Overexpression of Short Variant Form of New Kelch Family Protein Leads to Erythroid and Megakaryocyte Dysplasia by Targeting Megakaryocyte-Erythroid Progenitors [0.03%]
短型新Kelch家族蛋白过表达通过靶向巨核-红系祖细胞导致红系和巨核系发育异常
Yansi Lin,Yuxuan Luo,Fangxiao Hu et al.
Yansi Lin et al.
Nd1-S is the nuclear-localizing short variant form of Nd1 (Ivns1abp) encoding a Kelch family transcription factor. While the function of Nd1 has been investigated in the context of metastasis and doxorubicin-induced cardiotoxicity, little i...
Sudheer Gupta,Ankita Agarwal,Debasis Biswas
Sudheer Gupta
Dengue is a pandemic-prone viral disease which is endemic in more than 100 countries and which puts half of the world's population at risk. While the disease presents as subclinical infection or mild fever in the majority of cases, approxim...
Association Between Long Noncoding RNA MEG3 Polymorphisms and Lung Cancer Susceptibility in Chinese Northeast Population [0.03%]
MEG3长链非编码RNA多态性与东北汉族人肺癌易感性的关联研究
Zitai Yang,Hang Li,Juan Li et al.
Zitai Yang et al.
Long noncoding RNA (lncRNA) maternal-expressed gene 3 (MEG3) is associated with proliferation of various tumor cells and has decreased expression in many types of cancers. In this study, we aimed at demonstrating the association between MEG...
Identification of lncRNAs and Their Functional Network Associated with Chemoresistance in SW1990/GZ Pancreatic Cancer Cells by RNA Sequencing [0.03%]
通过RNA测序鉴定SW1990/GZ耐药性胰腺癌细胞中的长链非编码RNA及其功能网络
Duguang Li,Xiaowei Qian,Peng Xu et al.
Duguang Li et al.
Drug resistance is a major problem in the treatment of pancreatic cancer (PC). Long noncoding (lnc)RNAs modulate a variety of cellular processes. This study was carried out to identify lncRNAs that are differentially expressed in drug-resis...
Identification and Multilineage Potential Research of a Novel Type of Adipose-Derived Mesenchymal Stem Cells from Goose Inguinal Groove [0.03%]
家鹅腹股沟新类型脂肪源性间充质干细胞的鉴定及分化潜能研究
Caiyun Ma,Yu Guo,Hebao Wen et al.
Caiyun Ma et al.
Adipose tissue-derived mesenchymal stem cells (ADSCs) play a crucial role in the field of regenerative medicine and tissue repair for its own unique features. However, up to date, the isolation and characterizations of multidifferentiation ...
Construction, Expression, and Characterization of a Novel Human-Mouse Chimeric Antibody, Hm3A4: A Potential Therapeutic Agent for B and Myeloid Lineage Leukemias [0.03%]
新型人源化治疗B系和髓系白血病抗体Hm3A4的研究
Sisi Li,Diying Shen,Xiaoping Guo et al.
Sisi Li et al.
Antibody-targeting therapy has drawn great interests to the hematologists and oncologists. 3A4, a novel antibody recognizing human CD45RA antigen, is a new target molecule for leukemias and holds a therapeutic potential for myeloid lineage ...
LncRNA GAS5 Indel Genetic Polymorphism Contributes to Glioma Risk Through Interfering Binding of Transcriptional Factor TFAP2A [0.03%]
长链非编码RNA GAS5基因多态性通过干扰转录因子TFAP2A的结合参与胶质瘤发生发展的作用机制研究
Jupeng Yuan,Nasha Zhang,Yan Zheng et al.
Jupeng Yuan et al.
Long noncoding RNA (lncRNA) growth arrest-specific 5 (GAS5) accumulates in growth-arrested cells and plays a crucial role in progression of multiple cancers, including glioma. There is a functional GAS5 rs145204276 indel genetic polymorphis...
Human Adipose-Derived CD146+ Stem Cells Increase Life Span of a Muscular Dystrophy Mouse Model More Efficiently than Mesenchymal Stromal Cells [0.03%]
人CD146阳性脂肪来源干细胞比间充质基质细胞更高效地延长肌营养不良小鼠模型的寿命
Juliana P Gomes,Giuliana C Coatti,Marcos C Valadares et al.
Juliana P Gomes et al.
Duchenne muscular dystrophy is the most common and severe form of progressive muscular dystrophy. Previous results showed an increased survival in double knockout mice (dko) when treated with adipose-derived CD146+ cells. In this study, we ...
Richard Lindqvist,Anna K Överby
Richard Lindqvist
Viperin is an interferon (IFN)-stimulated gene product, which is part of the first line of the intracellular response against viral infection. It is a potent antiviral protein, strongly upregulated after IFN-stimulation and virus infection....
CYP24A1 Inhibition Facilitates the Antiproliferative Effect of 1,25(OH)2D3 Through Downregulation of the WNT/β-Catenin Pathway and Methylation-Mediated Regulation of CYP24A1 in Colorectal Cancer Cells [0.03%]
CYP24A1 抑制通过下调Wnt/β-catenin信号传导途径和甲基化介导的CYP24A1调节促进1,25(OH)₂D₃在结直肠癌细胞中的抗增殖作用
Hongyan Sun,Chengwei Jiang,Lele Cong et al.
Hongyan Sun et al.
CYP24A1 is overexpressed in colorectal cancer, and the reason for the dysregulation of CYP24A1 in colorectal cancer is still unknown. In the present study, experiments were designed to test whether CYP24A1 inhibition facilitated the antipro...