BACH2 Exacerbates Bronchopulmonary Dysplasia by Promoting NCOA4-Dependent Ferritinophagy via Transcriptional Activation of JUN [0.03%]
BACH2通过转录激活JUN促进NCOA4依赖性铁蛋白自噬从而加重支气管肺发育不良
Menghua Zhao,Yizhong Wu,Bufei Wu et al.
Menghua Zhao et al.
Aims: This study investigated whether BACH2 affects bronchopulmonary dysplasia (BPD) through ferritinophagy and elucidated its molecular mechanisms. Resul...
A Unified Model of Cardiovascular Injury: How PANoptosis Connects Atherosclerotic Inflammation to Myocardial Death [0.03%]
心血管损伤的统一模型：PANoptosis如何将动脉粥样硬化性炎症与心肌细胞死亡联系起来
Xin Zhang,Mengdan Liu,Yunyun Yang et al.
Xin Zhang et al.
Significance: Cardiovascular disease is traditionally viewed through fragmented lenses-atherosclerosis, ischemia-reperfusion injury, and heart failure as distinct entities. Emerging evidence positions PANoptosis, an integ...
Reactive Oxygen and Reactive Nitrogen Species in Herpesvirus Infections: Mechanisms, Clinical Implications, and Therapeutic Opportunities [0.03%]
疱疹病毒感染中的活性氧和活性氮：机制、临床意义及治疗机会
Rodrigo Reyes-Ramírez,Areli J Navarro,Gerardo E Ortiz et al.
Rodrigo Reyes-Ramírez et al.
Significance: Herpesvirus infections are highly prevalent in the human population, causing a broad spectrum of diseases ranging from mild to severe that affect numerous tissues, although most infections remain asymptomati...
A Glucocorticoid-KLF9-CHCHD10 Axis Governs Mitochondrial Resilience in Radiation-Induced Lung Injury [0.03%]
糖皮质激素-KLF9-CHCHD10轴调控放射性肺损伤中的线粒体韧性
Peixin Tan,Kunpeng Wu,Mengsi Liu et al.
Peixin Tan et al.
Background: Radiation-induced lung injury (RILI) is a major dose-limiting complication of thoracic radiotherapy. Although mitochondrial damage has been implicated in RILI, the endogenous transcriptional programs that rest...
Unlocking Sulforaphane's Potential in Friedreich Ataxia: Further Evidence from Preclinical Investigations Using Induced Pluripotent Stem Cell-Derived Sensory Neurons [0.03%]
诱导多能干细胞来源的感觉神经元的临床前研究进一步证实了萝卜硫素治疗弗里德reich共济失调的潜力
Wenyao Yang,Bruce Thompson,Sara Miellet et al.
Wenyao Yang et al.
Aims: Friedreich ataxia (FRDA) is a neurodegenerative disorder typically caused by autosomal recessive inheritance of expanded guanine-adenine-adenine (GAA) repeats (>56) in both alleles of the frataxin (FXN) gene, leadin...
Itaconate Ameliorates Skin Fibrosis Through Inhibition of HIF-1α/LDHA-Driven Aerobic Glycolysis [0.03%]
衣康酸通过抑制HIF-1α/LDHA介导的糖酵解缓解皮肤纤维化
Linxiao Li,Xiaohui Miao,Yu Cheng et al.
Linxiao Li et al.
Background: Skin fibrosis is a hallmark of scleroderma and other fibrotic skin disorders, yet effective therapies remain limited. Immune-derived metabolites have emerged as regulators of inflammation and tissue remodeling...
From Metabolic Memory to Ferroptotic Susceptibility: A Critical Review of Epigenetic Regulation and Ferroptosis in Diabetic Complications [0.03%]
从代谢记忆到铁死亡敏感性：糖尿病并发症中铁死亡表观遗传调控的研究进展及思考
Hongjuan Fang,Qiang Wang
Hongjuan Fang
Background: The clinical phenomenon of metabolic memory, in which diabetic complications may progress despite later glycemic improvement, lacks a complete explanation. Persistent oxidative stress, advanced glycation, mito...
Inflammation Impairs Poststroke Recovery by Disrupting Iron Homeostasis in Brain [0.03%]
脑炎通过破坏大脑中铁的稳态从而影响中风恢复
Xin Guo,Xiaofang Jin,Shaomeng Kang et al.
Xin Guo et al.
Aim: The activation of microglia triggers an inflammatory response, which is frequently associated with an imbalance of iron metabolism. This study aimed to determine whether inflammation-associated iron dyshomeostasis co...
Histone Lactylation Links Glycolysis to Ferroptosis in Diabetic Cataract [0.03%]
组蛋白乳酰化连接糖酵解与糖尿病白内障铁死亡
Dan Tao,He Wang,Zeyuan Liu et al.
Dan Tao et al.
Aims: This study aimed to delineate a novel mechanistic axis linking hyperglycemia-driven glycolytic reprogramming to ferroptotic death in lens epithelial cells (LECs) and to determine its therapeutic significance in diab...
Insights into the Multifaceted Roles of 3-Mercaptopyruvate Sulfurtransferase in Liver Diseases [0.03%]
3-硫解酶在肝病中的作用机制研究进展
Yirong Xia,Meng Li
Yirong Xia
Significance: Hydrogen sulfide (H2S), a vital gasotransmitter in liver physiology and pathology, is produced by cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (MPST...