Pyruvate Kinase M2 Modulates the Glycolysis of Chondrocyte and Extracellular Matrix in Osteoarthritis [0.03%]
丙酮酸激酶M2在骨关节炎中调节软骨细胞糖酵解及细胞外基质合成中的作用研究
Xiaobo Yang,Weiping Chen,Xiang Zhao et al.
Xiaobo Yang et al.
Pyruvate kinase M2 (PKM2) has been wildly verified to modulate glycolysis in tumor cells. However, the role of PKM2 on the glycolysis of osteoarthritis (OA) chondrocytes is still unclear. In present study, we investigate the function of PKM...
Linya Wang,Jing-Hsiung James Ou
Linya Wang
Macroautophagy, hereafter autophagy, is a catabolic process that is important for maintaining cellular homeostasis. It can also be used by cells to remove intracellular microbial pathogens. However, the studies on hepatitis C virus (HCV) in...
Changes in Body Mass Index, Leptin, and Leptin Receptor Polymorphisms and Breast Cancer Risk [0.03%]
体质指数、瘦素及瘦素受体多态性的改变与乳腺癌风险的关系
Chun-Rong Liu,Qin Li,Can Hou et al.
Chun-Rong Liu et al.
Obesity is a strong risk factor for breast cancer. The polymorphisms of leptin (LEP) and leptin receptor (LEPR) may be associated with breast cancer by regulator of adipose tissue mass and tumor cell growth. A total of 794 cases and 805 mat...
Posttranscriptional Regulation of Human Antigen R by miR-133b Enhances Docetaxel Cytotoxicity Through the Inhibition of ATP-Binding Cassette Subfamily G Member 2 in Prostate Cancer Cells [0.03%]
人源性抗原R由miR-133b进行产后转录调控通过抑制ATP结合盒子G成员2在前列腺癌细胞中增强多西他赛的毒性
Hui Liu,Xiaolong Song,Junqing Hou et al.
Hui Liu et al.
Docetaxel (DTX)-based chemotherapy is a first-line therapy in patients with castration-resistant prostate cancer. However, development of DTX resistance remains a challenge in cancer treatment. miRNAs have been shown to be involved in drug ...
Glaucocalyxin A Attenuates the Activation of Hepatic Stellate Cells Through the TGF-β1/Smad Signaling Pathway [0.03%]
金丝桃苷通过TGF-β1/Smads信号途径抑制肝星状细胞活化
Zhichao Dong,Qi Gao,Hao Guo
Zhichao Dong
Glaucocalyxin A (GLA) is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx. A large number of studies have shown that GLA possesses important pharmacological activities, such as anti-inflammato...
Functional Defects of Regulatory T Cell Through Interleukin 10 Mediated Mechanism in the Induction of Gestational Diabetes Mellitus [0.03%]
通过介导妊娠糖尿病发病的细胞因子白细胞介素10探讨调节性T细胞功能异常
Yan Yang,Lixiu Liu,Beibei Liu et al.
Yan Yang et al.
Gestational diabetes mellitus (GDM) is a metabolic and low-grade inflammatory disease most commonly found in pregnant women with high body mass index and non-Caucasian ethnicities; however, not all women of high-risk groups develop GDM. We ...
Long Noncoding RNA EBF3-AS Promotes Neuron Apoptosis in Alzheimer's Disease [0.03%]
长链非编码RNA EBF3-AS促进阿尔茨海默病中的神经元凋亡
Cheng Gu,Cheng Chen,Ruipeng Wu et al.
Cheng Gu et al.
Alzheimer's disease (AD) is the most common form of dementia; its pathophysiological mechanism remains unclear. Long noncoding RNAs (lncRNAs) play key roles in AD. lncRNA EBF3-AS has been found dysregulated in AD, which is abundantly expres...
A Rare Rs139365823 Polymorphism in Pre-miR-138 Is Associated with Risk of Congenital Heart Disease in a Chinese Population [0.03%]
中国人群极少见的rs139365823多态性与先天性心脏病易感性的关联研究
Xiaobo Gao,Liping Yang,Haiyan Luo et al.
Xiaobo Gao et al.
miR-138 modulates cardiac morphogenesis in zebrafish. We explored whether a genetic polymorphism in miR-138 might contribute to the occurrence of sporadic congenital heart disease (CHD) and the potential mechanism. We performed a case-contr...
Quantitative Evaluation of MMP-9 and TIMP-1 Promoter Methylation in Chronic Periodontitis [0.03%]
慢性牙周炎患者MMP-9和TIMP-1启动子甲基化的定量研究
Xiting Li,Jiaxuan Lu,Wei Teng et al.
Xiting Li et al.
In this study, we investigated the promoter DNA methylation (DNAm) status of the MMP-9 and TIMP-1 genes in patients with chronic periodontitis to evaluate disease progression. Using pyrosequencing technology, DNAm levels of MMP-9 and TIMP-1...
Michaela J Schultz,John H Connor,Horacio M Frydman
Michaela J Schultz
Mosquito-borne viruses, including Zika virus (ZIKV) and dengue virus (DENV), are global threats that continue to infect millions annually. Historically, efforts to combat the spread of these diseases have sought to eradicate the mosquito po...