The Impact of Homeopathic Medicines on Dental Stem Cells: An Experimental Study [0.03%]
家用药物对牙髓干细胞的影响：一项实验研究
Marli Cristina Pereira,Thainá Beatriz Soares,Jeferson Luis de Oliveira Stroparo et al.
Marli Cristina Pereira et al.
This study investigated the influence of homeopathic medicines (HMs) on the in vitro behavior of stem cells from human exfoliated deciduous teeth (SHED). The HMs Symphytum officinale (SO), Calcarea carbonica (CC), and Calcarea phosphorica (...
Intervention Study on the Regulation of circAno6/miR-296-3p/TLR4 Signaling Axis by Shugan Jianpi Formula to Alleviate Inflammation Cascade and Inhibit HSC Activation [0.03%]
舒肝健脾方调节circAno6/miR-296-3p/TLR4信号轴干预肝纤维化的实验研究
Qian Wu,Tingting Li,Jing Qu et al.
Qian Wu et al.
Liver fibrosis (LF) is a fibrotic and inflammatory condition resulting from chronic liver damage, and the activation of hepatic stellate cells (HSCs) is the central event. Our prior research has revealed that the circAno6/miR-296-3p/Toll-li...
Dent Disease 1 Associated with a Rare Novel Renal Chloride Channel 5 Variant in a Chinese Family [0.03%]
一中国家系罕见的新肾氯通道CLCN5突变导致的 Dent病1病例报告
Si-Yuan Zhang,Hao Huang,Zi-Jie Yu et al.
Si-Yuan Zhang et al.
Dent disease 1, an X-linked recessive proximal tubulopathy most commonly caused by CLCN5 variants, often presents with heterogeneous and nonspecific phenotypes that hinder clinical diagnosis in the absence of molecular data. We investigated...
Beyond the Tumor Mass: From Initiating Clones to Overt Isocitrate Dehydrogenase-Mutant Gliomas [0.03%]
超越肿瘤实质：IDH突变型胶质瘤从启动克隆到明确诊断的发展过程
Jung Won Park,Jeong Ho Lee,Seok-Gu Kang
Jung Won Park
Isocitrate dehydrogenase (IDH)-mutant gliomas are primary malignant brain tumors defined by recurrent mutations in IDH1/2 genes and characterized by distinct molecular subtypes and relatively favorable clinical outcomes. Although these muta...
An Assembly of the Global Phosphoproteomic Network of an Underexplored Kinase CDK17: Possible Implications in Cell Cycle Regulation [0.03%]
一个未被充分研究的蛋白激酶CDK17的全球磷酸蛋白质组网络汇集分析及其对细胞周期调控的意义探讨
Ashika Bangera,Fathimathul Lubaba,Athira Perunelly Gopalakrishnan et al.
Ashika Bangera et al.
Cyclin-dependent kinase 17 (CDK17) is an understudied member of the PCTAIRE family of CDKs, with phosphorylation-guided molecular mechanism being underexplored. In this study, an in-depth mass spectrometry-based phosphoproteomics data integ...
Integrating Network Pharmacology, Transcriptome Analysis, and In Vitro Experiment to Investigate Molecular Mechanism of Liensinine on Pancreatic Cancer [0.03%]
基于网络药理学、转录组分析及体外实验探究LIENSINE治疗胰腺癌的分子机制
Jiawei Cao,Jiaqi Yao,Shoudi He et al.
Jiawei Cao et al.
Liensinine (LIE), a bioactive alkaloid from Nelumbo nucifera, exhibits proapoptotic and anticancer properties. Its effect and mechanism in pancreatic cancer remain unexplored, representing a novel research direction. We employed an integrat...
SLFN11 Enhances PARPi Sensitivity in Ovarian Cancer via Ubiquitin-Mediated Stabilization [0.03%]
SLFN11通过泛素介导的稳定增强卵巢癌对PARP抑制剂的敏感性
Minjie Liu,Hongfeng Li,Fang Zhang et al.
Minjie Liu et al.
Schlafen family member 11 (SLFN11), implicated in cancer drug resistance, may improve poly(ADP-ribose) polymerase inhibitor (PARPi) efficacy. This study investigates SLFN11's role in epithelial ovarian cancer (EOC) progression and its influ...
Bacteriophage-Encoded Small RNAs: Emerging Tools for Phage Therapy and Antibacterial Intervention [0.03%]
噬菌体编码的小RNA分子：噬菌体治疗和抗菌干预的新工具
Aviezer Silverman,Sahar Melamed
Aviezer Silverman
Bacteriophages (phages) are viruses that specifically infect bacteria and play a central role in shaping microbial communities and bacterial evolution. Beyond their protein-coding genes, phage genomes were found recently to encode small RNA...
Silent Signals: The Expanding Role of Cell-Free DNA in Women's Health, Pregnancy, and Reproductive Medicine [0.03%]
无言的信号：细胞-free DNA在女性健康、妊娠和生殖医学中的作用日益重要
Matin Dolatabadi,Mahdieh Mondanizadeh
Matin Dolatabadi
Cell-free DNA (cfDNA) is an emerging biomarker detectable in various bodily fluids, with promising implications across a wide range of clinical domains. Its minimally invasive nature, short half-life, and ability to reflect tissue-specific ...