Ubiquitin-Specific Proteases in Breast Cancer: Unraveling Oncogenic Roles and Therapeutic Opportunities [0.03%]
泛素特异性蛋白酶在乳腺癌中的致癌作用及治疗机会研究
Jitendra Gupta,Nisreen Salah Majeed,Mudhr Kedhem et al.
Jitendra Gupta et al.
The ubiquitin-proteasome system (UPS) is a crucial determinant of protein stability and activity in various aspects of physiological function and disease development. The well-characterized class of regulatory enzymes within the UPS is deub...
Integrative Analysis of miRNA and CpG Methylation with the Transcriptome of Lung-Derived Fibroblasts Identifies Epigenetically Regulated Genes in Idiopathic Pulmonary Fibrosis [0.03%]
整合分析肺来源成纤维细胞的miRNA和CpG甲基化与转录组鉴定特发性肺纤维化的表观遗传调控基因
Min Kyung Kim,Jung Hyun Kim,Hun Gyu Hwang et al.
Min Kyung Kim et al.
Idiopathic pulmonary fibrosis (IPF) arises from interactions between genetic predisposition and environmental exposures (exposome). This study used an integrative multi-omics to identify co-regulated genes in IPF fibroblasts. Differentially...
MAPK Signaling and the Tumor Microenvironment: Drivers of Cancer Development and Resistance [0.03%]
MAPK信号和肿瘤微环境：癌症发生和发展耐药性的驱动因素
Hamza Abu Owida,Suleiman Ibrahim Mohammad,Pareshkumar N Patel et al.
Hamza Abu Owida et al.
The mitogen-activated protein kinase (MAPK) signaling pathway plays a key role in regulating a number of cellular processes, including proliferation, differentiation, apoptosis, and cellular responses to stress. In cancer, abnormal activati...
The Significance of the Piezo1-Mediated Mechanotransduction Pathway in Normal Morphogenesis [0.03%]
Piezo1介导的机械转导通路在正常形态发生中的意义
Reza Rezaei,Yaser Mohammadi,Zohreh Rezaei et al.
Reza Rezaei et al.
Mechanical forces are fundamental drivers of morphogenesis, yet the molecular mechanisms that convert these physical cues into transcriptional responses remain incompletely understood. This review synthesizes current evidence identifying th...
The Role of LncRNA ANRIL in Hepatocellular Carcinoma Tumorigenesis: Regulation of the p53 Signaling Pathway [0.03%]
长链非编码RNA ANRIL在肝细胞癌发生中的作用：对p53信号通路的调控
Jieting Liu,Minglu Ding,Ping He et al.
Jieting Liu et al.
The long noncoding RNA (lncRNA) antisense noncoding RNA in the INK4 locus (ANRIL) expression is upregulated in hepatocellular carcinoma (HCC) tissues, and decreased ANRIL expression inhibits cell proliferation, metastasis, and invasion and ...
RNPS1 Promotes the Progression of Nonsmall Cell Lung Cancer via ETV4-Mediated Ferroptosis [0.03%]
RNPS1通过ETS转录因子ETV4介导的铁死亡促进非小细胞肺癌进展
Lingling Wang,Shitao Mao,Yue Sun et al.
Lingling Wang et al.
Ferroptosis plays a crucial role in regulating tumor growth and represents a promising therapeutic target for nonsmall cell lung cancer (NSCLC). RNA-binding protein with serine-rich domain 1 (RNPS1) has been closely associated with the deve...
Qingqing Yang,Yunpeng Zhao,Li Zhu et al.
Qingqing Yang et al.
Copper plays an essential role in numerous biological functions, requiring tight regulation to prevent toxicity and health complications. Cuproptosis is a recently discovered form of regulated cell death that occurs due to intracellular cop...
Ferroptosis Profiles of Human Mesenchymal Stromal Cell Subsets at the Single-Cell Level [0.03%]
人基质细胞亚群单细胞水平的铁死亡图谱
Xin Wen,Shuai Ding,Yujie Zhou et al.
Xin Wen et al.
Mesenchymal stromal cells (MSCs) have been widely used in clinical trials for various diseases, due to their broad differentiation potential and effective immunomodulatory effects. However, the cell death profiles of MSC subsets remain inad...
Mesenchymal Stem Cells Preconditioned with Herbal Bioactive Components: Exosome-Mediated microRNA Mechanisms and Therapeutic Potential for Chronic Kidney Disease [0.03%]
中药活性成分预处理的间充质干细胞：外泌体介导的microRNA机制及慢性肾脏病治疗潜能
Lili Lu,Zheng Zhang,Jian Liu et al.
Lili Lu et al.
The development of effective therapeutic strategies for chronic kidney disease (CKD) remains a central focus of contemporary medical research. Mesenchymal stem cells (MSCs) have emerged as a highly promising therapeutic modality for CKD, pr...
LncRNA Gm17586 Reduces HSCs Activation by Increasing SIRT1 Transcript Activity to Enhance Smad3 Deacetylation [0.03%]
Gm17586 lncRNA通过增加SIRT1的转录活性促进Smad3去乙酰化从而减少HSC激活的功能研究
Linhui Zhang,Huimei Chen,Xue Pang et al.
Linhui Zhang et al.
Long noncoding RNAs (lncRNAs) play crucial roles in liver fibrosis (LF). We previously showed that the key lncRNA Gm17586 is involved in LF, but its molecular mechanism remains unclear. Primary hepatic stellate cells (HSCs) were isolated fr...