The Importance of the Pathologist's Role in Assessment of the Quality of the Mesorectum [0.03%]
病理医师对评价中间系膜切除标本质量作用的重要性
Steven L Bosch,Iris D Nagtegaal
Steven L Bosch
Total mesorectal excision (TME) is considered standard of care for rectal cancer treatment. Failure to remove the mesorectal fat envelope entirely may explain part of observed local and distant recurrences. Several studies suggest quality o...
What is the Best Way to Produce Consensus and Buy in to Guidelines for Rectal Cancer? [0.03%]
如何制定 rectal 癌症共识和指南的最佳方法？
Rebecca K S Wong,James Brierley,Melissa Brouwers
Rebecca K S Wong
Evidence-based guidelines are important tools and common pathways for translating evidence into clinical practice. It is most urgently needed when significant heterogeneity in practice exist. Actively engaging opinion leaders in the process...
Michael Schnekenburger,Marc Diederich
Michael Schnekenburger
In recent years, colorectal cancer (CRC) incidence has been increasing to become a major cause of morbidity and mortality worldwide from cancers, with high rates in westernized societies and increasing rates in developing countries. Epigene...
Xiazhen Yu,Yingjie Lin,Xie Yan et al.
Xiazhen Yu et al.
CD133, a member of the prominin family, is found in a variety of tissues with at least three variants. The function of CD133 is not well understood, but its expression is subject to changes in the microenvironment cues including bioenergeti...
Avedis Kazanjian,Noah F Shroyer
Avedis Kazanjian
The Notch receptor signaling pathway regulates expression of the basic helix-loop-helix transcription factor ATOH1 (Math1/Hath1) to determine cell fate in the intestine. In differentiating intestinal stem cells, high levels of Notch activit...
Mandayam O Nandan,Vincent W Yang
Mandayam O Nandan
Deaths caused by colorectal cancer (CRC) are among the leading causes of cancer-related death in the United States and around the world. Approximately 150,000 Americans are diagnosed with CRC each year and around 50,000 will die from it. Mu...
Molecular Prognostic and Predictive Markers in Colorectal Cancer: Current Status [0.03%]
结直肠癌的分子预后和预测标志物的现状
Jeffrey K Lee,Andrew T Chan
Jeffrey K Lee
In parallel with our growing understanding of the molecular pathways underlying colorectal neoplasia, significant advances have been made in the treatment of colorectal cancer (CRC). For the past few decades, 5-fluorouracil-based therapy ha...
Brian J Wilson,Tobias Schatton,Markus H Frank et al.
Brian J Wilson et al.
The hypothesis that cancer is driven by a subpopulation of tumor-initiating or cancer stem cells (CSC), defined by their selective ability for extensive self-renewal and capacity to give rise to nontumorigenic cancer cell progeny through di...
Graeme P Young,Linda J W Bosch
Graeme P Young
Detection of molecular markers for colorectal neoplasia in feces has the potential to improve performance of simple noninvasive screening tests for colorectal cancer. Most research has explored the value of DNA-based, RNA-based, and protein...
Joshua E Allen,Wafik S El-Deiry
Joshua E Allen
The significance of circulating tumor cells (CTCs) has been discussed for more than a century. The advent of modern technology has allowed for more reliable detection of CTCs, and recent studies have provided compelling evidence that CTCs p...