Mechanism of LncRNA-MiRNA in Renal Intrinsic Cells of Diabetic Kidney Disease and Potential Therapeutic Direction [0.03%]
长链非编码RNA-微小RNA在糖尿病肾脏疾病肾固有细胞中的作用机制及其潜在治疗方向
Xiyue Tian,Min Zhou,Jingbo Zhang et al.
Xiyue Tian et al.
The occurrence of diabetic kidney disease (DKD), a critical microvascular issue in diabetes, is progressively on the rise. In recent years, long noncoding RNAs (lncRNAs) have garnered considerable attention as a novel and critical layer of ...
Crosstalk Between Plk1 and PTEN in Mitosis Affects Chromosomal Stability [0.03%]
Plk1和PTEN在有丝分裂中的串扰影响染色体稳定性
Wei Li,Xianning Wang,Jiannan Liu et al.
Wei Li et al.
The mitotic phase involves the distribution and regulation of genetic material. Defects in gene regulation can lead to serious errors in genetic transmission, such as increased instability of chromosomes, thereby increasing susceptibility t...
Guardians of the Lung: The Multifaceted Roles of Macrophages in Cancer and Infectious Disease [0.03%]
肺的守护者：巨噬细胞在癌症和传染病中的多种作用
Zhi Liu,Yangjing Ou,Xiaojin He et al.
Zhi Liu et al.
The lung as an organ that is fully exposed to the external environment for extended periods, comes into contact with numerous inhaled microorganisms. Lung macrophages are crucial for maintaining lung immunity and operate primarily through s...
Christina Fissoun,Marta Kovatcheva
Christina Fissoun
Cellular plasticity, which refers to the capacity of cells to alter their identity or potency in response to a variety of stimuli, is emerging as an essential component in tissue repair. Despite the fact that stem cells have historically be...
VIRMA-Mediated the m6A Methylation of SCD Facilitates Wilms' Tumor Progression via AMPK Pathway [0.03%]
VIRMA介导的SCD的m6A甲基化通过AMPK通路促进Wilms'肿瘤进展
Songbai Zhu,Zhen Li
Songbai Zhu
Wilms' tumor (WT) is the most prevalent renal cancer in children. Numerous studies have shown that vir-like n6-methyladenosine (m6A) methyltransferase-associated protein (VIRMA), a necessary component and the largest methyltransferase, cont...
Liquiritin as a Tumor Suppressor Prevents the Development of Breast Cancer via the Epidermal Growth Factor Receptor/Mitogen-Activated Protein Kinase 8 Signaling Pathway [0.03%]
作为一种肿瘤抑制剂荭草素通过表皮生长因子受体/丝裂原激活蛋白激酶8信号通路预防乳腺癌的发展
Ping Li,Lili Yuan,Ying Jiang et al.
Ping Li et al.
Liquiritin, a key component extracted from Glycyrrhiza radix, exhibits a variety of physiological effects. This study investigates the role of liquiritin in the progression of breast cancer. This investigation conducted experiments using tw...
The Role of microRNAs in Lidocaine-Induced Spinal Cord Neurotoxicity: An Exploration Based on Bioinformatics Analysis [0.03%]
microRNA在利多卡因诱导的脊髓神经毒性中的作用：基于生物信息学分析的探索
Longyan Li,Zhong Zhang,Zhengwen Jia et al.
Longyan Li et al.
This study investigated the impact of lidocaine-induced neurotoxicity on microRNA (miRNA) expression in the spinal cord of rats. Sprague-Dawley rats underwent intrathecal catheterization and were randomly assigned to receive either 10% lido...
Lidocaine Inhibits the Proliferation of Non-Small Cell Lung Cancer and Exerts Anti-Inflammatory Effects Through the TLR-9/MyD88/NF-κB Pathway [0.03%]
利多卡因通过TLR-9/MyD88/NF-κB途径抑制非小细胞肺癌的增殖并发挥抗炎作用
Lin Ma,Weiliang Cong,Hongwei Zhang et al.
Lin Ma et al.
Lung cancer represents a significant global health burden, with non-small cell lung cancer (NSCLC) being the most common subtype. The current standard of care for NSCLC has limited efficacy, highlighting the necessity for innovative treatme...
Roksana Shirazi,Juliet Morrison
Roksana Shirazi
The pleural cavity is gaining recognition as an important player in lung infections. Our recent research revealed that pleural macrophages (PMs) migrate from the pleural cavity into the lung during influenza virus infection, contributing to...
Targeting p97/Valosin-Containing Protein Promotes Hepatic Stellate Cell Senescence and Mitigates Liver Fibrosis [0.03%]
靶向p97/含瓦尔苏因蛋白促进肝星状细胞衰老并减轻肝纤维化
Ying Yang,Yuwei Zhang,Lu Wang et al.
Ying Yang et al.
Liver fibrosis, one of the main histological determinants of various chronic liver diseases, currently lacks effective treatment. Hepatic stellate cells (HSCs) are pivotal in the production of extracellular matrix and amplify the fibrogenic...