A Distinct c-Raf-MEK1/2-p38 MAPK-Caspase Signaling Pathway Mediates TNF-α-Induced Rapid and Non-Lytic Neutrophil Extracellular Trap Formation in Human Neutrophil-Like Cells [0.03%]
人中性粒细胞样细胞中TNF-α诱导的非溶性NETs形成由一种独特的c-Raf-MEK1/2-p38 MAPK-半胱天冬酶信号通路介导
Sung-Hun Woo,Yerang Lee,Sung Hoon Kim et al.
Sung-Hun Woo et al.
Neutrophil extracellular traps (NETs) contribute to host defense by trapping pathogens. However, excessive or dysregulated NET formation is implicated in the pathogenesis of various conditions, including thrombosis, autoimmune diseases, and...
Suppression of Lipopolysaccharide-Induced Cytokine Production by Chemokine Ligand-1 Short Hairpin RNA [0.03%]
化学引物-1短发夹核糖核酸抑制脂多糖诱导的细胞因子产生
Thuraya Elgreu,Serge Dibart,Xiaoren Tang
Thuraya Elgreu
Objectives: Lipopolysaccharide (LPS) from oral Gram-negative bacteria induces inflammatory responses involving the chemokine CXCL1. Although CXCL1 is known to mediate inflammation, its role in disease processes remains incompletely understo...
Low Gut Bifidobacterium Relative Abundance and Low Intake of Zinc, Omega-3 Fatty Acids, and Vitamin D Are Associated With Inflammation in Children [0.03%]
肠道乳酸杆菌相对含量低及锌、欧米伽-3脂肪酸和维生素D摄入量低与儿童炎症相关
Cinthia Denisse Pérez-Carrillo,Juan Carlos Ayala-García,Cinthya Estefhany Díaz-Benítez et al.
Cinthia Denisse Pérez-Carrillo et al.
Maintaining optimal health in childhood is essential for proper physical, motor, and neurological development. A balanced gut microbiota and adequate micronutrient intake support immune regulation, preservation of the intestinal barrier, an...
Tumor Necrosis Factor: A Master Regulator in Inflammation and Disease-Pathways, Implications, and Breakthrough Therapies [0.03%]
肿瘤坏死因子：炎症和疾病中的主要调节因子-途径、影响及突破性疗法
Simhadri Goud Gundrathi,Bharat Kumar Reddy Sanapalli,Ashwini Deshpande et al.
Simhadri Goud Gundrathi et al.
Tumor necrosis factor-alpha (TNF-α), a crucial proinflammatory cytokine, is involved in immune regulation and in the pathogenesis of a variety of chronic inflammatory and autoimmune diseases. TNF-α signaling dysregulation is linked to chr...
Identification of Inflammasome-Related Genes and Their Role in Predicting Community-Acquired Pneumonia [0.03%]
炎症小体相关基因的鉴定及其在社区获得性肺炎预后预测中的作用
Jia Zhao,Li Liu,Chaoli Zhou et al.
Jia Zhao et al.
Community-acquired pneumonia (CAP) is a common respiratory infectious disease worldwide, posing a significant threat to human health. In recent years, the crucial role of inflammasomes in the occurrence and development of pneumonia has grad...
Potential Gastric Cancer Biomarker in Gastric Juice: Adenosine and Its Role in the Immune Evasion Mechanism of Gastric Cancer [0.03%]
胃癌生物标志物——胃液腺苷及其在胃癌免疫逃逸机制中的作用
Yunhai Wei,Huancen Guo,Wenjing Hu et al.
Yunhai Wei et al.
Adenosine, a common cellular metabolite, can remodel the tumor immune microenvironment. Although gastric juice is considered a potential biomarker for gastric cancer (GC), sufficient verification is still lacking. This study aims to explore...
IRF1-Regulated CCL25/CCR9 Promotes Chronic Kidney Disease Progression Through PI3K/AKT-Mediated Oxidative Stress and Inflammatory Response [0.03%]
IRF1通过PI3K/AKT介导的氧化应激和炎症反应调节CCL25/CCR9促进慢性肾脏病进展
Shaorong Yan,Yueping Chen,Hong Liang Chen et al.
Shaorong Yan et al.
Chronic kidney disease (CKD) is imperceptible and with a complex pathogenesis involving oxidative stress and inflammatory responses. The phosphatidylinositol 3 kinases/protein kinase B (PI3K/AKT) signaling pathway plays a crucial role in th...
Zika Virus Human Infection During Pregnancy Triggers a Strong and Broad Systemic Inflammatory Response [0.03%]
寨卡病毒感染孕妇可引起强烈的全身性炎症反应
Andréa Teixeira-Carvalho,Lis Ribeiro do Valle Antonelli,Gemilson Soares Pontes et al.
Andréa Teixeira-Carvalho et al.
Infection by the Zika virus (ZIKV) results in a broad spectrum of disease ranging from mild to severe neurological complications. The clinical features of ZIKV human infection are similar in pregnant women compared with nonpregnant women, t...
Targeting MDA5-Mediated Interferon Responses in Type 1 Diabetes: Structural Insights, Mechanism, and Potential Therapeutic Approaches [0.03%]
针对1型糖尿病中MDA5介导的I型干扰素反应：结构洞察、机制及潜在治疗策略
Opeoluwa F Iwaloye,Clayton E Mathews,Danmeng Li
Opeoluwa F Iwaloye
Melanoma differentiation-associated protein 5 (MDA5), encoded by IFIH1, is a cytosolic double-stranded RNA (dsRNA) sensor. Mutation of IFIH1 resulting in MDA5 deficiency causes immune dysfunction and predisposition to specific respiratory v...
Targeted Inhibition of RPA3 Impairs Breast Cancer Progression Through Suppressing TGF-β Signaling Pathway-Mediated Autophagy [0.03%]
靶向抑制RPA3通过抑制TGF-β信号通路介导的自噬来阻碍乳腺癌进展
Zhiyi Zhang,Haipeng Yu,Liqun Hao
Zhiyi Zhang
As a key component of the replication protein A (RPA) complex, RPA3 has been identified as oncogenic in multiple solid tumors. However, its specific role in breast cancer remains poorly understood. RPA3 expression and its prognostic relevan...