Protective Effect of HMG-CoA Reductase Inhibitor Rosuvastatin on Doxorubicin-Induced Cognitive Impairment, Oxidative Stress and Neuroinflammation: Possible Role of CREB, ERK1/2, and BDNF [0.03%]
HMG-CoA还原酶抑制剂Rosuvastatin对多柔比星致认知障碍、氧化应激及神经炎症的保护作用及其可能的作用机制CREB，ERK1/2和BDNF的影响
Yesim Yeni,Betul Cicek,Ahmet Hacimuftuoglu et al.
Yesim Yeni et al.
During or after chemotherapy, cognitive impairments characterized by forgetfulness, difficulty concentrating, and depressive and anxiety-like symptoms are observed. There is limited research examining the effects of rosuvastatin (RVS), an H...
Lycopene Supplemented Mediterranean Diet Ameliorates Experimental Autoimmune Encephalomyelitis (EAE) in Mice and Changes Intestinal Microbiome [0.03%]
番茄红素补充的地中海饮食可缓解小鼠实验性自身免疫性脑脊髓炎并改变肠道微生物群
Tutku Atuk Kahraman,Müge Yılmaz,Kübra Aslan et al.
Tutku Atuk Kahraman et al.
This study aimed to determine the effects of the Mediterranean diet (MD) and lycopene on the development of EAE and on inflammatory markers. In the 43-day study, 72 female C57BL/6 mice were randomly divided into eight groups according to wh...
Exploring Anticonvulsant Effects of Pomalidomide by Targeting Oxidative Stress and Nrf2-Ho1 Signaling Pathway in Male Wistar Rats: A New Insight in Seizure Control [0.03%]
通过靶向氧化应激和Nrf2-Ho1信号通路探讨泊马度胺的抗惊厥作用：雄性Wistar大鼠中的新发现
Elnaz Khorasanian,Hassan Rajabi-Maham,Vahid Azizi et al.
Elnaz Khorasanian et al.
Current medications for seizure symptoms can reduce seizure severity but do not stop or slow their progression. These drugs often have unpleasant side effects and may not work for all patients. The search for new therapeutic targets for sei...
Unraveling the Immune Puzzle: Role of Immunomodulation in Alzheimer's Disease [0.03%]
解开免疫 puzzle：免疫调节在阿尔茨海默病中的作用
Ashvin,Rishika Dhapola,Sneha Kumari et al.
Ashvin et al.
Alzheimer's disease (AD) is a complex neurodegenerative disorder with growing evidence highlighting the dual role of immunomodulation in its pathogenesis and potential therapeutic strategies. Disturbance in the immune system increases the i...
Current Understanding of the Exosomes and Their Associated Biomolecules in the Glioblastoma Biology, Clinical Treatment, and Diagnosis [0.03%]
当前对胶质母细胞瘤生物学、临床治疗及诊断中 exosome及其相关生物分子的认识
Aghdas Ramezani,Maryam Rahnama,Fatemeh Mahmoudian et al.
Aghdas Ramezani et al.
Glioblastoma is the most common and aggressive brain tumor with a low survival rate. Due to its heterogeneous composition, high invasiveness, and frequent recurrence after surgery, treatment success has been limited. In addition, due to the...
Unmasking a Paradox: Roles of the PD-1/PD-L1 Axis in Alzheimer's Disease-Associated Neuroinflammation [0.03%]
破解悖论：PD-1 / PD-L1轴在阿尔茨海默病相关神经炎症中的作用
Ali Moadab,Hossein Khorramdelazad,Mohammad Taha Akbari Javar et al.
Ali Moadab et al.
Alzheimer's disease (AD) represents the most prevalent form of dementia, characterized by progressive cognitive impairment and chronic neuroinflammation. Immune checkpoint inhibitors (ICIs), including anti-programmed cell death (PD)-1 and a...
Human Umbilical Cord Mesenchymal Stem Cells Ameliorated Chronic Unpredictable Mild Stress-Induced Depression and Anxiety by Alleviating Neuroinflammation [0.03%]
人源脐带间充质干细胞通过减轻神经炎症缓解慢性不可预测轻度压力引起的抑郁和焦虑症状
Guangyang Liu,Li Miao,Haichen Niu et al.
Guangyang Liu et al.
Inflammation, neurotransmitters, and apoptotic neurons are crucial elements in the progression of Major Depressive Disorder (MDD). Previous studies have demonstrated that mesenchymal stem cells (MSCs) had a positive impact on neuroinflammat...
Cranberry Extract Ameliorates Diabetic Cognitive Impairment in Rats Via LncRNA GAS-5 Downregulation and Pyroptosis Pathway Inhibition [0.03%]
蔓越莓提取物通过下调长链非编码RNA GAS-5和抑制细胞焦亡通路改善大鼠糖尿病认知障碍
Mariam Ali Abo-Saif,Amany E Ragab,Iman M Talaat et al.
Mariam Ali Abo-Saif et al.
The pathophysiology of diabetes-induced brain injury involves pyroptosis, an inflammatory programmed cell death. This study aimed to investigate the potential protective effect of cranberry extract (CE) against diabetes-induced brain injury...
Novel Trajectories Towards Possible Effects of Semaglutide for Amelioration of Reserpine-induced Fibromyalgia in Rats: Contribution of cAMP/PKA/p-CREB and M1/M2 Microglia Polarization [0.03%]
司美格鲁肽改善降压药利舍平致大鼠纤维肌痛综合症的可能作用机制：cAMP/PKA/p-CREB信号通路和M1/M2小胶质细胞极化的影响
Mena Z Shafiek,Hala F Zaki,Ahmed F Mohamed et al.
Mena Z Shafiek et al.
Fibromyalgia (FM) is a pain disorder characterized by pervasive musculoskeletal pain associated with exhaustion, depression, and irregular sleep patterns. Semaglutide, an innovative glucagon-like peptide-1 (GLP-1) agonist, has shown analges...
The Role of Microglial Exosomes in Clozapine Treatment: Effect on Cognition in Schizophrenia [0.03%]
微小胶质细胞外泌体在氯氮平治疗中的作用：对精神分裂症认知的影响
Kyle Hewitt,Xu-Feng Huang
Kyle Hewitt
Schizophrenia is a complex neuropsychiatric disorder characterized by a spectrum of symptoms including cognitive impairments and psychotic episodes. Clozapine, an atypical antipsychotic drug, is a widely recognised treatment option for pati...