Long Noncoding RNA GAS5 Suppresses 3T3-L1 Cells Adipogenesis Through miR-21a-5p/PTEN Signal Pathway [0.03%]
长链非编码RNA GAS5通过miR-21-5p/PTEN信号途径抑制3T3-L1细胞分化诱导的脂质积累作用机制研究
Haifeng Liu,Huan Li,Long Jin et al.
Haifeng Liu et al.
Emerging studies indicated that both long noncoding RNAs and micro-RNAs play crucial roles in the mediation of adipogenesis, which is closely linked to obesity-related diseases. However, the mechanisms of lncRNA-miRNAs coregulating in adipo...
hsa_circ_0000177-miR-638-FZD7-Wnt Signaling Cascade Contributes to the Malignant Behaviors in Glioma [0.03%]
hsa_circ_0000177-miR-638-FZD7-Wnt信号通路促进胶质瘤的恶性行为
Zhiqiang Chen,Xingbang Duan
Zhiqiang Chen
As a new member of the noncoding RNA family, circular RNAs (circRNAs) have been demonstrated as critical regulators in various physiological and pathological processes, such as tumorigenesis. However, the role of circRNAs has not been well ...
The Association Between Vitamin D Binding Protein Polymorphisms and Vitamin D Level on Epilepsy in China [0.03%]
中国维生素D结合蛋白多态性与维生素D水平在癫痫中的相关性研究
Haidong Wang,Yujin Guo,Gongying Li et al.
Haidong Wang et al.
Accumulating studies suggest the potential association between epilepsy and vitamin D (VD) in recent years. Vitamin D binding protein (VDBP) is the main VD carrier and can affect the availability of VD and its metabolites. Thus, this study ...
Association Between Polymorphisms in CMTM Family Genes and Hepatocellular Carcinoma in Guangxi of China [0.03%]
广西CMTM家族基因多态性与肝细胞癌的关联分析
Chunhua Bei,Chao Tan,Xiaonian Zhu et al.
Chunhua Bei et al.
Polymorphisms in genes may affect its expression and alter individual susceptibility to cancer. In this study, we investigate associations between CMTM family gene polymorphisms and hepatocellular carcinoma (HCC) in a southern Chinese popul...
Selective Actionable and Druggable Protein Kinases Drive the Progression of Neuroendocrine Prostate Cancer [0.03%]
选择性作用于可操作且可药物化的蛋白激酶可以驱动神经内分泌前列腺癌的发展及进展
Chao Lu,Yunkai Qie,Shenglai Liu et al.
Chao Lu et al.
Current clinical anti-androgen therapies in advanced prostate cancer (PCa) are driving an increased incidence of neuroendocrine prostate cancer (NEPC), a histological variant exhibiting reduced androgen receptor levels and expression of neu...
A Comparative Study on Anti-Invasion, Antimigration, and Antiadhesion Effects of the Bioactive Carotenoids of Saffron on 4T1 Breast Cancer Cells Through Their Effects on Wnt/β-Catenin Pathway Genes [0.03%]
一种藏红花生物活性类胡萝卜素对4T1乳腺癌细胞抗入侵、抗迁移和抗黏附作用的比较研究及其对Wnt/β-连环蛋白途径基因的影响
Laleh Arzi,Gholamhossein Riazi,Majid Sadeghizadeh et al.
Laleh Arzi et al.
Crocus sativus L. (saffron) has been used as a spice and as a medicine for the past four thousand years. Recently, saffron has been well documented to possess anticancer effects on primary tumors. However studies of its antimetastatic poten...
Comparative Study
DNA and cell biology. 2018 Aug;37(8):697-707. DOI:10.1089/dna.2018.4248 2018
Resveratrol Reverts Epigenetic and Transcription Changes Caused by Smoke Inhalation on Bone-Related Genes in Rats [0.03%]
白藜芦醇逆转烟雾吸入引起的大鼠骨相关基因的表观遗传和转录改变
Aladim Gomes Lameira Jr,Beatriz Ganhito Françoso,Samir Absy et al.
Aladim Gomes Lameira Jr et al.
We investigated the effects of cigarette smoke (CS) and resveratrol intake on the modulation of bone repair-related genes through epigenetic mechanisms at the global and gene-specific levels, after 30 days of calvarial defects were created,...
The Combining Effects of Cell-Free Circulating Tumor DNA of Breast Tumor to the Noninvasive Prenatal Testing Results: A Simulating Investigation [0.03%]
无创产前基因检测受乳腺肿瘤释放的游离循环DNA影响的模拟研究
Ya-Hong Cai,Guang-Yu Yao,Lu-Jia Chen et al.
Ya-Hong Cai et al.
Massively parallel sequencing of circulating fetal DNA in the plasma of pregnant women is a common method for noninvasive prenatal testing (NIPT) of fetal trisomy 13, 18, and 21. However, circulating DNA is not restricted to pregnant women,...
Sertoli Cells Engineered to Express Insulin to Lower Blood Glucose in Diabetic Mice [0.03%]
表达胰岛素的曲细精管细胞降低糖尿病小鼠血糖水平
Gurvinder Kaur,Lea Ann Thompson,Rachel L Babcock et al.
Gurvinder Kaur et al.
Long-term survival of allo- and xenotransplanted immune-privileged Sertoli cells (SCs) is well documented suggesting that SCs can be used to deliver foreign proteins for cell-based gene therapy. The aim of this study was to use a lentivirus...
LrHMGB1 Shares Structural Similarities with Human HMGB1, and Its Expression Is Induced in Bacterial Infection, Antiviral Vaccination, and Pathogen-Associated Molecular Patterns Stimulation [0.03%]
LrHMGB1与人源HMGB1具有结构相似性，并且其表达可在细菌感染、抗病毒免疫接种以及病原相关分子刺激时被诱导上调
Saswati S Lenka,Mahismita Paichha,Madhubanti Basu et al.
Saswati S Lenka et al.
The high-mobility group box 1 (HMGB1) protein is a highly conserved nonhistone chromosomal protein ubiquitously present in almost all cell types. In the nucleus, it facilitates DNA repair and replication, V(D)J recombination, stabilization ...