DNMT3B drives neuroendocrine lineage plasticity and aggressive progression in prostate cancer [0.03%]
DNA methyl转移酶3B驱动前列腺癌神经内分泌谱系的可塑性和侵袭性进展
Yunsol Jo,Hyeryeon Jung,Ziqin Wang et al.
Yunsol Jo et al.
Neuroendocrine prostate cancer (NEPC) is an aggressive and therapy-resistant subtype of advanced prostate cancer characterized by poor prognosis and limited treatment options. Enzalutamide, an androgen receptor (AR) pathway inhibitor, is a ...
The PON1-NDUFA4 axis maintains mitochondrial respiratory fitness and drives lenvatinib tolerance in hepatocellular carcinoma [0.03%]
PON1-NDUFA4轴维持线粒体呼吸功能并驱动肝细胞癌对仑伐替尼的耐受性
Shi-Lin Lin,Yue Wang,Yi-Min Zheng et al.
Shi-Lin Lin et al.
Metabolic plasticity driven by mitochondrial oxidative phosphorylation (OXPHOS) is increasingly recognized as a key determinant of therapeutic tolerance in hepatocellular carcinoma (HCC), but the upstream regulators that preserve electron t...
3beta-HSD1-mediated steroid back-conversion maintains androgen signaling in prostate cancer [0.03%]
3β-羟基类固醇脱氢酶介导的固醇反向转化维持前列腺癌中的雄激素信号传导
Masoud Bitaraf,Mohammad Alyamani,Nikou Fotouhi et al.
Masoud Bitaraf et al.
Dihydrotestosterone (DHT), the principal driver of prostate cancer, is inactivated via reduction of its 3-keto group to a 3β-hydroxyl (3β-OH). 3β-Hydroxysteroid dehydrogenase type 1 (3β-HSD1), encoded by HSD3B1, catalyzes 3β-OH oxidati...
COL1A1-Mediated Bmp1/Tgf-β Signaling Augments EMT and M2 Macrophage Polarization in Oral Squamous Cell Carcinoma [0.03%]
COL1A1介导的Bmp1/TGF-β信号通过上皮间质转化和M2型巨噬细胞极化促进口腔鳞状细胞癌进展
Xing Liu,Yalun Li,Lanlan Gao et al.
Xing Liu et al.
Oral squamous cell carcinoma (OSCC) is a lethal malignancy characterized by frequent metastasis. Utilizing a 4-NQO-induced murine model and single-cell RNA sequencing, we identified a distinct Collagen Type I Alpha 1 Chain (Col1a1+) epithel...
ERG orchestrates a dedifferentiation-senescence-inflammation triad in prostate cancer [0.03%]
ERG调控前列腺癌去分化-衰老-炎症三联征
Francesca Lorenzin,Giulia Fracassi,Federico Vannuccini et al.
Francesca Lorenzin et al.
ERG fusions occur in about 50% of prostate cancers (PCa) and represent early somatic events that co-initiate tumorigenesis. Yet, the molecular programs unleashed by ERG at disease onset remain elusive. Here, the inducible, temporally contro...
Comprehensive multi-omic profiling of desmoplastic small round cell tumors identifies targetable pathways with therapeutic opportunities [0.03%]
全面的多组学谱描绘底膜细胞瘤并鉴定可靶向的途径及潜在治疗策略
Jamie M Keck,Limin Zhu,Jayne M Stommel et al.
Jamie M Keck et al.
Desmoplastic small round cell tumors (DSRCTs) are rare, aggressive, fusion-driven sarcomas with poor outcomes despite intensive chemotherapy. Utilization of targeted therapies in DSRCT remains limited, underscoring the need for deeper chara...
CELF2 is a tumor suppressor that modulates SLC7A11 and promotes ferroptosis in stomach adenocarcinoma [0.03%]
CELF2通过调控SLC7A11促进胃腺癌细胞铁死亡发生的新功能研究
Shoucai Zhang,Shichao Liu,Zeyu Zhang et al.
Shoucai Zhang et al.
Stomach adenocarcinoma (STAD) is among the most prevalent malignant gastrointestinal tumors worldwide. Ferroptosis, a relatively new form of programmed cell death, has garnered significant attention for its role in cancer molecular mechanis...
MYC-Mediated USP39 Upregulation Stabilizes SRSF1 in Pancreatic Cancer [0.03%]
MYC通过USP39上调稳定SRSF1在胰腺癌中的作用
Benteng Ma,Xin Zhang,Alexander J Kral et al.
Benteng Ma et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy primarily driven by oncogenic KRAS signaling. The splicing factor SRSF1 plays a key oncogenic role in PDAC through reciprocal cross-interactions with KRAS signaling. Howe...
Ceramide-induced endoplasmic reticulum stress reveals a targetable vulnerability in endocrine therapy-resistant breast cancer [0.03%]
鞘氨醇诱导的内质网压力揭示了内分泌治疗耐药乳腺癌的可靶向弱点
Purab Pal,Shweta Chitkara,Godwin K Sarpey et al.
Purab Pal et al.
Despite the success of endocrine therapy (ET) in treating hormone receptor-positive breast cancer, a significant proportion of patients relapse during or after treatment, making ET resistance a major clinical challenge. Previously we have s...
Mapping the Subtype-Specific PARP1 ADP-ribosylated Proteome in Breast Cancer Cells [0.03%]
绘制乳腺癌细胞中PARP1亚型特异性ADP-核糖基化蛋白组图谱
Sneh Koul,Minjung Kwon,Poulami Tapadar et al.
Sneh Koul et al.
Breast cancers are molecularly heterogeneous, with subtype-specific differences in transcriptional programs, chromatin architecture, and therapeutic responses. While PARP1 has been extensively studied in the context of DNA repair, emerging ...