Vitamin D Promotes Neuronal Survival via Nrf2 Upregulation in D-Galactose-Induced Mice: An In-Vivo and In-Silico Study [0.03%]
维生素D通过Nrf2上调促进D-半乳糖诱导的小鼠神经元存活：体内和体外研究
Fawad Ali Shah,Muhammad Zakria,Faten F Bin Dayel et al.
Fawad Ali Shah et al.
Gradual loss of the homeostatic balance owing to deregulation of endogenous antioxidant defense pathways, such as nuclear factor erythroid 2-related factor 2 (Nrf2), contributes, at least in part, to the characteristic oxidative stress, neu...
Targeting IL-33 in Precision Neuroimmunology: Cellular Mechanisms and Therapeutic Strategies for CNS Disorders [0.03%]
靶向神经免疫学中的IL-33：中枢神经系统疾病细胞机制和治疗策略精确神经免疫学中的IL-33靶向：中枢神经系统疾病的细胞机制和治疗策略
Lili Li,Shuting Wang,Lian Duan et al.
Lili Li et al.
Interleukin-33 (IL-33), an alarmin cytokine of the IL-1 family, has emerged as a pivotal regulator of neuroimmune interactions in the central nervous system (CNS). Acting through its receptor ST2, IL-33 orchestrates diverse immune responses...
Study on the Effects and Mechanisms of Resveratrol in Improving Cognitive Impairment in Aβ1-42-Induced Alzheimer's Disease Model Mice [0.03%]
白藜芦醇改善Aβ1-42诱导的阿尔茨海默病模型小鼠认知障碍的作用及机制研究
Chu Zhang,Yunhan Ma,Zhidan Shi et al.
Chu Zhang et al.
Aging is a major risk factor for neurodegenerative diseases, including Alzheimer's disease (AD). Targeting cellular senescence has therefore emerged as a promising therapeutic strategy. Resveratrol (RV), a natural polyphenolic compound, exh...
Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) Diminish CD16+ Monocyte-Induced Astrocyte Inflammation, while THC Uniquely Inhibits Monocyte Chemotaxis Independent of HIV Status [0.03%]
Δ9-四氢大麻酚（THC）和大麻二酚（CBD）可减轻CD16+单核细胞诱导的星形胶质细胞炎症，而THC可特异性抑制单核细胞趋化性，与HIV状态无关
Sera Sermet,Robert B Crawford,Peter Gulick et al.
Sera Sermet et al.
CD16+ monocytes are a minor subset of the total monocyte population that play a disproportionate role in contributing to neuroinflammation in human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND). This has been evide...
Neuroimmune Correlates of HIV and Marijuana Use: Peripheral Biomarkers and Cognitive Function [0.03%]
人类免疫缺陷病毒和大麻使用的神经免疫标志物及其对认知功能的影响
Michaela E Larson,E Alfonso Romero-Sandoval,Sheri L Towe et al.
Michaela E Larson et al.
People with HIV (PWH) exhibit persistent immune activation despite suppressive antiretroviral therapy, contributing to neurocognitive vulnerability. Marijuana use is common among PWH and may influence inflammatory pathways, but its in vivo ...
Therapeutic Effects of Zhilong Huoxue Tongyu Capsule on Oxidative Stress and Neuroprotection in a Rat Model of Intracerebral Hemorrhage [0.03%]
蛭龙活血通瘀胶囊对脑出血大鼠氧化应激及神经保护作用的影响研究
Lixia Wang,Guijin Zhu,Gang Luo et al.
Lixia Wang et al.
The purpose of this study is to investigate the mechanism of Zhilong Huoxue Tongyu (ZL) capsule on the treatment of intracerebral hemorrhage (ICH). In this study, ICH model was established to assess the neuroprotective efficacy of ZL capsul...
Zohre Eftekhari,Seyed Amir Sadeghi,Fatemeh Kazemi-Lomedasht
Zohre Eftekhari
Neuropeptide Y (NPY) is a highly conserved 36-amino acid neuropeptide broadly distributed throughout the central and peripheral nervous systems, where it classically regulates appetite, stress responses, and circadian rhythms. Increasing ev...
Natural Killer Cells: Dual Regulators and Therapeutic Targets in Multiple Sclerosis Immunopathogenesis [0.03%]
自然杀伤细胞：多发性硬化免疫病理发病中的双重调节者和治疗靶点
Maryam Vahdat Lasemi,Maryam Mehravar,Amirhossein Izadpanah et al.
Maryam Vahdat Lasemi et al.
Multiple sclerosis is a chronic immune-mediated disorder of the central nervous system characterized by demyelination, axonal injury, and neurodegeneration. Natural killer cells participate in MS through context-dependent regulatory and cyt...
Lamotrigine Ameliorates Epilepsy during Pregnancy in Rats by Inhibiting Astrocyte Activation via the NLRP3/TXNIP Pathway [0.03%]
拉莫三嗪通过抑制NLRP3/TXNIP途径激活的星形胶质细胞改善大鼠孕期癫痫发作
CuiYu You,YaLin Dong,Di Zhang et al.
CuiYu You et al.
This study was designed to investigate the impact of Lamotrigine (LTG) on astrocyte activation in epilepsy during pregnancy and to elucidate its potential underlying mechanisms. A rat model of epilepsy during pregnancy was established using...
Neuroimmunomodulation of AMPA Receptors Through Combination of Medium-Chain Triglycerides and Perampanel to Treat Status Epilepticus in Anti-NMDA Receptor Encephalitis [0.03%]
中链甘油三酯联合吡仑帕奈通过神经免疫调节AMPA受体治疗抗N-甲基-D天冬氨酸受体脑炎重症癫痫持续状态研究
Laura Marie Stadler,Laurin Schappe,Piergiorgio Lochner et al.
Laura Marie Stadler et al.
Recent studies have shown that a ketogenic diet containing medium-chain triglycerides (MCTs) has a synergistic effect with perampanel in modulating AMPA receptors. Both MCTs and perampanel have immunomodulatory properties. However, the use ...