Integrating Network Pharmacology, Transcriptome Analysis, and In Vitro Experiment to Investigate Molecular Mechanism of Liensinine on Pancreatic Cancer [0.03%]
基于网络药理学、转录组分析及体外实验探究LIENSINE治疗胰腺癌的分子机制
Jiawei Cao,Jiaqi Yao,Shoudi He et al.
Jiawei Cao et al.
Liensinine (LIE), a bioactive alkaloid from Nelumbo nucifera, exhibits proapoptotic and anticancer properties. Its effect and mechanism in pancreatic cancer remain unexplored, representing a novel research direction. We employed an integrat...
SLFN11 Enhances PARPi Sensitivity in Ovarian Cancer via Ubiquitin-Mediated Stabilization [0.03%]
SLFN11通过泛素介导的稳定增强卵巢癌对PARP抑制剂的敏感性
Minjie Liu,Hongfeng Li,Fang Zhang et al.
Minjie Liu et al.
Schlafen family member 11 (SLFN11), implicated in cancer drug resistance, may improve poly(ADP-ribose) polymerase inhibitor (PARPi) efficacy. This study investigates SLFN11's role in epithelial ovarian cancer (EOC) progression and its influ...
Bacteriophage-Encoded Small RNAs: Emerging Tools for Phage Therapy and Antibacterial Intervention [0.03%]
噬菌体编码的小RNA分子：噬菌体治疗和抗菌干预的新工具
Aviezer Silverman,Sahar Melamed
Aviezer Silverman
Bacteriophages (phages) are viruses that specifically infect bacteria and play a central role in shaping microbial communities and bacterial evolution. Beyond their protein-coding genes, phage genomes were found recently to encode small RNA...
Silent Signals: The Expanding Role of Cell-Free DNA in Women's Health, Pregnancy, and Reproductive Medicine [0.03%]
无言的信号：细胞-free DNA在女性健康、妊娠和生殖医学中的作用日益重要
Matin Dolatabadi,Mahdieh Mondanizadeh
Matin Dolatabadi
Cell-free DNA (cfDNA) is an emerging biomarker detectable in various bodily fluids, with promising implications across a wide range of clinical domains. Its minimally invasive nature, short half-life, and ability to reflect tissue-specific ...
Compensatory Gene Regulation Following Survivin Inhibition in MDA-MB-231 Cells [0.03%]
survivin抑制后MDA-MB-231细胞中的补偿性基因调节作用
Manuel Antonio Martínez-Sifuentes,Juan Ramos-Treviño,Magali Espinosa-Castilla et al.
Manuel Antonio Martínez-Sifuentes et al.
Breast cancer is the most diagnosed cancer in women and the second leading cause of cancer-related mortality worldwide. Advances in genetic technology have highlighted the heterogeneity of breast cancer, composed of various biological subty...
First-in-Class Small Molecule Inhibitor of Oncogene AVIL in Glioblastoma [0.03%]
针对胶质母细胞瘤癌基因AVIL的首创新型小分子抑制剂
Zhongqiu Xie,Sophia Xie,Hui Li
Zhongqiu Xie
Glioblastoma multiforme (GBM) is the most prevalent and aggressive malignant primary brain tumor, marked by rapid growth, extensive invasiveness, and a median survival of only ∼15 months despite current multimodal therapy. To identify new ...
Dietary Saturated Fatty Acids as Evolutionarily Conserved Signals of Immune Activation [0.03%]
饱和脂肪酸作为进化上保守的免疫激活信号
Sam J McCright,Olivia Harding,David A Hill
Sam J McCright
Dietary fat is comprised largely of fatty acids (FAs), which function not only as metabolic substrates but also as key intracellular signaling molecules. Saturated fatty acids (SFAs) have long been linked to metabolic and inflammatory disea...
Carla E M Golden,Christine M Constantinople
Carla E M Golden
Estrogenic hormones act throughout the brain, yet the basic mechanisms by which hormones influence neural circuit dynamics and computations, especially during complex behaviors, are unclear. Exogenous estrogenic hormones modulate dopamine s...
Impact of FTO Genetic Variants on Colorectal Cancer Risk: A Case-Control Study [0.03%]
FTO基因多态性与结直肠癌发病风险的相关性研究——一项病例对照研究
Zimo Yan,Xianlei Zhou,Wenlong Wu et al.
Zimo Yan et al.
This study aimed to assess the association between fat mass and obesity-associated (FTO) genetic variants and colorectal cancer (CRC) risk in a retrospective case-control cohort. FTO expression in CRC versus normal tissues was analyzed via ...
N6-Methylation Modification: Its Role in Regulating Cell Senescence and Inflammation in Osteoarthritis and Intervertebral Disc Degeneration [0.03%]
N6-甲基化修饰在骨关节炎和椎间盘退变中的作用机制研究进展
Rui Sun,Yan Zhou,Xiao-Tao Wu et al.
Rui Sun et al.
N6-methyladenosine (m6A) methylation, the most prevalent internal mRNA modification in eukaryotes, plays a crucial role in regulating various biological processes. Recent advancements reveal its significant involvement in osteoarthritis (OA...