ABCB1 1199G>A Polymorphism Affects the Intracellular Accumulation of Antidepressants in LLC-PK1 Recombinant Cell Lines [0.03%]
ABCB1 1199G>A多态性影响了重组细胞系LLC-PK1中抗抑郁药物的细胞内蓄积量
Yun-Ling Gao,Biao He
Yun-Ling Gao
ATP-binding cassette, subfamily B, member 1 (ABCB1) transport, or P-glycoprotein (P-gp), is a transport protein that is involved in the absorption and the efflux of some antidepressants, such as selective serotonin reuptake inhibitors. The ...
A Three Long Noncoding RNA-Based Signature for Oral Squamous Cell Carcinoma Prognosis Prediction [0.03%]
基于三种长链非编码RNA的口腔鳞状细胞癌预后标志物模型
Chenguang Zhao,Huiru Zou,Jinhui Wang et al.
Chenguang Zhao et al.
Oral squamous cell carcinoma (OSCC) is one of the most common malignancies worldwide. Despite relative high 5-year survival rate, delayed diagnosis still hampers its prognosis improvement. Long noncoding RNA (lncRNA) has recently been demon...
Identification of Two Novel Single Nucleotide Polymorphisms in the Promoter Region of the Pig AMP Deaminase 1 Gene Associated with Carcass Traits [0.03%]
猪AMP脱氨酶1基因启动子区两种新型单核苷酸多态性与胴体性状的关联分析
Linjie Wang,Zhe Chao,Yan Wang
Linjie Wang
The AMP deaminase 1 (AMPD1) gene plays an important role in purine nucleotide interconversion and energy metabolism. In this study, two novel single nucleotide polymorphisms (SNPs) (g.-626 G > A and g.-566 A>G) were detected in the proximal...
Molecular Mechanisms of Phosphodiesterase-5 Inhibitors on Neuronal Apoptosis [0.03%]
磷酸二酯酶5抑制剂调控神经元凋亡的分子机制研究进展
Eduardo Duarte-Silva,Christina Alves Peixoto
Eduardo Duarte-Silva
Phosphodiesterase-5 inhibitors (PDE5Is) have been shown to modulate cell death/cell survival in different in vivo and in vitro models of disease by activating many signaling pathways. This review aimed at elucidating how PDE5Is can inhibit ...
Cardiac Fgf-16 Expression Supports Cardiomyocyte Survival and Increases Resistance to Doxorubicin Cytotoxicity [0.03%]
心脏Fgf-16表达支持心肌细胞存活并增加对多柔比星细胞毒性的抵抗能力
Jie Wang,Bo Xiang,Vernon W Dolinsky et al.
Jie Wang et al.
The fibroblast growth factor (FGF) 16 gene is preferentially expressed by cardiomyocytes after birth with levels increasing into adulthood. Null mice and isolated heart studies suggest a role for FGF-16 in cardiac maintenance and survival, ...
TGF-β/Smads Signaling Affects Radiation Response and Prolongs Survival by Regulating DNA Repair Genes in Malignant Glioma [0.03%]
TGF-β/Smads信号通过调控恶性胶质瘤中的DNA修复基因影响放射反应并延长生存期
Sichen Tao,Minli Liu,Dawei Shen et al.
Sichen Tao et al.
To understand the molecular mechanism underlying the causal relationship between aberrant upregulation of transforming growth factor beta (TGF-β) and radio-resistance in glioma. The mouse glioma cell GL261 was irradiated, and relative expr...
GPR30 Attenuates Myocardial Fibrosis in Diabetic Ovariectomized Female Rats: Role of iNOS Signaling [0.03%]
GPR30通过抑制iNOS信号通路减轻糖尿病去卵巢大鼠心肌纤维化的作用研究
Xiaowu Wang,Yanzhen Tan,Bo Xu et al.
Xiaowu Wang et al.
Premenopausal women have a reduced risk for cardiovascular disease. Estrogen deficiency augments cardiac inflammation and oxidative stress and, thereby, aggravates myocardial fibrosis (MF) and diastolic dysfunction in hypertensive female ra...
Optimized Gemcitabine Therapy in Combination with E7 Peptide Immunization Elicits Tumor Cure by Preventing Ag-Specific CTL Inhibition in Animals with Large Established Tumors [0.03%]
优化吉西他滨联合E7多肽免疫治疗通过防止抗原特异性CTL抑制从而根治大肿瘤动物模型中的癌症
Ho-Young Jang,Baek-Sang Han,Byungsuk Kwon et al.
Ho-Young Jang et al.
The role of chemotherapeutic agents in tumor immunotherapy is still controversial. In this study, we test using a TC-1 tumor model whether gemcitabine plus E7 peptide vaccine regimens (E7 peptides+CpG-ODN+anti-4-1BB Abs) may result in tumor...
Suehiro Sakaguchi,Junji Chida
Suehiro Sakaguchi
The normal cellular prion protein, designated PrPC, is a membrane glycoprotein expressed most abundantly in brains, particularly by neurons, and to a lesser extent in non-neuronal tissues including lungs. Conformational conversion of PrPC i...
A Novel Variant of Desmoplakin Is Potentially Associated with Silicosis Risk [0.03%]
降解plakoglobin新型变异体与硅沉着病发病风险相关性研究
Wei Wang,Yuhui Yu,Jing Xiao et al.
Wei Wang et al.
Two genome-wide association studies and one sequencing study have coincidently reported significant associations of single nucleotide polymorphisms (SNPs) in the desmoplakin (DSP) gene with the risk of pulmonary fibrosis (mainly idiopathic ...