The Impact of FSHR Gene Polymorphisms Ala307Thr and Asn680Ser in the Endometriosis Development [0.03%]
FSHR基因多态性位点Ala307Thr和Asn680Ser与子宫内膜异位症发病的关系研究
Gustavo Mendonça André,Camila Martins Trevisan,Isabela Nacione Pedruzzi et al.
Gustavo Mendonça André et al.
Endometriosis is an estrogen-dependent inflammatory disease that affects a large number of women in reproductive age. Follicle-stimulating hormone (FSH) plays a role in steroidogenesis and acts through a transmembrane glycoprotein, FSH rece...
Tissue Expression Analysis and Characterization of Smad3 Promoter in Bovine Myoblasts and Preadipocytes [0.03%]
牛肌母细胞和前脂肪细胞中Smad3启动子的组织表达分析及特征研究
Le Zhang,Yue Ning,Peiwei Li et al.
Le Zhang et al.
The transforming growth factor-β (TGFβ) pathway plays many key roles in regulating numerous biological processes. In addition, the effects of TGFβ are mediated by the transcription factor Smad3. However, the regulation of Smad3 activity ...
Unlike Butylcycloheptylprodigiosin, Isolated Undecylprodigiosin from Streptomyces parvulus Is Not a MDR1 and BCRP Substrate in Multidrug-Resistant Cancers [0.03%]
与丁基环庚基原儿茶酸不同，从链霉菌中分离的十一烷基 prodigiosin 不是多药耐药癌症中的MDR1和BCRP底物
Seyed Abbas Mirzaei,Mansureh Safari Kavishahi,Zhila Keshavarz et al.
Seyed Abbas Mirzaei et al.
The search for new chemotherapeutics unaffected by efflux pumps would significantly increase life expectancy in patients with malignant cancers. In this study, butylcycloheptylprodigiosin and undecylprodigiosin were HPLC-purified and verifi...
TET2: A Novel Epigenetic Regulator and Potential Intervention Target for Atherosclerosis [0.03%]
TET2：动脉粥样硬化表观遗传调控新机制及干预靶点研究进展
Yami Liu,Wen Peng,Kai Qu et al.
Yami Liu et al.
Atherosclerosis is the underlying cause of cardio-cerebrovascular disease. However, the mechanisms of atherosclerosis are still unclear. The modification of DNA methylation has an important role in atherosclerosis development. As a member o...
Functional Evaluation of ZNF350 Missense Genetic Variants Associated with Breast Cancer Susceptibility [0.03%]
与乳腺癌易感性相关的ZNF350错义基因变异的功能评价
Nasha Zhang,Youhua Lu,Xijun Liu et al.
Nasha Zhang et al.
ZNF350, a BRCA1-interacting protein, could mediate BRCA1-induced sequence-specific transcriptional repression of several genes, including GADD45α. As a potential breast cancer susceptibility gene, single nucleotide polymorphisms (SNPs), es...
Long Noncoding RNA AK021443 Promotes Cell Proliferation and Migration by Regulating Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma Cells [0.03%]
长非编码RNA AK021443通过调节上皮间质转化促进肝癌细胞增殖和迁移
Jihong Yang,Jinghua Li,Bo Liu et al.
Jihong Yang et al.
Long noncoding RNAs (lncRNAs) were dysregulated in many kinds of cancers, including hepatocellular carcinoma (HCC). AK021443, as a novel lncRNA, was found to be upregulated in HCC, while its potential value and function are still unknown. T...
Arnold Park,Guoyan Zhao
Arnold Park
Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing pancreatic beta cells. Although environmental factors interplay with genetic susceptibility to promote immune dysregulation and disease, it remains un...
miR-92b-3p Promotes Colorectal Carcinoma Cell Proliferation, Invasion, and Migration by Inhibiting FBXW7 In Vitro and In Vivo [0.03%]
miR-92b-3p通过抑制FBXW7促进结直肠癌细胞增殖、侵袭和迁移（体外和体内研究）
Lei Gong,Mingyang Ren,Zhenbing Lv et al.
Lei Gong et al.
microRNA (miR)-92b is an oncogenic miRNA. F-box and WD-40 domain protein 7 (FBXW7/hCdc4) is a tumor suppressor and a target of miR-92b-3p. This study was designed to investigate the effect of miR-92b-3p on colorectal carcinoma (CRC) invasio...
Protein O-Glucosyltransferase 1 Expression Influences Formation of Differentiated Myotubes in C2C12 Cell Line [0.03%]
蛋白O-葡萄糖基转移酶1的表达影响C2C12细胞系分化肌管的形成
Mélanie Pélisse,Audrey Der Vartanian,Agnès Germot et al.
Mélanie Pélisse et al.
The protein O-glucosyltransferase 1 (Poglut1) links O-glucose to epidermal growth factor-like repeats harboring the C1XSX(P/A)C2 consensus sequence. Poglut1 is a ubiquitous endoplasmic reticulum-resident protein largely found in metazoans, ...
HMGA1 Mediated High-Glucose-Induced Vascular Smooth Muscle Cell Proliferation in Diabetes Mellitus: Association Between PI3K/Akt Signaling and HMGA1 Expression [0.03%]
高血糖诱导的糖尿病血管平滑肌细胞增殖及其分子机制研究PI3K/Akt信号通路与HMGA1表达的关系
Qinghai Zhang,Ling Chen,Zhibo Zhao et al.
Qinghai Zhang et al.
High-mobility group protein A1 (HMGA1), an architectural transcription factor, was found to regulate multiple gene expression in mammals. Recent studies firmly indicate an association between HMGA1 and type 2 diabetes. However, the presence...