrophage-Mediated Inflammation in Necrotizing Enterocolitis [0.03%]
M6A依赖的PFKFB3上调驱动坏死性小肠结肠炎中的巨噬细胞介导炎症反应
Chaoting Lan,Bowen Tian,Yingyan Liu et al.
Chaoting Lan et al.
Aims: This study aimed to elucidate the role of N6-methyladenosine (m6A) methylation in necrotizing enterocolitis (NEC) pathogenesis, focusing on its regulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) expression, ...
SQSTM1/p62 Post-Translational Modifications and Reverse Processes Modulate Disease Pathogenesis via KEAP1-NRF2 Signaling and Selective Autophagy [0.03%]
SQSTM1/p62 的翻译后修饰及逆向过程通过KEAP1-NRF2信号传导和选择性自噬调节疾病发生发展
Dongrong Zhu,Yue Li,Lirong Zhao et al.
Dongrong Zhu et al.
Significance: Sequestosome 1 (SQSTM1/p62, hereafter referred to as p62) is a multifunctional ubiquitin-binding autophagy receptor that acts as a critical bridge between the kelch-like ECH-associated protein 1 and nuclear factor erythroid 2-...
Intestinal Bacterium Akkermansia muciniphila Inhibits Progression of Abdominal Aortic Aneurysm [0.03%]
肠道细菌Akkermansia muciniphila可抑制腹主动脉瘤进展
Xin He,Yu Liu,Haiyang Zhou et al.
Xin He et al.
Aims: This study aimed to investigate the potential molecular mechanisms of Akkermansia muciniphila (Akk) in the treatment of abdominal aortic aneurysm (AAA) through the use of 16S rRNA sequencing and transcriptome sequencing technologies. ...