Aspirin Challenge-Induced Genome-Wide DNA Methylation Profile of Peripheral Blood Lymphocytes in Aspirin-Exacerbated Respiratory Disease [0.03%]
阿司匹林加剧呼吸疾病中阿司匹林激发诱导的外周血淋巴细胞DNA全基因组甲基化分布特征研究
Jong-Uk Lee,Hun Soo Chang,Ji-Su Shim et al.
Jong-Uk Lee et al.
Genetic variation and epigenetic factors are thought to contribute to the development of hypersensitivity to aspirin. DNA methylation fluctuates dynamically throughout the day. To discover new CpG methylation in lymphocytes associated with ...
Cloning and Expression Analysis of Key Enzyme Gene CoGPPS Involved in Iridoid Glycoside Synthesis in Cornus officinalis [0.03%]
杠柳长春藤苷合成关键酶基因CoGPPS的克隆及其表达分析
Jiaxi Chen,Xinjie Tan,Guangyang Guo et al.
Jiaxi Chen et al.
Cornus iridoid glycosides (CIGs), including loganin and morroniside, are the main active components of Cornus officinalis. As one of the key enzymes in the biosynthesis of CIGs, geranyl pyrophosphate synthase (GPPS) catalyzes the formation ...
The Role of Complement Component C3 in Protection Against Pseudomonas Pneumonia-Induced Lung Injury [0.03%]
补体成分C3在抵抗铜绿假单胞菌肺炎诱导的肺损伤中的作用
Sanjaya K Sahu,Rahul K Maurya,Hrishikesh S Kulkarni
Sanjaya K Sahu
The complement system is a family of proteins that facilitate immune resistance by attacking microbes to decrease pathogen burden. As a result, deficiencies of certain complement proteins result in recurrent bacterial infections, and can al...
Jacob G Malone,Catriona M A Thompson
Jacob G Malone
Exosomes Derived from Quercetin-Treated Bone Marrow Derived Mesenchymal Stem Cells Inhibit the Progression of Osteoarthritis Through Delivering miR-124-3p to Chondrocytes [0.03%]
槲皮素处理的骨髓间充质干细胞来源的外泌体通过向软骨细胞传递miR-124-3p来抑制骨关节炎的发展过程
Shiyu Dong,Genrong Xu,Xiaoliang Li et al.
Shiyu Dong et al.
Osteoarthritis (OA) is a chronic disease characterized by the progressive loss of cartilage and failure of the diarrheal joint. Quercetin has been reported to attenuate the development of OA. Bone marrow derived mesenchymal stem cell (BMSC)...
SHCBP1 Overexpression Aggravates Pancreatitis by Triggering the Loss of Primary Cilia [0.03%]
SHCBP1过表达通过引发原纤毛丧失而加重胰腺炎
Lianshun Li,Huiming Zhao,Zhengyang Li et al.
Lianshun Li et al.
Primary cilia are microtubule-based organelles that mediate various biological processes. Pancreatic cells are typically ciliated; however, the role of primary cilia in acute pancreatitis (AP) is largely unknown. Here, we report that the lo...
Molecular and Functional Characterization of Human Sex-Determining Region on the Y Chromosome Variants Using Protamine 1 Promoter [0.03%]
利用精子蛋白1启动子对人类Y染色体性别决定区变异的分子和功能特性进行鉴定
Deepali Pathak,Arka Baksi,S S Vasan et al.
Deepali Pathak et al.
The male sex-determining gene, sex-determining region on the Y chromosome (SRY), is expressed in adult testicular germ cells; however, its role in regulating spermatogenesis remains unclear. The role of SRY in the postmeiotic gene expressio...
Lyu-Ye Liu,Si-Jia He,Zhao Chen et al.
Lyu-Ye Liu et al.
Vitiligo is one of the common chronic autoimmune skin diseases in clinic, which is characterized by localized or generalized depigmentation and seriously affects the physical and mental health of patients. At present, the pathogenesis of vi...
Regulation of Cellular-Signaling Pathways by Mammalian Proteins Containing Bacterial EPIYA or EPIYA-Like Motifs Predicted to be Phosphorylated [0.03%]
含有预测被磷酸化的细菌EPIYA序列或类似序列的哺乳动物蛋白对细胞信号通路的调控
Mohammad Rasouli,Fatemeh Safari,Navid Sobhani et al.
Mohammad Rasouli et al.
The effector proteins of several pathogenic bacteria contain the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif or other similar motifs. The EPIYA motif is delivered into the host cells by type III and IV secretion systems, through which its tyrosine re...
Preparing for the Next Pandemic: Increased Expression of Interferon-Stimulated Genes After Local Administration of Nasalferon or HeberNasvac [0.03%]
下一代大流行病的准备：鼻用Nasferin或HeberNasvac后干扰素刺激基因表达增强
Jorge Agustín Aguiar Santiago,Maria Acelia Marrero Miragaya,Dariel Adrian Figueroa Oliva et al.
Jorge Agustín Aguiar Santiago et al.
HeberNasvac, a therapeutic vaccine for chronic hepatitis B, is able to safely stimulate multiple Toll-like receptors, increasing antigen presentation in vitro and in a phase II clinical trial (Profira) in elderly volunteers who were househo...