The Role of microRNAs in Lidocaine-Induced Spinal Cord Neurotoxicity: An Exploration Based on Bioinformatics Analysis [0.03%]
microRNA在利多卡因诱导的脊髓神经毒性中的作用：基于生物信息学分析的探索
Longyan Li,Zhong Zhang,Zhengwen Jia et al.
Longyan Li et al.
This study investigated the impact of lidocaine-induced neurotoxicity on microRNA (miRNA) expression in the spinal cord of rats. Sprague-Dawley rats underwent intrathecal catheterization and were randomly assigned to receive either 10% lido...
Lidocaine Inhibits the Proliferation of Non-Small Cell Lung Cancer and Exerts Anti-Inflammatory Effects Through the TLR-9/MyD88/NF-κB Pathway [0.03%]
利多卡因通过TLR-9/MyD88/NF-κB途径抑制非小细胞肺癌的增殖并发挥抗炎作用
Lin Ma,Weiliang Cong,Hongwei Zhang et al.
Lin Ma et al.
Lung cancer represents a significant global health burden, with non-small cell lung cancer (NSCLC) being the most common subtype. The current standard of care for NSCLC has limited efficacy, highlighting the necessity for innovative treatme...
Roksana Shirazi,Juliet Morrison
Roksana Shirazi
The pleural cavity is gaining recognition as an important player in lung infections. Our recent research revealed that pleural macrophages (PMs) migrate from the pleural cavity into the lung during influenza virus infection, contributing to...
Targeting p97/Valosin-Containing Protein Promotes Hepatic Stellate Cell Senescence and Mitigates Liver Fibrosis [0.03%]
靶向p97/含瓦尔苏因蛋白促进肝星状细胞衰老并减轻肝纤维化
Ying Yang,Yuwei Zhang,Lu Wang et al.
Ying Yang et al.
Liver fibrosis, one of the main histological determinants of various chronic liver diseases, currently lacks effective treatment. Hepatic stellate cells (HSCs) are pivotal in the production of extracellular matrix and amplify the fibrogenic...
Exosome-Delivered Hsa_Circ_0000116 Facilitates Osteosarcoma Cell Malignancy via PI3K/Akt/mTOR and p38/MAPK Pathways [0.03%]
外泌体递送的Hsa_circ_0000116通过PI3K/Akt/mTOR和p38/MAPK途径促进成骨肉瘤细胞恶性表型
Chunsheng Gao,Xiaowei Wang,Huichao Yan et al.
Chunsheng Gao et al.
Exosome-delivered circular RNAs (circRNAs) are recognized as a key mechanism that regulates osteosarcoma (OS) progression. The purpose of this study is to discover the role of a novel circRNA hsa_circ_0000116 from exosomes in OS progression...
Pirfenidone Downregulates eIF6, P311, and TGF-β Expression and Improves Liver Fibrosis Induced by Bile Duct Ligation in Wistar Rats: Evidence for Liver Regeneration [0.03%]
Pirfenidone通过下调eIF6、P311和TGF-β的表达改善Wistar大鼠胆管结扎诱导的肝纤维化：肝脏再生的证据
Zeynab Yousefi,Mitra Nourbakhsh,Abbas Sahebghadam Lotfi
Zeynab Yousefi
Liver fibrosis (LF) is a clinical disorder characterized by inflammation and excessive accumulation of extracellular matrix (ECM). This study investigates the effects of the antifibrotic compound pirfenidone (PFD) on improving LF through hi...
The Interplay Between Obesity and Aging in Breast Cancer and Regulatory Function of MicroRNAs in This Pathway [0.03%]
肥胖和衰老在乳腺癌中的相互作用及微小RNA在此途径中的调节功能
Nima Mahdei Nasir Mahalleh,Mina Hemmati,Arezou Biyabani et al.
Nima Mahdei Nasir Mahalleh et al.
Breast cancer (BC) is a significant contributor to cancer-related deaths in women, and it has complex connections with obesity and aging. This review explores the interaction between obesity and aging in relation to the development and prog...
METTL3-Induced m6A Modification Enhances Hsa_Circ_0136959 Expression to Impair the Tumor Characteristics of Papillary Thyroid Carcinoma via Accelerating Ferroptosis [0.03%]
METTL3诱导的m6A修饰通过促进铁死亡以增强环状RNA hsa_circ_0136959表达从而抑制乳头状甲状腺癌恶性表型的作用及机制研究
Lan Luo,Yanlei Sun,Zongli Cao
Lan Luo
The number of cases of papillary thyroid cancer (PTC) has gone up significantly in recent years, with high recurrence. Numerous reports have highlighted the participation of circular RNAs (circRNAs) in regulating the advancement of cancers,...
Identification and Analysis of Autophagy-Related Genes as Diagnostic Markers and Potential Therapeutic Targets for Tuberculosis Through Bioinformatics [0.03%]
基于生物信息学的结核病诊断标志物及潜在治疗靶点的鉴定与分析（自噬相关基因）
Tingting Luo,Shijie Shen,Yufei Sun et al.
Tingting Luo et al.
According to the World Health Organization, Mycobacterium tuberculosis infections affect approximately 25% of the world's population. There is mounting evidence linking autophagy and immunological dysregulation to tuberculosis (TB). As a re...
Inherited Spinocerebellar Ataxia Segregates with Intra-Familial Genetic Heterogeneity in a Consanguineous Pakistani Family: A Report of a Potential Novel Candidate Gene [0.03%]
一个近亲婚配的巴基斯坦家庭遗传性脊小脑共济失调基因型和表型异质性的研究报告：潜在新候选基因报告
Yaqi Zhou,Jun Xu,Muhammad Asif et al.
Yaqi Zhou et al.
Hereditary spinocerebellar ataxia (SCA) is a group of genetic neurodegenerative disorders caused by a variety of gene variants. At least 44 types of SCAs have been identified to date, and more than 35 genes and hundreds of variants have bee...