A Long-Term Follow-Up Study of Serum NFATc3 Levels in Pediatric Patients with Bronchial Asthma: A Prospective Observational Case-Control Investigation [0.03%]
儿童哮喘患者血清NFATc3长期随访研究：前瞻性队列病例对照研究
Xi Zhang,Xiaojun Duan,Yuan Chen et al.
Xi Zhang et al.
The early and precise diagnosis of asthma significantly impacts the long-term health outcomes of pediatric patients. The sensitivity and specificity of current biomarkers, however, are frequently limited. Our study aimed to evaluate the cli...
Histone Lactylation-Driven GPD2 Mediates M2 Macrophage Polarization to Promote Malignant Transformation of Cervical Cancer Progression [0.03%]
组蛋白乳酰化驱动的GPD2介导M2型巨噬细胞极化促进宫颈癌恶性转化及进展
Chenlingzi Huang,Lujiadai Xue,Xinzi Lin et al.
Chenlingzi Huang et al.
Cervical cancer (CC) is the most common cancer in women. This study aims to explore the molecular mechanism of lactate secreted by CC cells modulating macrophage polarization in CC via histone lactylation. Normal cervical epithelium (NCE), ...
The Role of lncRNA FEZF1-AS1 in Colorectal Cancer Progression Via the P53 Signaling Pathway [0.03%]
长链非编码RNA FEZF1-AS1通过p53信号通路在结直肠癌进展中的作用研究
Minglu Ding,Wanyao Wang,Keyuan Huo et al.
Minglu Ding et al.
Long noncoding RNAs (lncRNAs) have emerged as critical regulators in the development of colorectal cancer (CRC). Previous studies indicate that lncRNA FEZF1-AS1 is highly expressed in CRC, but its role in modulating CRC via the P53 signalin...
Association Study of rs1632947, rs1233334, and rs371194629 Polymorphisms in Human Leukocyte Antigen G Gene Expression and soluble Human Leukocyte Antigen G with Lupus [0.03%]
HLA-G基因多态性、表达及其可溶性形式与系统性红斑狼疮的相关研究
Kamil Mahdi Halboot Aljumaili,Mehdi Haghi,Mohammad Khalaj Kondori et al.
Kamil Mahdi Halboot Aljumaili et al.
Systemic lupus erythematosus is a chronic autoimmune disease that has been associated with human leukocyte antigen G (HLA-G) in previous studies on immunological diseases. This study aimed to investigate the association between three HLA-G ...
Etomidate Inhibits Hepatic Ischemia-Reperfusion Injury Depending on the Activation of Nrf2-HO-1 Signaling Pathway [0.03%]
依托咪酯通过激活Nrf2-HO-1信号通路抑制肝脏缺血再灌注损伤
Huajing Shan,Zhifang Wang,Yun Chen et al.
Huajing Shan et al.
Hepatic ischemia-reperfusion (I/R) injury (HIRI) is recognized as a local aseptic inflammatory response driven by innate immunity and is considered a leading cause of early organ dysfunction and failure following liver transplantation. Etom...
Magnesium Lithospermate B Inhibits Colorectal Cancer Cell Progression Through JAK2-STAT3 Signaling [0.03%]
丹参素B通过JAK2-STAT3信号抑制结直肠癌细胞进展
Dan Huo,Jinpeng Zhang,Tengfei Ma et al.
Dan Huo et al.
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide. The discovery of new effective therapeutic drugs is always a priority. Magnesium lithospermate B (MLB), a native pol...
Uncovering ASO-Targetable Deep Intronic AIRE Variants: Insights and Therapeutic Implications [0.03%]
揭示可靶向ASO的深层内含子AIRE变异：见解与治疗意义
Sebastian Ochoa,Michail S Lionakis
Sebastian Ochoa
High-throughput DNA sequencing has accelerated the discovery of disease-causing genetic variants, yet only in 10-40% of cases yield a genetic diagnosis. Increased implementation of genome sequencing has enabled a deeper exploration of the n...
Kenneth Rubio-Carrasco,Paola García de la Torre,José D Martínez-Ezquerro et al.
Kenneth Rubio-Carrasco et al.
Hypertension is the leading risk for cardiovascular disease and worldwide mortality. Uncontrolled blood pressure worsens with age and its control is part of public health strategies especially for older adults. Telomere length (TL) has been...
Reza Shah Hosseini,Seyed Mohammad Nouri,Pooja Bansal et al.
Reza Shah Hosseini et al.
One of the main health issues in the modern world is cancer, with breast cancer (BC) as one of the most common types of malignancies. Different environmental and genetic risk factors are involved in the development of BC. One of the primary...
Impact of Chondroitin Sulfate Proteoglycan 4 Pseudogene 12 Genetic Variants on Colorectal Cancer Risk: A Case-Control Study [0.03%]
软骨素硫酸蛋白聚糖4假基因12遗传变异体对结直肠癌风险影响的病例对照研究
Xianlei Zhou,Liwen Guo,Zhenbang Yang et al.
Xianlei Zhou et al.
This study aims to investigate the correlation between the chondroitin sulfate proteoglycan 4 pseudogene 12 (CSPG4P12) polymorphism and the risk of colorectal cancer (CRC). This case-control study involved 850 patients with CRC and 850 heal...