A Comprehensive Study on the Distribution of Integrons and Their Gene Cassettes in Clinical Isolates [0.03%]
类杆菌基因岛和可移动基因盒的分布及耐药性分析
Fatemeh Sarina Abdinia,Kasra Javadi,Mehdi Rajabnia et al.
Fatemeh Sarina Abdinia et al.
Antibiotic resistance is a significant global health concern, leading to increased morbidity, mortality, and health care costs. Integrons are genetic elements that could acquire and express gene cassettes, including those that confer antibi...
MiRNA Regulates Ferroptosis in Cardiovascular and Cerebrovascular Diseases [0.03%]
microRNA在心血管和脑血管疾病中的铁死亡调节作用
Yiman Liu,Peijuan Yang,Jingjing Wang et al.
Yiman Liu et al.
Cardiovascular and cerebrovascular diseases (CCVDs) significantly contribute to global mortality and morbidity due to their complex pathogenesis involving multiple biological processes. Ferroptosis is an important physiological process in C...
SNORA71A Downregulation Enhances Gemcitabine Sensitivity in Gallbladder Cancer Cells by Inducing Ferroptosis Through Inhibiting the AKT/NRF2/GPX4 Pathway [0.03%]
SNORA71A下调通过抑制AKT/NRF2/GPX4通路诱导铁死亡从而增强胆囊癌细胞对吉西他滨敏感性
Yiyu Qin,Yang Zhou,Hongyan Wu et al.
Yiyu Qin et al.
Previous findings have indicated a marked upregulation of SNORA71A in gallbladder cancer (GBC) tissues compared to normal samples. However, the precise role and molecular mechanisms of SNORA71A in GBC remain largely unknown. Moreover, gemci...
Radiation-Induced Intestinal Injury: Molecular Mechanisms and Therapeutic Status [0.03%]
辐射诱导肠损伤：分子机制和治疗现状
Dandan Gao,Heng Zhang,Wanjun Sun et al.
Dandan Gao et al.
Radiation-induced intestinal injury is one of the most common intestinal complications caused by pelvic and abdominal tumor radiotherapy, severely impacting patients' quality of life. Ionizing radiation, while killing tumor cells, inevitabl...
Isoorientin Alleviates DSS-Treated Acute Colitis in Mice by Regulating Intestinal Epithelial P-Glycoprotein (P-gp) Expression [0.03%]
异荭草素通过调节肠上皮P-糖蛋白的表达缓解DSS诱导的小鼠急性结肠炎
Zhenzhen Wang,Lanzhu Yang,Yun Feng et al.
Zhenzhen Wang et al.
Isoorientin (ISO) is a naturally occurring flavonoid with diverse functional properties that mitigate the risk of diseases stemming from oxidation, inflammation, and cancer cell proliferation. P-glycoprotein (P-gp) is a vital component of t...
EIF4A3-Induced Upregulation of hsa_circ_0049396 Attenuates the Tumorigenesis of Nasopharyngeal Carcinoma by Regulating the Hippo-YAP Pathway [0.03%]
EIF4A3通过调节Hippo-YAP信号通路诱导hsa_circ_0049396上调以抑制鼻咽癌肿瘤发生发展
Qi Zhou,Binlin Cai,Kun Liu et al.
Qi Zhou et al.
Circular RNAs (circRNAs) and eukaryotic translation initiation factor 4A3 (EIF4A3) have been reported to participate in the pathogenesis of nasopharyngeal carcinoma (NPC), but their mechanism has not been fully understood. This research aim...
Bone Marrow Mesenchymal Stem Cells-Derived Extracellular Vesicle miR-208a-3p Alleviating Spinal Cord Injury via Regulating the Biological Function of Spinal Cord Neurons [0.03%]
骨髓间充质干细胞来源的外泌体miR-208a-3p通过调节脊髓神经元的生物学功能缓解脊髓损伤
Jianwei Yang,Yanhua Yao
Jianwei Yang
We aim to explore the potential mechanism of bone marrow mesenchymal stem cells-derived extracellular vesicles (BMSCs-Exo) in improving spinal cord injury (SCI). Thirty male 12-week specific pathogen-free (SPF) Sprague-Dawley (SD) rats were...
Histidine Kinase QseC in Glaesserella parasuis Enhances the Secretion of Proinflammatory Cytokines by Macrophages via the p38 and NF-κB Signaling Pathways [0.03%]
禽葡萄球菌素 Parasuis 中组氨酸激酶 QseC 通过 p38 和 NF-κB 信号途径增强巨噬细胞促炎症细胞因子的分泌
Xuefeng Yan,Congwei Gu,Zehui Yu et al.
Xuefeng Yan et al.
The qseC gene is a two-component system that encodes a histidine protein kinase and is highly conserved among different Glaesserella parasuis strains. In this study, we used qRT-PCR and enzyme-linked immunosorbent assay to confirm that Toll...
Synaptotagmin 13 Could Drive the Progression of Esophageal Squamous Cell Carcinoma Through Upregulating ACRV1 [0.03%]
突触糖蛋白synaptotagmin 13通过上调ACRV1驱动食管鳞癌进展的新机制研究
Longlong Shao,Bin Li
Longlong Shao
SYT13 is one of the atypical members of the synaptotagmin (SYT) family whose function has attracted considerable attention in recent years. Although SYT13 has been studied in several types of human cancers, such as lung cancer, its role in ...
Innovating Cancer Treatment Through Cell Cycle, Telomerase, Angiogenesis, and Metastasis [0.03%]
通过细胞周期、端粒酶、新生血管和转移创新癌症治疗方案
Tooba Yousefi,Bahareh Mohammadi Jobani,Reyhaneh Taebi et al.
Tooba Yousefi et al.
Cancer remains a formidable challenge in the field of medicine, necessitating innovative therapeutic strategies to combat its relentless progression. The cell cycle, a tightly regulated process governing cell growth and division, plays a pi...