Nucleosome Linker Length and Distribution as Major Players in Epigenetic Regulation: Insights from Cryo-Electron Microscopy and Modeling of Retina Cell Maturation [0.03%]
基于冷冻电子显微镜和视网膜细胞成熟建模对表观遗传调控的研究：核小体连接子长度和分布起主要作用
Tamar Schlick,Sergei Grigoryev
Tamar Schlick
We summarize recent findings on the conformational differences of chromatin fibers in immature versus mature retina cells due to different nucleosome linker length values and distributions, as revealed by cryo-electron microscopy and modeli...
m6A Modification Destabilizes Prss8 and Activates Hepatic Stellate Cells via TLR4-Mediated Inflammatory Responses [0.03%]
m6A修饰通过TLR4介导的炎症反应降低Prss8并激活肝星状细胞
Huimei Chen,Linhui Zhang,Lili Zhang et al.
Huimei Chen et al.
The 6-methyladenine (m6A) modification plays a major role in various diseases. Serine protease 8 (Prss8) contributes to the initiation and progression of liver fibrosis (LF). However, the mechanism by which the m6A modification of Prss8 ind...
KIAA1429 Induces the Tumorigenesis of Clear Cell Renal Cell Carcinoma via Regulating the N6-Methyladenosine Modification of Thymosin Beta-10 [0.03%]
KIAA1429通过调节胸腺素β10的N6甲基腺苷修饰诱导透明细胞肾细胞癌的发生发展
Sheng Jin,Fang Liu
Sheng Jin
N6-Methyladenosine (m6A) is a reversible RNA modification that regulates tumorigenesis. KIAA1429, a critical component of the m6A methyltransferase complex, has an unclear role in clear cell renal cell carcinoma (ccRCC). Here, we investigat...
New Insights into Host Genetic Ancestry as a Risk Factor for Dengue Disease [0.03%]
新的关于宿主遗传祖先作为登革热发病风险因素的见解
Simon M Barratt-Boyes,Priscila M S Castanha
Simon M Barratt-Boyes
Dengue is the most important mosquito-borne viral infection of humans worldwide. Genetic ancestry of the host is a significant risk factor for severe dengue, but the mechanisms are not known. Recent findings using human skin explants from g...
Sourabh Soni,Yohannes A Mebratu
Sourabh Soni
This essay focuses on a key host factor, the protein BIK (Bcl-2-interacting killer), that influences the severity of influenza A virus (IAV) infections. Our recent research published in Proceedings of the National Academy of Sciences descri...
Probiotic Feed Additive from Indigenous Bacillus subtilis Enhances Growth and Health in Common Carp (Cyprinus carpio) [0.03%]
源于土生芽孢杆菌的益生菌饲料添加剂能提高鲤鱼（ Cyprinus carpio）的生长和健康状况
Havan Dwud Sleman,Nasreen Mohialddin Abdulrahman
Havan Dwud Sleman
Probiotics sourced from host-adapted microbes represent a sustainable innovation in aquaculture nutrition, aiming to replace antibiotics and enhance fish health. However, studies evaluating indigenous probiotic strains specifically adapted ...
Mutations in Osteoclast Genes as Causes of Osteoclast-Related Diseases [0.03%]
破骨细胞相关疾病的发生与破骨细胞基因突变的关系
Jelena M Živković,Jelena G Najdanović,Stevo J Najman
Jelena M Živković
Osteoclasts, as the only cells capable of resorbing bone, play a significant role in all processes that take place at the level of bone tissue and are involved in the development of the skeleton, maintenance of its integrity, repair, and re...
From Warburg to Warnings: A Genomic Approach to Oral Cancer Surveillance [0.03%]
从沃夫博格到预警：口腔癌监测的基因组学方法研究
Denis C Baiju,Logeswaran V M,Rosy Mondal
Denis C Baiju
Mitochondria, originating from symbiotic ancestors, are acknowledged as the powerhouses of the cell. Their relevance to various cancer types is underscored by altered glucose metabolism (Warburg effect). Mitochondrial DNA (mtDNA) plays a cr...
Pyruvate dehydrogenase complex component B: A Gene Associated with Cuproptosis and Encoding the Beta Subunit of Pyruvate Dehydrogenase Is Involved in the Oxidative Decarboxylation Reaction [0.03%]
丙酮酸脱氢酶复合物B成分：与铜死亡相关的一个基因，编码参与氧化脱羧反应的丙酮酸脱氢酶β亚基
Ruida Liu,Fajuan Tang,Xiaoyan Zhang et al.
Ruida Liu et al.
Cuproptosis is a regulated cell death mechanism that has recently been identified and is distinct from other known cell death mechanisms (e.g., apoptosis, Ferroptosis, necrotic apoptosis, etc.). Cuproptosis causes oligomer formation through...