Diagnostic Performance of Biomarkers Tumor Necrosis Factor-α, Interleukin-6, and Procalcitonin in Neonatal Sepsis: A Case-Control Study [0.03%]
肿瘤坏死因子-α、白细胞介素-6和降钙素原在新生儿败血症中的诊断效能：一项病例对照研究
Durgesh Kumar,Dinesh Kumar,Nishant Sharma et al.
Durgesh Kumar et al.
Neonatal sepsis remains a major cause of morbidity and mortality, with diagnosis complicated by nonspecific clinical signs and limited reliability of conventional laboratory tests. This study aimed to evaluate and compare the diagnostic eff...
Transforming Growth Factor-beta 1 Alleviates Uterine Bleeding after Medication Abortion in Early Pregnancy by Upregulating the p53/Plasminogen Activator Inhibitor-1 Pathway [0.03%]
转化生长因子β1通过上调p53/纤溶酶原激活物抑制物-1途径缓解药物流产后的早期妊娠子宫出血
Qianhong Huang,Haiying Lan,Hao Yu et al.
Qianhong Huang et al.
TGF-β1 plays a significant role in pregnancy outcomes. This research sought to investigate whether TGF-β1 is involved in the bleeding mechanism after medication abortion (MA) in early pregnancy. The MA rat model was established in vivo us...
Exosomes Derived from Platelet-Rich Plasma Facilitates Macrophage Mitophagy in Diabetic Wound Healing by Targeting KNG1 via PI3K-AKT Pathway [0.03%]
富血小板血浆衍生的外泌体通过PI3K-Akt途径靶向KNG1促进糖尿病创面修复中巨噬细胞线粒体自噬作用
Cao Han,Tao Zhong,Zhengnan Zhao et al.
Cao Han et al.
This study was conducted to investigate the protective effect of platelet-rich plasma-derived exosomes (PRP-Exos) in diabetic wound healing, as well as the involved molecular mechanism. Exosomes collected from PRP were extracted and identif...
Liquid-Liquid Phase Separation-Related STAT1 Modulating Ubiquitination Aggravates the Progression of Diabetic Nephropathy via Promoting Inflammatory Response [0.03%]
液滴凝聚相关STAT1泛素化修饰通过促进炎症反应加重糖尿病肾病进展
Song Xue,Yingkui Si,Xue Han
Song Xue
This study aims to screen liquid-liquid phase separation (LLPS)-related genes modulating ubiquitination for diagnosing patients with diabetic nephropathy (DN). After performing differential gene expression analysis, ssGSEA, and immune infil...
Bushen Huoxue Acupuncture Suppresses the Release of Inflammation Cytokines in a Mouse Model of Neurodegenerative Disease by Modulating the SIRT2/RTN4B/BACE1 Pathway [0.03%]
补肾活血电针对神经退行性疾病模型小鼠炎症因子释放的调控作用及机制研究
Hongqin Li,Rong Xu,Liquan Xie et al.
Hongqin Li et al.
Bushen Huoxue Acupuncture shows potential in treating neurodegenerative diseases, but its mechanisms remain incompletely understood. Using the senescence-accelerated mouse-prone 8 (SAMP8) mouse model, we assessed cognitive function via the ...
Immunomodulatory Effects of Ticagrelor in Myocardial Infarction: Shifting the Cytokine Balance Toward an Anti-Inflammatory Profile [0.03%]
替格瑞洛在心肌梗死中的免疫调节作用：将细胞因子平衡向抗炎型转变
Delan Yaseen Sulaiman,Talar Ahmad Merza Mohammad
Delan Yaseen Sulaiman
Myocardial infarction (MI) triggers a systemic inflammatory response that influences cardiac recovery. Pharmacological therapies, including aspirin, β-blockers, ACE inhibitors, statins, and P2Y12 inhibitors such as Ticagrelor, may have add...
Severe Impairment of IFN-α and IFN-γ Responses in Cells of a Patient with a Rare STAT1 Tail Segment Domain Mutation [0.03%]
STAT1尾区结构突变患者I型干扰素应答受损
Jing Xiao,Jiapeng Qiu
Jing Xiao
Signal transducer and activator of transcription 1 (STAT1) mutations are associated with diverse pathologies. Loss-of-function (LOF) heterozygous mutations impair interferon (IFN) signaling, predisposing to Mendelian susceptibility to mycob...
CXCR 4, PAX5, and OCT2 Immunohistochemical Expressions in Diffuse Large B-Cell Lymphoma and Their Relationship with XIST/miR-34/PAX5 Axis [0.03%]
CXCR4、PAX5和OCT2在弥漫大B细胞淋巴瘤中的免疫组化表达及其与XIST/miR-34/PAX5轴的关系
Noha F Elaidy,Samia Hussein,Hoda F Ebian et al.
Noha F Elaidy et al.
C-X-C chemokine receptor 4 (CXCR4) is a chemokine receptor. Paired box protein 5 (PAX5) is a nuclear transcription factor. Octamer-binding protein 2 (OCT2) is a B-cell-restricted transcription factor. This study aimed to evaluate the protei...