Toxicity Management in the Era of Changing Treatment Paradigms for Locally Advanced Rectal Cancer [0.03%]
局部晚期直肠癌治疗新模式时代的毒性管理
Anjalika R Kumar,Nina N Sanford
Anjalika R Kumar
Purpose of review: Treatment paradigms for locally advanced rectal cancer have evolved over the last several decades. Patients now have several different "standard" options with different radiation courses, sequencing of ...
Ishfaq Ahmed,Shahid Umar
Ishfaq Ahmed
Purpose of review: The trillions of microbes collectively referred to as the human microbiota, inhabit the human body and establish a beneficial relationship with the host. It is clear however that dysbiosis impacting mic...
Treating Colorectal Cancer with Immunotherapy: Implications for Single versus Combination Therapy [0.03%]
免疫疗法治疗结直肠癌：单药和联合用药的启示
Sophiya Karki,Shahid Umar,Anup Kasi
Sophiya Karki
Purpose of review: Colorectal cancer (CRC) is the second leading cause of cancer-associated deaths in the United States, with most metastatic cases subsequently turning refractory to standard chemotherapy. One of the prom...
Anup Kasi,Shivani Handa,Sajjad Bhatti et al.
Anup Kasi et al.
Purpose of review: Molecular pathways in colorectal carcinogenesis involve several complex genetic and epigenetic modulations that cause normal colonic mucosa to metamorphose into a benign polyp and subsequently into a ma...
Shane S Neibart,Sharon L Manne,Salma K Jabbour
Shane S Neibart
Purpose of review: With advances in radiation therapy (RT) techniques for rectal and anal cancers allowing for the modulation of critical normal tissues, there has been an increased emphasis on improving the quality of li...
Immunotherapy in Colorectal Cancer: Potential of Fecal Transplant and Microbiota-augmented Clinical Trials [0.03%]
免疫疗法在结直肠癌中的应用：粪便移植和微生物群增强的临床试验的潜力
Robin Park,Shahid Umar,Anup Kasi
Robin Park
Purpose of review: This review summarizes the role of the microbiome in colorectal cancer (CRC) in the setting of immunotherapy and emphasizes the potential of microbiota-influencing strategies with a focus on the use of ...
Systemic Therapy in BRAF V600E-Mutant Metastatic Colorectal Cancer: Recent Advances and Future Strategies [0.03%]
BRAF V600E突变转移性结直肠癌的系统治疗：近期进展和未来策略
Van K Morris
Van K Morris
Purpose of review: This review seeks to detail the clinical and pathologic features specific to BRAF V600E colorectal cancer. Application of novel preclinical findings translated into the clinic for the development of new...
Sooyeon Kim,Simon C Lee,Celette S Skinner et al.
Sooyeon Kim et al.
Purpose of review: Review strategies to improve outcomes of colorectal cancer treatment in older patients. Recent findings: Older color...
The Duplex Interaction of Microbiome with Chemoradiation and Immunotherapy: Potential Implications for Colorectal Cancer [0.03%]
肿瘤微环境中的肠道菌群与放化疗和免疫治疗的相互作用及对结直肠癌的影响展望
Azhar Saeed,Fariha Faruk Eshrat,Shahid Umar et al.
Azhar Saeed et al.
Purpose of review: Gut microbiota has the ability to modify the metabolism of wide array of therapeutic drugs. Current treatment modalities used in colorectal cancer have a narrow therapeutic index with a side effects pro...
Rachel E Brown,Sarah P Short,Christopher S Williams
Rachel E Brown
Purpose of review: Metabolic reprogramming is essential for the rapid proliferation of cancer cells and is thus recognized as a hallmark of cancer. In this review, we will discuss the etiologies and effects of metabolic r...