CXCR 4, PAX5, and OCT2 Immunohistochemical Expressions in Diffuse Large B-Cell Lymphoma and Their Relationship with XIST/miR-34/PAX5 Axis [0.03%]
CXCR4、PAX5和OCT2在弥漫大B细胞淋巴瘤中的免疫组化表达及其与XIST/miR-34/PAX5轴的关系
Noha F Elaidy,Samia Hussein,Hoda F Ebian et al.
Noha F Elaidy et al.
C-X-C chemokine receptor 4 (CXCR4) is a chemokine receptor. Paired box protein 5 (PAX5) is a nuclear transcription factor. Octamer-binding protein 2 (OCT2) is a B-cell-restricted transcription factor. This study aimed to evaluate the protei...
Lnc- HSFY2-10:1 Contributes to Keratinocyte Proliferation and Psoriatic Inflammation Through miR-145-5p/FN1 Axis [0.03%]
长链非编码RNA Lnc-HSFY2-10：1通过miR-145-5p/FN1轴促进角质形成细胞增殖和银屑病炎症反应
Luan Yang,Ruijie Wang,Yingying Sun et al.
Luan Yang et al.
Psoriasis is an immune-mediated chronic inflammatory disease characterized by keratinocyte hyperproliferation and inflammatory cell infiltration. While noncoding RNAs are implicated in its progression, research remains limited. Integrating ...
Hirudin Inhibits Pyroptosis to Alleviate Renal Fibrosis via the mTOR/HIF-1α Pathway [0.03%]
肝素辅因子Ⅱ抑制肾纤维化介导的pyroptosis作用机制研究
Chunli Long,Jiefang Chen,Yongxiang Xie
Chunli Long
Hirudin, a polypeptide extracted from medicinal leeches, has demonstrated potential in treating renal fibrosis. This study aimed to explore the underlying mechanisms by which Hirudin alleviates renal fibrosis. Renal fibrosis models were est...
Genomic Landscape of Non-Squamous Non-Small Cell Lung Cancer in a Southern Brazilian Population: High PDL-1 Expression and Enrichment of EGFR and TP53 Mutations [0.03%]
南巴西非鳞状非小细胞肺癌的基因组特征：高PDL-1表达和EGFR及TP53突变富集
Gabriel Lima Lopes,Gilberto de Castro Junior,Marla Karine Amarante et al.
Gabriel Lima Lopes et al.
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths worldwide. The genomic database for NSCLC is expanding rapidly, highlighting the importance of characterizing subpopulations from diverse regions. This...
IL-33 Has a Protective Effect Against Perinatal Listeriosis by Regulating Mitophagy of CD8+ T Lymphocytes [0.03%]
IL-33通过调节CD8+T淋巴细胞的线粒体自噬对围产期李斯特菌感染具有保护作用
Tingjuan Shi,Yuxi Yang,Yingying Li et al.
Tingjuan Shi et al.
Listeriosis is a foodborne disease caused by Listeria monocytogenes (Lm) that usually leads to serious adverse outcomes in pregnant women. Interleukin (IL)-33/serum stimulation (ST)2 axis has an important impact on infectious diseases, but ...
CXCL13 as a Predictive Biomarker for Response to Methotrexate Monotherapy in Rheumatoid Arthritis [0.03%]
CXCL13作为预测类风湿性关节炎单用甲氨蝶呤治疗反应的生物标志物
Vishnu S Chandran,Mithun C B,Sajitha Krishnan et al.
Vishnu S Chandran et al.
This prospective study investigated the utility of baseline CXCL13 levels in predicting methotrexate response and monitoring disease activity in 50 treatment-naive early rheumatoid arthritis (RA) patients (2010 American College of Rheumatol...
Inhibition of FKBP5 Alleviates Inflammation and Intestinal Barrier Dysfunction in Sepsis [0.03%]
FKBP5抑制缓解脓毒症中的炎症和肠道屏障功能障碍
Jian Li,Anwaier Apizi,Tingting Song et al.
Jian Li et al.
Background: The pro-apoptotic and pro-inflammatory effects of FK506 binding protein 5 (FKBP5) in sepsis-induced acute kidney injury have been previously reported. However, its biological functions and underlying mechanisms in regulating sep...
Differential Expression of Th17-Related Cytokines in Patients of Chronic Kidney Disease with and Without Systemic Lupus Erythematosus [0.03%]
系统性红斑狼疮与非系统性红斑狼疮慢性肾脏病患者Th17相关细胞因子的差异表达
Farhad Seif,Karrar Hadi Kadhim,Milad Ahmadaghdami et al.
Farhad Seif et al.
Dysregulation of immune cells and cytokines, particularly T helper 17 (Th17) cells and their associated cytokines, is implicated in the pathogenesis of both systemic lupus erythematosus (SLE) and chronic kidney disease (CKD). This study aim...
Significant Associations Between Blood Cell Counts and a Large Number of Salivary Cytokines, Chemokines, and Growth Factors [0.03%]
血液细胞计数与大量唾液细胞因子、趋化因子和生长因子存在显著相关性
Lars B Eriksson,Mats Eriksson,Torsten Gordh et al.
Lars B Eriksson et al.
The association between local oral inflammation and cardiovascular risk has been extensively studied, with results indicating a bidirectional relationship. The aim of the present study was to investigate the associations between blood cells...
Epigenome-Wide DNA Methylation Profiling of Peripheral Blood Shows Lymphocyte Dysfunction in Children with Kawasaki Disease [0.03%]
儿童川崎病外周血表观基因组范围内的DNA甲基化检测显示淋巴细胞功能障碍
Jayakanthan Kabeerdoss,Rakesh Kumar Pilania,Taru Goyal et al.
Jayakanthan Kabeerdoss et al.
Kawasaki disease (KD) is an acute childhood vasculitis, commonly seen in children under the age of five. Despite extensive research over the past five decades, the pathogenesis of KD remains elusive. The objective of this epigenetic reanaly...