Exosome-Delivered Hsa_Circ_0000116 Facilitates Osteosarcoma Cell Malignancy via PI3K/Akt/mTOR and p38/MAPK Pathways [0.03%]
外泌体递送的Hsa_circ_0000116通过PI3K/Akt/mTOR和p38/MAPK途径促进成骨肉瘤细胞恶性表型
Chunsheng Gao,Xiaowei Wang,Huichao Yan et al.
Chunsheng Gao et al.
Exosome-delivered circular RNAs (circRNAs) are recognized as a key mechanism that regulates osteosarcoma (OS) progression. The purpose of this study is to discover the role of a novel circRNA hsa_circ_0000116 from exosomes in OS progression...
Pirfenidone Downregulates eIF6, P311, and TGF-β Expression and Improves Liver Fibrosis Induced by Bile Duct Ligation in Wistar Rats: Evidence for Liver Regeneration [0.03%]
Pirfenidone通过下调eIF6、P311和TGF-β的表达改善Wistar大鼠胆管结扎诱导的肝纤维化：肝脏再生的证据
Zeynab Yousefi,Mitra Nourbakhsh,Abbas Sahebghadam Lotfi
Zeynab Yousefi
Liver fibrosis (LF) is a clinical disorder characterized by inflammation and excessive accumulation of extracellular matrix (ECM). This study investigates the effects of the antifibrotic compound pirfenidone (PFD) on improving LF through hi...
The Interplay Between Obesity and Aging in Breast Cancer and Regulatory Function of MicroRNAs in This Pathway [0.03%]
肥胖和衰老在乳腺癌中的相互作用及微小RNA在此途径中的调节功能
Nima Mahdei Nasir Mahalleh,Mina Hemmati,Arezou Biyabani et al.
Nima Mahdei Nasir Mahalleh et al.
Breast cancer (BC) is a significant contributor to cancer-related deaths in women, and it has complex connections with obesity and aging. This review explores the interaction between obesity and aging in relation to the development and prog...
METTL3-Induced m6A Modification Enhances Hsa_Circ_0136959 Expression to Impair the Tumor Characteristics of Papillary Thyroid Carcinoma via Accelerating Ferroptosis [0.03%]
METTL3诱导的m6A修饰通过促进铁死亡以增强环状RNA hsa_circ_0136959表达从而抑制乳头状甲状腺癌恶性表型的作用及机制研究
Lan Luo,Yanlei Sun,Zongli Cao
Lan Luo
The number of cases of papillary thyroid cancer (PTC) has gone up significantly in recent years, with high recurrence. Numerous reports have highlighted the participation of circular RNAs (circRNAs) in regulating the advancement of cancers,...
Identification and Analysis of Autophagy-Related Genes as Diagnostic Markers and Potential Therapeutic Targets for Tuberculosis Through Bioinformatics [0.03%]
基于生物信息学的结核病诊断标志物及潜在治疗靶点的鉴定与分析（自噬相关基因）
Tingting Luo,Shijie Shen,Yufei Sun et al.
Tingting Luo et al.
According to the World Health Organization, Mycobacterium tuberculosis infections affect approximately 25% of the world's population. There is mounting evidence linking autophagy and immunological dysregulation to tuberculosis (TB). As a re...
Inherited Spinocerebellar Ataxia Segregates with Intra-Familial Genetic Heterogeneity in a Consanguineous Pakistani Family: A Report of a Potential Novel Candidate Gene [0.03%]
一个近亲婚配的巴基斯坦家庭遗传性脊小脑共济失调基因型和表型异质性的研究报告：潜在新候选基因报告
Yaqi Zhou,Jun Xu,Muhammad Asif et al.
Yaqi Zhou et al.
Hereditary spinocerebellar ataxia (SCA) is a group of genetic neurodegenerative disorders caused by a variety of gene variants. At least 44 types of SCAs have been identified to date, and more than 35 genes and hundreds of variants have bee...
A Long-Term Follow-Up Study of Serum NFATc3 Levels in Pediatric Patients with Bronchial Asthma: A Prospective Observational Case-Control Investigation [0.03%]
儿童哮喘患者血清NFATc3长期随访研究：前瞻性队列病例对照研究
Xi Zhang,Xiaojun Duan,Yuan Chen et al.
Xi Zhang et al.
The early and precise diagnosis of asthma significantly impacts the long-term health outcomes of pediatric patients. The sensitivity and specificity of current biomarkers, however, are frequently limited. Our study aimed to evaluate the cli...
Histone Lactylation-Driven GPD2 Mediates M2 Macrophage Polarization to Promote Malignant Transformation of Cervical Cancer Progression [0.03%]
组蛋白乳酰化驱动的GPD2介导M2型巨噬细胞极化促进宫颈癌恶性转化及进展
Chenlingzi Huang,Lujiadai Xue,Xinzi Lin et al.
Chenlingzi Huang et al.
Cervical cancer (CC) is the most common cancer in women. This study aims to explore the molecular mechanism of lactate secreted by CC cells modulating macrophage polarization in CC via histone lactylation. Normal cervical epithelium (NCE), ...
The Role of lncRNA FEZF1-AS1 in Colorectal Cancer Progression Via the P53 Signaling Pathway [0.03%]
长链非编码RNA FEZF1-AS1通过p53信号通路在结直肠癌进展中的作用研究
Minglu Ding,Wanyao Wang,Keyuan Huo et al.
Minglu Ding et al.
Long noncoding RNAs (lncRNAs) have emerged as critical regulators in the development of colorectal cancer (CRC). Previous studies indicate that lncRNA FEZF1-AS1 is highly expressed in CRC, but its role in modulating CRC via the P53 signalin...
Association Study of rs1632947, rs1233334, and rs371194629 Polymorphisms in Human Leukocyte Antigen G Gene Expression and soluble Human Leukocyte Antigen G with Lupus [0.03%]
HLA-G基因多态性、表达及其可溶性形式与系统性红斑狼疮的相关研究
Kamil Mahdi Halboot Aljumaili,Mehdi Haghi,Mohammad Khalaj Kondori et al.
Kamil Mahdi Halboot Aljumaili et al.
Systemic lupus erythematosus is a chronic autoimmune disease that has been associated with human leukocyte antigen G (HLA-G) in previous studies on immunological diseases. This study aimed to investigate the association between three HLA-G ...