Prevention and Treatment of Colorectal Cancer by Natural Agents From Mother Nature [0.03%]
来自大自然的天然物质在 colorectal 癌症预防和治疗中的作用
Bharat Aggarwal,Sahdeo Prasad,Bokyung Sung et al.
Bharat Aggarwal et al.
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the United States after cancers of the lung and the breast/prostate. While the incidence of CRC in the United States is among the highest in the world (approximately 52/...
The Vitamin D Receptor, Inflammatory Bowel Diseases, and Colon Cancer [0.03%]
维生素D受体、炎症性肠病和结直肠癌之间的联系
Rong Lu,Shaoping Wu,Yinglin Xia et al.
Rong Lu et al.
The nuclear receptor is an emerging therapeutic target in various human diseases. Vitamin D receptor (VDR), a nuclear receptor, mediates the biological functions of vitamin D. Classically, vitamin D is recognized as an essential contributor...
Non-size-based response criteria to preoperative chemotherapy in patients with colorectal liver metastases: the morphologic response criteria [0.03%]
结直肠肝转移患者术前新辅助化疗的非基于大小疗效评价标准：影像学缓解标准
Junichi Shindoh,Yun Shin Chun,Evelyne M Loyer et al.
Junichi Shindoh et al.
Since the introduction of biologic agents, increasing data have suggested that conventional size-based RECIST criteria are not accurate in the assessment of response to therapy and non-size-based changes in tumor morphology can be a surroga...
Heather N Tinsley,Gary A Piazza
Heather N Tinsley
The chemopreventive efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) for colorectal cancer has been well documented. However, long-term use of NSAIDs is precluded owing to potentially fatal toxicities associated with their mechanis...
Mechanisms Regulating Microtubule Binding, DNA Replication, and Apoptosis are Controlled by the Intestinal Tumor Suppressor APC [0.03%]
调控微管结合、DNA复制和细胞凋亡的机制受肠肿瘤抑制基因APC控制
Erin M Perchiniak,Joanna Groden
Erin M Perchiniak
Colorectal cancer (CRC) results from the progressive accumulation of both genetic and epigenetic alterations that lead to the transformation of normal colorectal epithelium to benign (adenoma) and invasive (carcinoma) disease. Since its dis...
Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention [0.03%]
脂氧合酶和环氧化酶通路与结直肠癌的预防
Chinthalapally V Rao,Naveena B Janakiram,Altaf Mohammed
Chinthalapally V Rao
Colorectal cancer is one of the commonest malignancies in both men and women. In spite of significant progress in screening and in surgical and therapeutic interventions, colorectal cancer (CRC) is still a major public health problem. Accum...
Progastrin Peptides Increase the Risk of Developing Colonic Tumors: Impact on Colonic Stem Cells [0.03%]
蛋白胃泌素多肽增加发生结肠肿瘤的风险：对结肠干细胞的影响
Pomila Singh,Shubhashish Sarkar,Carla Kantara et al.
Pomila Singh et al.
Pre-neoplastic lesions (ACF, aberrant-crypt-foci; Hp, hyperplastic/dysplastic polyps) are believed to be precursors of sporadic colorectal-tumors (Ad, adenomas; AdCA, adenocarcinomas). ACF/Hp likely originate due to abnormal growth of colon...
Saima Sharif,Michael J O&#x;Connell
Saima Sharif
Understanding the biology of cancer is the key to understanding its behavior. Stage II colon cancers represent a unique treatment challenge for medical oncologists because they contain a very heterogeneous group of tumors with a wide range ...
Doron Boltin,Yaron Niv
Doron Boltin
Flexible sigmoidoscopy is a valid screening tool for the early detection of colorectal cancer (CRC). Recently published long-term data from UKFSST, a randomized controlled trial, demonstrate a 33% reduction in colorectal cancer incidence an...
Does Radiofrequency Ablation Add to Chemotherapy for Unresectable Liver Metastases? [0.03%]
射频消融能使化疗治疗无法切除的肝转移病灶更加有效吗？
Klaas M Govaert,Charlotte S van Kessel,Martijn Lolkema et al.
Klaas M Govaert et al.
In patients with unresectable colorectal liver metastases (CRLM), radiofrequency ablation (RFA) might be a good alternative, whenever possible. In contrast to systemic therapy, the aim of RFA is to achieve complete local tumor control in an...