The Active Ingredients of Herbs Targeting Long Noncoding RNA: A Potential Alternative to Treat Parenchymal Organ Inflammation and Fibrosis in the Future [0.03%]
针对长链非编码RNA的草药活性成分：未来治疗实质器官炎症和纤维化的潜在替代疗法
Min Zhou,Biyu Tan,Jian Liu et al.
Min Zhou et al.
We review current studies on the anti-inflammatory and antifibrotic effects of herbal medicines and their active ingredients. To explore how these active ingredients target long noncoding RNA to exert their effects, we searched PubMed and C...
Therapeutic Efficacy of Melatonin and Flutamide Combination in Safety for Prostate Cancer: An In Vitro Study [0.03%]
褪黑素联合氟他胺安全有效治疗前列腺癌的疗效：一项体外研究
Reza Omid,Fatemeh Khatami,Ramin Rahimnia et al.
Reza Omid et al.
The side effects associated with flutamide as a first-line drug treating prostate cancer, including hepatotoxicity, the aim of this research was to use melatonin as an anticancer candidate to reduce the dose of flutamide and reduce its side...
In Vitro Reconstitution of SPO11-Mediated DNA Cleavage Sheds New Light on the Initiation of Meiotic Recombination [0.03%]
体外重组SPO11介导的DNA切割现象使人们能够更加深入地了解了重组诱导的新见解
Cédric Oger,Corentin Claeys Bouuaert
Cédric Oger
Three recent studies report the first biochemical reconstitution of DNA double-strand break (DSB) formation by SPO11, the topoisomerase-derived transesterase that initiates meiotic recombination in sexually reproducing organisms. A central ...
Modulation of Cuproptosis Pathway Genes (DLAT, FDX1) and Antioxidant Enzyme Activities in Obese Mice in Response to Quercetin and Calorie Restriction [0.03%]
槲皮素和限食对肥胖小鼠铜死亡途径基因（DLAT，FDX1）及抗氧化酶活性的影响
Nima Mahdei Nasirmahalleh,Mina Hemmati,Negin Parsamanesh et al.
Nima Mahdei Nasirmahalleh et al.
Cuproptosis is a new mode of cell death that is closely related to mitochondrial stress. The purpose of this study is to investigate the amount of copper, copper-associated genes DLAT and FDX1 oxidative stress (OS) status in obesity. Since ...
Ambika Chamoli,Priyanka Patel Vatsa,Vinal Upadhyay et al.
Ambika Chamoli et al.
Chromatin immunoprecipitation (ChIP) assesses DNA-proteins interactions and hence helps to generate intricate relationships and vital information. ChIP determines the genomic location of specific proteins or post-translational modifications...
The Therapeutic Potential of Extracellular Vesicles in Sepsis Management [0.03%]
脓毒症治疗中细胞外囊泡的潜在作用机制研究进展
Laifa Kong,Qigang Huang,Jianghua Cheng et al.
Laifa Kong et al.
Sepsis is a serious systemic inflammatory condition triggered by a variety of pathogens, including bacteria and viruses, that can result in multiple organ failure and a life-threatening situation. Despite advances in medical care, the morta...
The Solute Carrier Family 47 Member 1, Transcriptionally Regulated by GATA Binding Protein 6, Inhibits Ferroptosis in Gastric Cancer [0.03%]
GATA结合蛋白6转录调控的溶质载体家族47成员1抑制胃癌铁死亡
Chang&#x;e Shi,Hezhong Yan,Qihong Zhao et al.
Chang&#x;e Shi et al.
Gastric cancer (GC) remains the leading cause of cancer deaths worldwide. GC development is a multistep and multifactorial process, and the molecular characterization of the multistage progression of gastric lesions to GC is poorly understo...
Ying Wang,Shu Wang,Leijia Li et al.
Ying Wang et al.
The taxonomic classification of Babu tea (Family Theaceae) was preliminarily investigated by analyzing its epigenetic morphology and chromosomal features. Morphological observations of three Babu Tea phenotypes (red flower/purple bud, pink ...
Association Between MUC13 Gene Polymorphisms and Exacerbations of Asthma Under the Influence of Cigarette Smoking [0.03%]
MUC13基因多态性与吸烟诱发的哮喘急性发作的相关性研究
Ji-Hong Bang,Ji-Hye Son,Jong-Uk Lee et al.
Ji-Hong Bang et al.
Acute exacerbation of asthma is often characterized by increased mucus production and hypersecretion. While mucins are believed to play a role in the pathogenesis and pathophysiology of airway diseases, no genetic studies on mucin genes hav...
Christina T Stankey,James Christopher Lee
Christina T Stankey
Autoimmune and inflammatory diseases are rising globally yet widely effective therapies remain elusive. Most treatments have limited efficacy, significant potential side effects, or eventually lose response, underscoring the urgent need for...