In Vitro Study of the Damaging Effects of the Fungicide Dithianon on DNA Structure by Spectroscopic Techniques [0.03%]
光谱技术结合DNA模板聚合酶链式反应法检测 fungicide dithianon 对人血淋巴细胞的致突变性体外试验
Parvaneh Pakravan
Parvaneh Pakravan
The common broad-spectrum protectant fungicide known as Dithianon is utilized in agriculture to manage pests; however, it could pose risks to human health. Dithianon may be associated with health problems due to its affinity for DNA. The in...
Genetic Underpinnings of Mitochondrial Cardiomyopathy: A Scoping 2010-2024 Update [0.03%]
线粒体心肌病的遗传基础：2010-2024年度查新综述更新报告中文版
Insaf Moudian,Joaira Bakkach,Zeineb Zian et al.
Insaf Moudian et al.
Mitochondrial cardiomyopathy is a rare specific myocardial condition characterized by abnormal myocardium structure and/or function due to mitochondrial respiratory chain deficiency. This cardiac disorder results from mutations in mitochond...
Mapping Cophosphoregulation Networks Linked to Transcriptional Regulator Bromodomain-Containing Protein 4 [0.03%]
泛素连接酶BRD4调控的磷酸化修饰底物网络映射
Anjana C Lalu,Fathimathul Lubaba,Athira Perunelly Gopalakrishnan et al.
Anjana C Lalu et al.
Bromodomain-containing protein 4 (BRD4) is a pivotal transcriptional regulator implicated in cancer, fibrosis, and inflammation, yet its phospho-regulatory network remains underexplored. This study leverages an extensive analysis of 1000 qu...
UBE2C, Regulated by n6-methyladenosine Methyltransferase METTL3, Is an Oncogene in Retinoblastoma via PI3K-AKT Pathway [0.03%]
N6-甲基腺苷甲基转移酶METTL3调控的UBE2C通过PI3K-AKT信号通路在视网膜母细胞瘤中发挥致癌作用
Lan Chen,Songhua Mei
Lan Chen
Retinoblastoma (RB) arising from the retina's primitive neural precursor cells is a highly aggressive pediatric ocular malignancy. Ubiquitin-conjugating enzyme E2C (UBE2C) is implicated in carcinogenesis, but its role and mechanism in RB re...
Fertilization Initiates Seed Nutrition via Phloem End by a Callose Degradation Enzyme [0.03%]
识别并降解卵细胞壁以启动种子营养的机制
Ryushiro D Kasahara
Ryushiro D Kasahara
Why plants need fertilization to produce seeds has long been discussed. We recently identified a new specialized tissue required for seed formation at the ovule's chalazal end, showing the final form of the phloem end and supporting its tra...
Granzyme K, Regulated by the N6-Methyladenosine Methyltransferase Wilms' tumor 1-associate protein, Enhances Myocardial Infarction Injury [0.03%]
N6-甲基腺苷甲基转移酶Wilm's肿瘤1相关蛋白调控的颗粒酶K促进心肌梗死损伤
Qing Lyu,Le Li
Qing Lyu
Myocardial infarction (MI) is a major contributor to death in contemporary society, and this mechanism involves n6-methyladenosine (m6A) modification. In this study, we studied the m6A mechanisms involved in MI. For this purpose, an H9C2 ce...
The Active Ingredients of Herbs Targeting Long Noncoding RNA: A Potential Alternative to Treat Parenchymal Organ Inflammation and Fibrosis in the Future [0.03%]
针对长链非编码RNA的草药活性成分：未来治疗实质器官炎症和纤维化的潜在替代疗法
Min Zhou,Biyu Tan,Jian Liu et al.
Min Zhou et al.
We review current studies on the anti-inflammatory and antifibrotic effects of herbal medicines and their active ingredients. To explore how these active ingredients target long noncoding RNA to exert their effects, we searched PubMed and C...
Therapeutic Efficacy of Melatonin and Flutamide Combination in Safety for Prostate Cancer: An In Vitro Study [0.03%]
褪黑素联合氟他胺安全有效治疗前列腺癌的疗效：一项体外研究
Reza Omid,Fatemeh Khatami,Ramin Rahimnia et al.
Reza Omid et al.
The side effects associated with flutamide as a first-line drug treating prostate cancer, including hepatotoxicity, the aim of this research was to use melatonin as an anticancer candidate to reduce the dose of flutamide and reduce its side...
In Vitro Reconstitution of SPO11-Mediated DNA Cleavage Sheds New Light on the Initiation of Meiotic Recombination [0.03%]
体外重组SPO11介导的DNA切割现象使人们能够更加深入地了解了重组诱导的新见解
Cédric Oger,Corentin Claeys Bouuaert
Cédric Oger
Three recent studies report the first biochemical reconstitution of DNA double-strand break (DSB) formation by SPO11, the topoisomerase-derived transesterase that initiates meiotic recombination in sexually reproducing organisms. A central ...
Modulation of Cuproptosis Pathway Genes (DLAT, FDX1) and Antioxidant Enzyme Activities in Obese Mice in Response to Quercetin and Calorie Restriction [0.03%]
槲皮素和限食对肥胖小鼠铜死亡途径基因（DLAT，FDX1）及抗氧化酶活性的影响
Nima Mahdei Nasirmahalleh,Mina Hemmati,Negin Parsamanesh et al.
Nima Mahdei Nasirmahalleh et al.
Cuproptosis is a new mode of cell death that is closely related to mitochondrial stress. The purpose of this study is to investigate the amount of copper, copper-associated genes DLAT and FDX1 oxidative stress (OS) status in obesity. Since ...