Bile Acid-Mediated Interactions with Various Cell Types in the Cholestatic Liver [0.03%]
胆汁淤积性肝病时胆酸与各种细胞类型的相互作用
Guanyi He,Jie Qing
Guanyi He
Bile acids (BAs) have garnered significant attention due to their novel roles in modulating diverse host physiological processes. They play a crucial role in nutrient transport, organelle function, and maintaining the systemic balance of pr...
Effect of Licorice (Glycyrrhiza glabra)-Silver Nanoparticles on Liver and Kidney Histopathological Features in Common Carp Fish (Cyprinus carpio) [0.03%]
甘草(S Glycyrrhizae)-银纳米颗粒对鲤鱼(Cyrpinus carpio)肝、肾组织病理学特征的影响
Hawre K Faraj,Nasreen M Abdulrahman
Hawre K Faraj
The increasing use of silver nanoparticles (AgNPs) in aquaculture has raised concerns regarding their potential toxic effects on fish health, particularly on vital organs, such as the liver and kidneys. Licorice (Glycyrrhiza glabra) root, k...
Exosome-Mediated circRNA Hsa_Circ_0113050 Enhances Colorectal Cancer Cell Malignancy by Interacting with EIF4A3 [0.03%]
circRNA Hsa_Circ_0113050通过与EIF4A3互作促进结直肠癌细胞恶性表型的外泌体介导机制研究
Yuan Tian,Chen He
Yuan Tian
The exosome-mediated circular RNAs (circRNAs) play a crucial role in tumorigenesis. The present study investigated the role of the exosome-mediated circRNA hsa_circ_0113050 in colorectal cancer (CRC) through its interaction with the eukaryo...
In Vitro Study of the Damaging Effects of the Fungicide Dithianon on DNA Structure by Spectroscopic Techniques [0.03%]
光谱技术结合DNA模板聚合酶链式反应法检测 fungicide dithianon 对人血淋巴细胞的致突变性体外试验
Parvaneh Pakravan
Parvaneh Pakravan
The common broad-spectrum protectant fungicide known as Dithianon is utilized in agriculture to manage pests; however, it could pose risks to human health. Dithianon may be associated with health problems due to its affinity for DNA. The in...
Genetic Underpinnings of Mitochondrial Cardiomyopathy: A Scoping 2010-2024 Update [0.03%]
线粒体心肌病的遗传基础：2010-2024年度查新综述更新报告中文版
Insaf Moudian,Joaira Bakkach,Zeineb Zian et al.
Insaf Moudian et al.
Mitochondrial cardiomyopathy is a rare specific myocardial condition characterized by abnormal myocardium structure and/or function due to mitochondrial respiratory chain deficiency. This cardiac disorder results from mutations in mitochond...
Mapping Cophosphoregulation Networks Linked to Transcriptional Regulator Bromodomain-Containing Protein 4 [0.03%]
泛素连接酶BRD4调控的磷酸化修饰底物网络映射
Anjana C Lalu,Fathimathul Lubaba,Athira Perunelly Gopalakrishnan et al.
Anjana C Lalu et al.
Bromodomain-containing protein 4 (BRD4) is a pivotal transcriptional regulator implicated in cancer, fibrosis, and inflammation, yet its phospho-regulatory network remains underexplored. This study leverages an extensive analysis of 1000 qu...
UBE2C, Regulated by n6-methyladenosine Methyltransferase METTL3, Is an Oncogene in Retinoblastoma via PI3K-AKT Pathway [0.03%]
N6-甲基腺苷甲基转移酶METTL3调控的UBE2C通过PI3K-AKT信号通路在视网膜母细胞瘤中发挥致癌作用
Lan Chen,Songhua Mei
Lan Chen
Retinoblastoma (RB) arising from the retina's primitive neural precursor cells is a highly aggressive pediatric ocular malignancy. Ubiquitin-conjugating enzyme E2C (UBE2C) is implicated in carcinogenesis, but its role and mechanism in RB re...
Fertilization Initiates Seed Nutrition via Phloem End by a Callose Degradation Enzyme [0.03%]
识别并降解卵细胞壁以启动种子营养的机制
Ryushiro D Kasahara
Ryushiro D Kasahara
Why plants need fertilization to produce seeds has long been discussed. We recently identified a new specialized tissue required for seed formation at the ovule's chalazal end, showing the final form of the phloem end and supporting its tra...
Granzyme K, Regulated by the N6-Methyladenosine Methyltransferase Wilms' tumor 1-associate protein, Enhances Myocardial Infarction Injury [0.03%]
N6-甲基腺苷甲基转移酶Wilm's肿瘤1相关蛋白调控的颗粒酶K促进心肌梗死损伤
Qing Lyu,Le Li
Qing Lyu
Myocardial infarction (MI) is a major contributor to death in contemporary society, and this mechanism involves n6-methyladenosine (m6A) modification. In this study, we studied the m6A mechanisms involved in MI. For this purpose, an H9C2 ce...