miRNA-133a-5p Inhibits the Expression of Osteoblast Differentiation-Associated Markers by Targeting the 3' UTR of RUNX2 [0.03%]
微小核糖核酸133a通过作用于RUNX2的3'-UTR而抑制成骨细胞分化标记基因的表达
Wei Zhang,Yonggang Wu,Yasuyuki Shiozaki et al.
Wei Zhang et al.
Recent studies have recognized the involvement of microRNAs (miRNAs) in the development of osteoporosis, which regulate the balance between osteogenesis and osteoclasis. In this study, we investigated the regulation by miRNA-133a-5p on the ...
Melatonin Inhibits the Proliferation of Gastric Cancer Cells Through Regulating the miR-16-5p-Smad3 Pathway [0.03%]
褪黑素通过调节miR-16-5p-Smad3信号通路抑制胃癌细胞增殖
Chenyu Zhu,Qun Huang,Hongyu Zhu
Chenyu Zhu
The incidence and mortality of gastric cancer is steadily increasing annually around the world, which required further investigation about alternative therapy strategies. Melatonin, an indoleamine synthesized in the pineal gland, has shown ...
Correlation Between Single-Nucleotide Polymorphisms Within miR-30a and Related Target Genes and Risk or Prognosis of Nephrotic Syndrome [0.03%]
miR-30a内单核苷酸多态性及其靶基因与肾病综合征发病风险及预后的相关性研究
Ruiheng Yang,Hong Hong,Mengjun Wang et al.
Ruiheng Yang et al.
This study was aimed to figure out the association of single-nucleotide polymorphisms (SNPs) within miR-30a and its downstream molecules (i.e., Notch1, Snail1, p53, CD73, and TET1) with susceptibility to and prognosis of nephrotic syndrome ...
Insulin Treatment Cannot Promote Lipogenesis in Rat Fetal Lung in Gestational Diabetes Mellitus Because of Failure to Redress the Imbalance Among SREBP-1, SCAP, and INSIG-1 [0.03%]
妊娠糖尿病胰岛素治疗失败的原因是不能在大鼠肺组织中纠正SREBP-1、SCAP和INSIG-1的失衡关系导致不能促进脂质合成
Jinyan Li,Guanhua Qian,Xiaocui Zhong et al.
Jinyan Li et al.
Gestational diabetes mellitus (GDM) has a higher incidence of neonatal respiratory distress syndrome, and lipogenesis is required for the synthesis of pulmonary surfactants. The aim of this study was to determine the effect of insulin treat...
Pyruvate Kinase M2 Modulates the Glycolysis of Chondrocyte and Extracellular Matrix in Osteoarthritis [0.03%]
丙酮酸激酶M2在骨关节炎中调节软骨细胞糖酵解及细胞外基质合成中的作用研究
Xiaobo Yang,Weiping Chen,Xiang Zhao et al.
Xiaobo Yang et al.
Pyruvate kinase M2 (PKM2) has been wildly verified to modulate glycolysis in tumor cells. However, the role of PKM2 on the glycolysis of osteoarthritis (OA) chondrocytes is still unclear. In present study, we investigate the function of PKM...
Linya Wang,Jing-Hsiung James Ou
Linya Wang
Macroautophagy, hereafter autophagy, is a catabolic process that is important for maintaining cellular homeostasis. It can also be used by cells to remove intracellular microbial pathogens. However, the studies on hepatitis C virus (HCV) in...
Changes in Body Mass Index, Leptin, and Leptin Receptor Polymorphisms and Breast Cancer Risk [0.03%]
体质指数、瘦素及瘦素受体多态性的改变与乳腺癌风险的关系
Chun-Rong Liu,Qin Li,Can Hou et al.
Chun-Rong Liu et al.
Obesity is a strong risk factor for breast cancer. The polymorphisms of leptin (LEP) and leptin receptor (LEPR) may be associated with breast cancer by regulator of adipose tissue mass and tumor cell growth. A total of 794 cases and 805 mat...
Posttranscriptional Regulation of Human Antigen R by miR-133b Enhances Docetaxel Cytotoxicity Through the Inhibition of ATP-Binding Cassette Subfamily G Member 2 in Prostate Cancer Cells [0.03%]
人源性抗原R由miR-133b进行产后转录调控通过抑制ATP结合盒子G成员2在前列腺癌细胞中增强多西他赛的毒性
Hui Liu,Xiaolong Song,Junqing Hou et al.
Hui Liu et al.
Docetaxel (DTX)-based chemotherapy is a first-line therapy in patients with castration-resistant prostate cancer. However, development of DTX resistance remains a challenge in cancer treatment. miRNAs have been shown to be involved in drug ...
Glaucocalyxin A Attenuates the Activation of Hepatic Stellate Cells Through the TGF-β1/Smad Signaling Pathway [0.03%]
金丝桃苷通过TGF-β1/Smads信号途径抑制肝星状细胞活化
Zhichao Dong,Qi Gao,Hao Guo
Zhichao Dong
Glaucocalyxin A (GLA) is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx. A large number of studies have shown that GLA possesses important pharmacological activities, such as anti-inflammato...
Functional Defects of Regulatory T Cell Through Interleukin 10 Mediated Mechanism in the Induction of Gestational Diabetes Mellitus [0.03%]
通过介导妊娠糖尿病发病的细胞因子白细胞介素10探讨调节性T细胞功能异常
Yan Yang,Lixiu Liu,Beibei Liu et al.
Yan Yang et al.
Gestational diabetes mellitus (GDM) is a metabolic and low-grade inflammatory disease most commonly found in pregnant women with high body mass index and non-Caucasian ethnicities; however, not all women of high-risk groups develop GDM. We ...