Structural Dynamics, Evolutionary Significance, and Functions of Really Interesting New Gene Proteins in Ubiquitination and Plant Stress: A Review [0.03%]
泛素化及植物逆境响应中的RING指新基因蛋白的结构动态、进化意义及其功能综述
Parinita Agarwal,Anjali Chittora,Ayushi Verma et al.
Parinita Agarwal et al.
Abiotic stress causes major crop losses worldwide. Plants have evolved complex intricate signaling network involving transcriptional regulators and posttranslational modifications (PTMs). Ubiquitination-a key PTM-regulates protein degradati...
Inhibition of CCN5 Protects Against Apoptosis and Endoplasmic Reticulum Stress in Bisphenol A-Induced Sertoli Cells via p38/JNK MAPK Signaling Pathway [0.03%]
CCN5抑制通过p38/JNK信号通路保护双酚A诱导的支持细胞免于凋亡和内质网应激
Lijiang Zhao,Xueqing Wu,Qiang Li et al.
Lijiang Zhao et al.
Bisphenol A (BPA) is the most common endocrine disruptor that has toxicity to the reproductive system and male infertility. However, the underlying mechanisms of BPA's toxicity to Sertoli cells remain poorly understood. Cellular communicati...
Rosalind Franklin Society Proudly Announces the 2024 Award Recipient for DNA and Cell Biology [0.03%]
罗萨林德·富兰克林学会自豪地宣布2024年DNA和细胞生物学奖得主
Sabrina Nolan Kline
Sabrina Nolan Kline
Utilizing Long-Read Sequencing for Haplotype Construction and Prevention of Autosomal Dominant Polycystic Kidney Disease Transmission in Mosaicism Family [0.03%]
长读序列表型构建在嵌合家庭常染色体显性多囊肾病遗传风险评估中的应用
Wu Zubo,Jie Liu,Yi Liu et al.
Wu Zubo et al.
This study presents a case of autosomal dominant polycystic kidney disease (ADPKD) involving a mosaic microdeletion in the PKD1 gene and explores the application of long-read sequencing technologies for haplotype construction and preimplant...
Mechanism of LncRNA-MiRNA in Renal Intrinsic Cells of Diabetic Kidney Disease and Potential Therapeutic Direction [0.03%]
长链非编码RNA-微小RNA在糖尿病肾脏疾病肾固有细胞中的作用机制及其潜在治疗方向
Xiyue Tian,Min Zhou,Jingbo Zhang et al.
Xiyue Tian et al.
The occurrence of diabetic kidney disease (DKD), a critical microvascular issue in diabetes, is progressively on the rise. In recent years, long noncoding RNAs (lncRNAs) have garnered considerable attention as a novel and critical layer of ...
Crosstalk Between Plk1 and PTEN in Mitosis Affects Chromosomal Stability [0.03%]
Plk1和PTEN在有丝分裂中的串扰影响染色体稳定性
Wei Li,Xianning Wang,Jiannan Liu et al.
Wei Li et al.
The mitotic phase involves the distribution and regulation of genetic material. Defects in gene regulation can lead to serious errors in genetic transmission, such as increased instability of chromosomes, thereby increasing susceptibility t...
Guardians of the Lung: The Multifaceted Roles of Macrophages in Cancer and Infectious Disease [0.03%]
肺的守护者：巨噬细胞在癌症和传染病中的多种作用
Zhi Liu,Yangjing Ou,Xiaojin He et al.
Zhi Liu et al.
The lung as an organ that is fully exposed to the external environment for extended periods, comes into contact with numerous inhaled microorganisms. Lung macrophages are crucial for maintaining lung immunity and operate primarily through s...
Christina Fissoun,Marta Kovatcheva
Christina Fissoun
Cellular plasticity, which refers to the capacity of cells to alter their identity or potency in response to a variety of stimuli, is emerging as an essential component in tissue repair. Despite the fact that stem cells have historically be...
VIRMA-Mediated the m6A Methylation of SCD Facilitates Wilms' Tumor Progression via AMPK Pathway [0.03%]
VIRMA介导的SCD的m6A甲基化通过AMPK通路促进Wilms'肿瘤进展
Songbai Zhu,Zhen Li
Songbai Zhu
Wilms' tumor (WT) is the most prevalent renal cancer in children. Numerous studies have shown that vir-like n6-methyladenosine (m6A) methyltransferase-associated protein (VIRMA), a necessary component and the largest methyltransferase, cont...
Liquiritin as a Tumor Suppressor Prevents the Development of Breast Cancer via the Epidermal Growth Factor Receptor/Mitogen-Activated Protein Kinase 8 Signaling Pathway [0.03%]
作为一种肿瘤抑制剂荭草素通过表皮生长因子受体/丝裂原激活蛋白激酶8信号通路预防乳腺癌的发展
Ping Li,Lili Yuan,Ying Jiang et al.
Ping Li et al.
Liquiritin, a key component extracted from Glycyrrhiza radix, exhibits a variety of physiological effects. This study investigates the role of liquiritin in the progression of breast cancer. This investigation conducted experiments using tw...