Long Noncoding RNA EBF3-AS Promotes Neuron Apoptosis in Alzheimer's Disease [0.03%]
长链非编码RNA EBF3-AS促进阿尔茨海默病中的神经元凋亡
Cheng Gu,Cheng Chen,Ruipeng Wu et al.
Cheng Gu et al.
Alzheimer's disease (AD) is the most common form of dementia; its pathophysiological mechanism remains unclear. Long noncoding RNAs (lncRNAs) play key roles in AD. lncRNA EBF3-AS has been found dysregulated in AD, which is abundantly expres...
A Rare Rs139365823 Polymorphism in Pre-miR-138 Is Associated with Risk of Congenital Heart Disease in a Chinese Population [0.03%]
中国人群极少见的rs139365823多态性与先天性心脏病易感性的关联研究
Xiaobo Gao,Liping Yang,Haiyan Luo et al.
Xiaobo Gao et al.
miR-138 modulates cardiac morphogenesis in zebrafish. We explored whether a genetic polymorphism in miR-138 might contribute to the occurrence of sporadic congenital heart disease (CHD) and the potential mechanism. We performed a case-contr...
Quantitative Evaluation of MMP-9 and TIMP-1 Promoter Methylation in Chronic Periodontitis [0.03%]
慢性牙周炎患者MMP-9和TIMP-1启动子甲基化的定量研究
Xiting Li,Jiaxuan Lu,Wei Teng et al.
Xiting Li et al.
In this study, we investigated the promoter DNA methylation (DNAm) status of the MMP-9 and TIMP-1 genes in patients with chronic periodontitis to evaluate disease progression. Using pyrosequencing technology, DNAm levels of MMP-9 and TIMP-1...
Michaela J Schultz,John H Connor,Horacio M Frydman
Michaela J Schultz
Mosquito-borne viruses, including Zika virus (ZIKV) and dengue virus (DENV), are global threats that continue to infect millions annually. Historically, efforts to combat the spread of these diseases have sought to eradicate the mosquito po...
SOX7 Suppresses Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction [0.03%]
SOX7通过干扰β-连环蛋白/BCL9相互作用抑制Wnt信号通路
Rong Fan,HaiYan He,Wang Yao et al.
Rong Fan et al.
The Wnt signaling is involved in angiogenesis and tumor development. β-catenin is the core component of the Wnt pathway, which mediates oncogenic transcription and regulated by a series of proteins. Sex-determining region Y-box 7 (SOX7) is...
Clinical Applications of and Challenges in Single-Cell Analysis of Circulating Tumor Cells [0.03%]
循环肿瘤细胞单细胞分析的临床应用和挑战
Chang-Peng Wu,Peng Wu,Hua-Fu Zhao et al.
Chang-Peng Wu et al.
Technological advancements in next-generation sequencing are continually changing the landscape of genomic, transcriptomic, and epigenetic research at the single-cell level. These technologies have been used to detect and analyze circulatin...
Flaviviruses Produce a Subgenomic Flaviviral RNA That Enhances Mosquito Transmission [0.03%]
黄病毒产生的一种亚基因组黄病毒RNA可增强蚊虫传播能力
Shih-Chia Yeh,Julien Pompon
Shih-Chia Yeh
Mosquito-borne flaviviruses (MBFVs) are a global public health burden. MBFVs have several unique 3'UTR structures that inhibit the host RNA decay machinery to produce subgenomic flaviviral RNAs (sfRNAs). Number of sfRNA species and their re...
Comprehensive Analysis of Gene Expression Profiles of Sepsis-Induced Multiorgan Failure Identified Its Valuable Biomarkers [0.03%]
脓毒症诱导的多器官功能障碍基因表达谱的全面分析及其生物标志物价值评估
Yumei Wang,Xiaoling Yin,Fang Yang
Yumei Wang
Sepsis is an inflammatory-related disease, and severe sepsis would induce multiorgan dysfunction, which is the most common cause of death of patients in noncoronary intensive care units. Progression of novel therapeutic strategies has prove...
Genome-Wide Analysis of Uveal Melanoma Metastasis-Associated LncRNAs and Their Functional Network [0.03%]
转移相关的虹膜黑色素瘤长链非编码RNA及其功能网络的全基因组分析
Binbin Xu,Ruiqi Ma,Hui Ren et al.
Binbin Xu et al.
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Up to 50% of primary UM cases will develop distant metastasis, but no effective therapies are currently available. The present study aimed to characterize the ...
miR-19-5p Enhances Tumorigenesis in Human Colorectal Cancer Cells by Targeting TSPYL5 [0.03%]
microRNA-19-5p通过靶向TSPYL5促进人类结直肠癌细胞肿瘤发生
Chao Huang,Hesheng Luo
Chao Huang
The cancer suppressor gene, testis-specific protein Y-encoded-like 5 (TSPYL5), has been implicated in various cancers, including colorectal cancer (CRC). In this study, we investigated the role of TSPYL5 in the development of CRC in vitro. ...