Streptozotocin-Induced Autophagy Reduces Intracellular Insulin in Insulinoma INS-1E Cells [0.03%]
链球菌诱导的自噬减少胰岛素瘤INS-1E细胞内的胰岛素
Yeong-Min Yoo,Yung Chul Park
Yeong-Min Yoo
Streptozotocin (STZ), a glucose analog, induces diabetes in experimental animals by inducing preferential cytotoxicity in pancreatic beta cells. We investigated whether STZ reduced the production of intracellular insulin through autophagy i...
RNA/Protein Discordant Expression of Fndc5 in Central Nervous System Is Likely to Be Mediated Through microRNAs [0.03%]
中枢神经系统中Fndc5的RNA和蛋白质表达差异可能是通过microRNA介导的
Somayeh Tanhaei,Parvaneh Nikpour,Kamran Ghaedi et al.
Somayeh Tanhaei et al.
Fibronectin type III domain-containing 5 protein (Fndc5) is responsible for producing a secretory protein termed, "irisin." A modified expression of Fndc5 has been reported in different tissues during development, differentiation processes,...
Genetic Analyses Identified a SALL4 Gene Mutation Associated with Holt-Oram Syndrome [0.03%]
基因分析发现与Holt-Oram综合征相关的SALL4基因突变
Bojian Li,Sun Chen,Kun Sun et al.
Bojian Li et al.
Holt-Oram syndrome (HOS) is an autosomal dominant disorder, which is characterized by deformities of upper limbs and congenital heart defects. Alterations of TBX5 gene have been identified to be the leading cause of HOS, while some cases co...
Case Reports
DNA and cell biology. 2018 Apr;37(4):398-404. DOI:10.1089/dna.2017.4094 2018
Insights into Macrophage Autophagy in Latent Tuberculosis Infection: Role of Heat Shock Protein 16.3 [0.03%]
结核潜伏感染状态下巨噬细胞自噬作用的新见解：热休克蛋白16.3的作用机制
Caiqin Zhang,Li Yang,Ningning Zhao et al.
Caiqin Zhang et al.
Tuberculosis (TB) is a major bacterial infectious disease worldwide that is predominantly caused by Mycobacterium tuberculosis (Mtb). The comorbidity of multiple drug-resistant TB strains with HIV and diabetes is widespread. In the presence...
Expression Profiles of Six Atherosclerosis-Associated microRNAs That Cluster in Patients with Hyperhomocysteinemia: A Clinical Study [0.03%]
高同型半胱氨酸血症患者六种与动脉粥样硬化相关的微小核糖核酸表达谱的临床研究
Kejian Liu,Saiyare Xuekelati,Kang Zhou et al.
Kejian Liu et al.
The aim of this study is to discuss the hypothesis that expression of plasma atherosclerosis-associated microRNAs (miRNAs) in hyperhomocysteinemia (Hhcy) patients could predict the presence of atherosclerosis from different channels. Six pl...
Identification of the Functional Autophagy-Regulatory Domain in HCLS1-Associated Protein X-1 That Resists Against Oxidative Stress [0.03%]
HCLS1相关蛋白X-1抵抗氧化压力的鉴定功能自噬调节域
Ying-Lan Li,Wen-Feng Cai,Lei Wang et al.
Ying-Lan Li et al.
HCLS1 Associated Protein X-1 (HAX1) promotes cell survival through attenuation of the damaged signals from endoplasmic reticulum and mitochondria, which are known as prominent intracellular compartments for the autophagic process under stre...
Ectopic Expression of JcWRKY Confers Enhanced Resistance in Transgenic Tobacco Against Macrophomina phaseolina [0.03%]
菊花WRKY基因的异源表达可提高转基因烟草对串珠镰刀菌的抗性
Parinita Agarwal,Khantika Patel,Pradeep K Agarwal
Parinita Agarwal
Plants possess an innate immune system comprising of a complex network of closely regulated defense responses involving differential gene expression mediated by transcription factors (TFs). The WRKYs comprise of an important plant-specific ...
Ufmylation Is Activated in Vascular Remodeling and Lipopolysaccharide-Induced Endothelial Cell Injury [0.03%]
血管重塑和脂多糖诱导的内皮细胞损伤中泛素样修饰活化
Ming Su,Zhihong Yue,Hui Wang et al.
Ming Su et al.
Vascular remodeling is a key process leading to arterial stenosis. Ufmylation, a novel ubiquitin-like modification, was observed to be associated with many biological processes. However, whether ufmylation is involved in the regulation of v...
Electromagnetic Field Could Protect SH-SY5Y Cells Against Cisplatin Cytotoxicity, But Not MCF-7 Cells [0.03%]
电磁场可保护SH-SY5Y细胞免受顺铂毒性作用，但不能保护MCF-7细胞
Hamideh Mahmoudinasab,Mostafa Saadat
Hamideh Mahmoudinasab
Cisplatin [cis-dichlorodiammine platinum (II), CDDP], morphine (Mor), and electromagnetic field (EMF) induced oxidative stress. In this study, we tried to increase the cytotoxicity of CDDP in combination with Mor and/or EMF in MCF-7 and SH-...
ABCB1 1199G > A Polymorphism Impacts Transport Ability of P-gp-Mediated Antipsychotics [0.03%]
ABCB1 1199G>A多态性影响P-糖蛋白介导的抗精神病药物转运能力
Rong Wang,Xuan Sun,Yong-Shu Deng et al.
Rong Wang et al.
The alterations in P-glycoprotein (P-gp)-mediated transport of antipsychotics due to the ABCB1 1199G>A polymorphism were assessed in the current study. The ABCB1wt and ABCB11199A recombinant cell models were constructed to study the sensiti...