Posttranscriptional Regulation of Cyclooxygenase 2 Expression in Colorectal Cancer [0.03%]
结直肠癌中环氧合酶2的转录后调控机制研究
Lisa E Young,Dan A Dixon
Lisa E Young
Cyclooxygenase (COX)-2 enzyme catalyzes the rate-limiting step of prostaglandin formation in pathogenic states, and overexpression of COX-2 occurs at multiple stages of colon carcinogenesis, allowing elevated prostaglandin synthesis to occu...
Shrikant Anant,Courtney W Houchen,Vaibhav Pawar et al.
Shrikant Anant et al.
RNA-binding proteins (RBPs) play key roles in the posttranscriptional regulation of gene expression. RBPs control various posttranscriptional events, including splicing, polyadenylation, mRNA stability, transport, and translation. It is bec...
Mandayam O Nandan,Vincent W Yang
Mandayam O Nandan
Colorectal cancer (CRC) is a significant health concern because of its associated mortality. Most CRCs exhibit dysregulation of the Wnt signaling pathway, caused by mutational inactivation of the adenomatous polyposis coli tumor suppressor ...
Secondary Prevention of Colorectal Cancer: Is There an Optimal Follow-up for Patients with Colorectal Cancer? [0.03%]
结直肠癌的二级预防：结直肠癌患者的随访是否有最佳方案？
John M Carethers
John M Carethers
Secondary prevention of colorectal cancer, as opposed to primary prevention, indicates that a person has already had the disease and there are steps being taken to prevent cancer recurrence, usually as metachronous tumors. This generally in...
Targeting Chemoprevention of Colorectal Cancer to Those Who Are Likely to Respond [0.03%]
针对可能受益人群进行结直肠癌化学预防
Reinhold W Stockbrugger
Reinhold W Stockbrugger
In the past four decades, chemoprevention of colorectal cancer (CRC) has been the subject of many epidemiologic and intervention trials of naturally occurring or pharmacologic agents. Recently, the positioning of cyclooxygenase 2 inhibitors...
Arun Thenappan,Ying Li,Kirti Shetty et al.
Arun Thenappan et al.
The recent identification of tumor-initiating colorectal cancer (CRC) stem cells in the pathogenesis of CRC has provided a potential target for novel therapeutics. Many details about CRC stem cells, however, remain poorly understood. Severa...
Beth B McConnell,Vincent W Yang
Beth B McConnell
Chronic inflammatory disorders are often associated with an increased risk of developing cancer. A classic example of the connection between inflammation and cancer is the increased risk of colorectal cancer in patients with inflammatory bo...
Irfan M Hisamuddin,Vincent W Yang
Irfan M Hisamuddin
Colorectal cancer (CRC) is a major cause of morbidity and mortality from cancers in the United States. Recent studies have revealed the paradigm in which sequential genetic changes (mutations) result in the progression from normal colonic t...
W Brian Dalton,Vincent W Yang
W Brian Dalton
Mitosis is a crucial part of the cell cycle. A successful mitosis requires the proper execution of many complex cellular behaviors. Thus, there are many points at which mitosis may be disrupted. In cancer cells, chronic disruption of mitosi...
Amr M Ghaleb,Vincent W Yang
Amr M Ghaleb
The Krüppel-like factor (KLF) proteins are zinc finger-containing transcription factors that exert important functions in regulating diverse biologic processes such as growth, proliferation, differentiation, development, inflammation, and ...